Version: 8.0.0
Date: Tue Jan 28 2025
520 results for perp

Perp

(Rattus norvegicus)
Gene
Name: p53 apoptosis effector related to PMP22
Synonyms: p53 apoptosis effector related to PMP-22, PERP, TP53 apoptosis effector, LOC292949
Source: RGD:1310294
Biotype: protein coding gene
Symbol: Perp (Rno)
Symbol: Perp
Gene Synopsis: Orthologous to human PERP (p53 apoptosis effector related to PMP22); PARTICIPATES IN p53 signaling pathway
Automated Gene Synopsis: Orthologous to human PERP (p53 apoptosis effector related to PMP22).
Strict Orthology Symbols: perp

Perp

(Mus musculus)
Gene
Name: PERP, TP53 apoptosis effector
Synonyms: KRTCAP1, RIKEN cDNA 1110017A08 gene, PIGPC1, KCP1, 1110017A08Rik
Source: MGI:1929938
Biotype: protein coding gene
Symbol: Perp (Mmu)
Symbol: Perp
Automated Gene Synopsis: Orthologous to human PERP (p53 apoptosis effector related to PMP22).
Strict Orthology Symbols: perp
Alleles: Perp (Mmu)...Perp (Mmu)...Perp (Mmu)...Perp (Mmu)...Perp (Mmu)

perp

(Danio rerio)
Gene
Name: p53 apoptosis effector related to pmp22
Synonyms: fk24g11, wu:fk24g11
Source: ZFIN:ZDB-GENE-050104-1
Biotype: protein coding gene
Symbol: perp (Dre)
Symbol: perp
Automated Gene Synopsis: Orthologous to human PERP (p53 apoptosis effector related to PMP22).
Strict Orthology Symbols: perp

PERP

(Homo sapiens)
Gene
Name: p53 apoptosis effector related to PMP22
Synonyms: RP3-496H19.1, p53-induced protein PIGPC1, THW, dJ496H19.1, keratinocyte-associated protein 1, 1110017A08Rik, transmembrane protein THW, OLMS2, KRTCAP1, keratinocytes associated protein 1, keratinocyte associated protein 1, p53 apoptosis effector related to PMP-22, EKVP7, PIGPC1, KCP1, PERP, TP53 apoptosis effector, KCP-1
Source: HGNC:17637
Biotype: protein coding gene
Symbol: PERP (Hsa)
Symbol: PERP
Strict Orthology Symbols: perp

perp

(Xenopus tropicalis)
Gene
Name: PERP, TP53 apoptosis effector
Synonyms: thw, pigpc1, perp, krtcap1, kcp1, PERP, TP53 apoptosis effector
Source: Xenbase:XB-GENE-876436
Biotype: gene
Symbol: perp
Symbol: perp (Xtr)
Automated Gene Synopsis: Orthologous to human PERP (p53 apoptosis effector related to PMP22).
Synonyms: perp...perp...perp
Strict Orthology Symbols: perp

perp.S

(Xenopus laevis)
Gene
Name: PERP, TP53 apoptosis effector
Synonyms: thw, pigpc1, krtcap1, kcp1, perp.S, PERP, TP53 apoptosis effector
Source: Xenbase:XB-GENE-6254601
Biotype: gene
Symbol: perp.S (Xla)
Automated Gene Synopsis: Orthologous to human PERP (p53 apoptosis effector related to PMP22).
Strict Orthology Symbols: perp
Symbol: perp.S

Perptm1Att

(Mus musculus)
Allele/Variant
Source: MGI:2683069
Genes: Perp (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Perp (Mmu)
Genes: Perp (Mmu)
Symbol: Perptm1Att

Perpem1Smoc

(Mus musculus)
Allele/Variant
Source: MGI:7291616
Genes: Perp (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Perp (Mmu)
Genes: Perp (Mmu)
Symbol: Perpem1Smoc

Perpem1Gpt

(Mus musculus)
Allele/Variant
Source: MGI:7304102
Genes: Perp (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Perp (Mmu)
Genes: Perp (Mmu)
Symbol: Perpem1Gpt

Perpem2Gpt

(Mus musculus)
Allele/Variant
Source: MGI:7304103
Genes: Perp (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Perp (Mmu)
Genes: Perp (Mmu)
Symbol: Perpem2Gpt

Perptm2Att

(Mus musculus)
Allele/Variant
Source: MGI:4882063
Genes: Perp (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Perp (Mmu)
Genes: Perp (Mmu)
Symbol: Perptm2Att

PERPP1

(Homo sapiens)
Gene
Name: PERP pseudogene 1
Synonyms: Not Available
Source: HGNC:56619
Biotype: pseudogene
Symbol: PERPP1 (Hsa)
Symbol: PERPP1

PERPP3

(Homo sapiens)
Gene
Name: PERP pseudogene 3
Synonyms: PERP, TP53 apoptosis effector pseudogene, LOC100131159
Source: HGNC:56913
Biotype: pseudogene
Symbol: PERPP3 (Hsa)
Symbol: PERPP3

PERPP2

(Homo sapiens)
Gene
Name: PERP pseudogene 2
Synonyms: LOC124903553, p53 apoptosis effector related to PMP-22-like
Source: HGNC:56620
Biotype: pseudogene
Symbol: PERPP2 (Hsa)
Symbol: PERPP2

Perptm2Att/Perptm2Att Tg(KRT14-cre/ERT2)1Ipc/0 [background:] involves: 129S4/SvJae

(Mus musculus)
Model
Id: MGI:4882073
Synonyms: Not Available
Symbol: Perp/Perp Tg(KRT14-cre/ERT2)1Ipc/0 [background:] involves: 129S4/SvJae (Mmu)
Genes: Perp (Mmu)
Alleles: Perp (Mmu)
Name: Perp/Perp Tg(KRT14-cre/ERT2)1Ipc/0 [background:] involves: 129S4/SvJae

Perptm1Att/Perptm1Att [background:] involves: 129S4/SvJae

(Mus musculus)
Model
Id: MGI:2683072
Synonyms: Not Available
Symbol: Perp/Perp [background:] involves: 129S4/SvJae (Mmu)
Genes: Perp (Mmu)
Alleles: Perp (Mmu)
Name: Perp/Perp [background:] involves: 129S4/SvJae

vab-9

(Caenorhabditis elegans)
Gene
Name: Variable ABnormal morphology 9
Synonyms: CELE_T22C8.8, T22C8.8
Source: WB:WBGene00006875
Biotype: protein coding gene
Strict Orthology Symbols: perp

CG45049

(Drosophila melanogaster)
Gene
Name: Not Available
Synonyms: CG17618, CG6982
Source: FB:FBgn0266409
Biotype: protein coding gene
Strict Orthology Symbols: perp

mutilating palmoplantar keratoderma with periorificial keratotic plaques

Disease
Source: DOID:0112011
Definition: A keratosis characterized by a bilateral mutilating palmoplantar keratoderma and periorificial keratotic plaques with severe pruritus of lesions.
Genes: perp.S (Xla)...perp (Xtr)...PERP (Hsa)...Perp (Rno)...Perp (Mmu)

erythrokeratodermia variabilis

Disease
Source: DOID:0050467
Definition: A skin disease that is characterized by areas of sharply demarcated, brown hyperkeratosis and has_material_basis_in mutations in genes encoding for connexin channels proteins in the epidermis.
Genes: Perp (Mmu)...perp (Xtr)...perp (Dre)...PERP (Hsa)...Perp (Rno)

response to perphenazine

Gene Ontology
Source: GO:0097334
Synonyms: Not Available
Branch: biological process
Symbol: response to perphenazine

desmosome organization

Gene Ontology
Source: GO:0002934
Synonyms: Not Available
Branch: biological process
Genes: Perp (Mmu)...PERP (Hsa)...Perp (Rno)

mammary gland duct morphogenesis

Gene Ontology
Source: GO:0060603
Synonyms: Not Available
Branch: biological process
Genes: Perp (Mmu)...PERP (Hsa)...Perp (Rno)

positive regulation of T cell apoptotic process

Gene Ontology
Source: GO:0070234
Synonyms:
  • activation of T cell apoptosis
  • positive regulation of T cell apoptosis
Branch: biological process
Genes: Perp (Mmu)...PERP (Hsa)...Perp (Rno)

ubs1Tg + MO3-perp

(Danio rerio)
Model
Id: ZFIN:ZDB-FISH-170525-39
Synonyms: Not Available
Genes: perp (Dre)
Name: ubs1Tg + MO3-perp

ubs1Tg + MO1-tnnt2a + MO3-perp

(Danio rerio)
Model
Id: ZFIN:ZDB-FISH-170525-40
Synonyms: Not Available
Genes: perp (Dre)
Name: ubs1Tg + MO1-tnnt2a + MO3-perp

ubs1Tg + MO1-tnnt2a + MO2-perp

(Danio rerio)
Model
Id: ZFIN:ZDB-FISH-170525-27
Synonyms: Not Available
Genes: perp (Dre)
Name: ubs1Tg + MO1-tnnt2a + MO2-perp

ubs1Tg + MO1-pdcd2l + MO1-tnnt2a + MO2-perp

(Danio rerio)
Model
Id: ZFIN:ZDB-FISH-170525-42
Synonyms: Not Available
Genes: perp (Dre)
Name: ubs1Tg + MO1-pdcd2l + MO1-tnnt2a + MO2-perp

la012273Tg

(Danio rerio)
Allele/Variant
Source: ZFIN:ZDB-ALT-120806-9690
Genes: perp (Dre)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Genes: perp (Dre)

ubs1Tg + MO2-perp

(Danio rerio)
Model
Id: ZFIN:ZDB-FISH-170525-20
Synonyms: Not Available
Genes: perp (Dre)
Name: ubs1Tg + MO2-perp

WT + MO1-perp

(Danio rerio)
Model
Id: ZFIN:ZDB-FISH-150901-8240
Synonyms: Not Available
Genes: perp (Dre)
Name: WT + MO1-perp

activation of cysteine-type endopeptidase activity

Gene Ontology
Source: GO:0097202
Synonyms:
  • activation of caspase activity
  • activation of metacaspase activity
Branch: biological process
Genes: Perp (Mmu)...Perp (Rno)...PERP (Hsa)

ubs1Tg + MO1-tnnt2a + MO2-perp + MO4-tp53

(Danio rerio)
Model
Id: ZFIN:ZDB-FISH-170525-44
Synonyms: Not Available
Genes: perp (Dre)
Name: ubs1Tg + MO1-tnnt2a + MO2-perp + MO4-tp53

amelogenesis

Gene Ontology
Source: GO:0097186
Synonyms:
  • enamel development
Branch: biological process
Genes: Perp (Mmu)...PERP (Hsa)...Perp (Rno)

Transcriptional profiling of wild-type vs Perp-null mice during tooth development

(Mus musculus)
HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:E-GEOD-26796, GEO:GSE26796
Tags: WT vs. mutant, genotype
Summary: Little is known about the role of cell-cell adhesion in the development of mineralized tissues. Here we report that PERP, a tetraspan membrane protein essential for epithelial integrity, is a critical regulator of enamel formation. Perp is necessary for proper cell attachment and gene expression during tooth development, and its expression is controlled by P63, a master regulator of stratified epithelial development. During enamel formation, PERP is localized to the interface between the enamel-producing ameloblasts and the stratum intermedium (SI), a layer of cells subjacent to the ameloblasts. Perp-null mice display dramatic enamel defects, which are caused, in part, by the detachment of ameloblasts from the SI. Microarray analysis comparing gene expression in teeth of wild-type and Perp-null mice identified several differentially expressed genes during enamel formation. Analysis of these genes in ameloblast-derived LS8 cells upon knock down of PERP confirmed the role for PERP in the regulation of gene expression. Together, our data show that PERP is necessary for the integrity of the ameloblast-SI interface and that the lack of Perp causes downregulation of genes that are critical for proper enamel formation. Two-condition experiment, RNA isolated from WT vs. Perp-null lower 1st molars. Biological replicates: 3 control replicates, 3 mutant replicates.
Symbol: Transcriptional profiling of wild-type vs Perp-null mice during tooth development

heterotypic cell-cell adhesion

Gene Ontology
Source: GO:0034113
Synonyms: Not Available
Branch: biological process
Genes: Perp (Mmu)...Perp (Rno)...PERP (Hsa)

positive regulation of proteolysis

Gene Ontology
Source: GO:0045862
Synonyms:
  • activation of proteolysis
  • positive regulation of peptidolysis
Branch: biological process
Genes: Perp (Mmu)...Perp (Rno)...PERP (Hsa)

positive regulation of neutrophil chemotaxis

Gene Ontology
Source: GO:0090023
Synonyms: Not Available
Branch: biological process
Genes: Perp (Mmu)...Perp (Rno)...PERP (Hsa)

desmosome

Gene Ontology
Source: GO:0030057
Synonyms:
  • macula adherens
  • spot desmosome
Branch: cellular component
Genes: Perp (Mmu)...Perp (Rno)...perp (Dre)...PERP (Hsa)

intrinsic apoptotic signaling pathway by p53 class mediator

Gene Ontology
Source: GO:0072332
Synonyms:
  • intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator
  • signal transduction by p53 class mediator resulting in induction of apoptosis
Branch: biological process
Genes: Perp (Mmu)...Perp (Rno)...PERP (Hsa)

apoptotic process involved in blood vessel morphogenesis

Gene Ontology
Source: GO:1902262
Synonyms:
  • apoptosis involved in patterning of blood vessels
  • apoptotic cell death involved in patterning of blood vessels
Branch: biological process
Genes: perp (Dre)

tissue homeostasis

Gene Ontology
Source: GO:0001894
Synonyms:
  • tissue maintenance
Branch: biological process
Genes: Perp (Mmu)...Perp (Rno)...PERP (Hsa)

response to UV

Gene Ontology
Source: GO:0009411
Synonyms:
  • response to UV light stimulus
  • response to UV radiation stimulus
Branch: biological process
Genes: perp (Dre)

cell-cell adhesion

Gene Ontology
Source: GO:0098609
Synonyms:
  • single organismal cell-cell adhesion
Branch: biological process
Genes: Perp (Rno)...Perp (Mmu)...PERP (Hsa)...perp (Dre)

cell-cell junction

Gene Ontology
Source: GO:0005911
Synonyms:
  • cell-cell contact region
  • cell-cell contact zone
Branch: cellular component
Genes: Perp (Rno)...Perp (Mmu)...PERP (Hsa)...perp (Dre)

Notch signaling pathway

Gene Ontology
Source: GO:0007219
Synonyms:
  • N signaling pathway
  • N signalling pathway
Branch: biological process
Genes: Perp (Rno)...Perp (Mmu)...PERP (Hsa)

anchoring junction

Gene Ontology
Source: GO:0070161
Synonyms:
  • anchoring cell junction
Branch: cellular component
Genes: perp (Dre)...PERP (Hsa)

regulation of apoptotic process

Gene Ontology
Source: GO:0042981
Synonyms:
  • apoptosis regulator activity
  • regulation of apoptosis
Branch: biological process
Genes: perp (Dre)

cell adhesion

Gene Ontology
Source: GO:0007155
Synonyms:
  • cell adhesion molecule activity
  • single organism cell adhesion
Branch: biological process
Genes: PERP (Hsa)...perp (Dre)

(GRCh38)6:138092233C>T

(Homo sapiens)
Allele/Variant
Source: rs759496728
Genes: PERP (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: (GRCh38)6:138092233C>T