Version: 8.0.0Date: Tue Jan 28 2025
Category
RtcB
(Drosophila melanogaster)Gene
Name: RtcB RNA ligase
Synonyms: CG9987, Rtcb, RtcB-like
Source: FB:FBgn0032781
Biotype: protein coding gene
Symbol: RtcB
Symbol: RtcB (Dme)
Automated Gene Synopsis: Orthologous to human RTCB (RNA 2',3'-cyclic phosphate and 5'-OH ligase).
Synonyms: Rtcb...Rtcb
Strict Orthology Symbols: rtcb
Alleles: RtcB
Rtcb
(Rattus norvegicus)Gene
Name: RNA 2',3'-cyclic phosphate and 5'-OH ligase
Synonyms: P55, hypothetical protein LOC362855, RNA-splicing ligase RtcB homolog, tRNA-splicing ligase RtcB homolog, 3'-phosphate/5'-hydroxy nucleic acid ligase, LOC362855
Source: RGD:1303261
Biotype: protein coding gene
Symbol: Rtcb (Rno)
Symbol: Rtcb
Gene Synopsis: Orthologous to human RTCB (RNA 2',3'-cyclic phosphate and 5'-OH ligase); PARTICIPATES IN tRNA maturation
Automated Gene Synopsis: Orthologous to human RTCB (RNA 2',3'-cyclic phosphate and 5'-OH ligase).
Synonyms: RNA-splicing ligase RtcB homolog...tRNA-splicing ligase RtcB homolog
Strict Orthology Symbols: rtcb
RTCB
(Homo sapiens)Gene
Name: RNA 2',3'-cyclic phosphate and 5'-OH ligase
Synonyms: HSPC117, hypothetical protein LOC51493, ankyrin repeat domain 54, RP1-149A16.6, focal adhesion-associated protein, RNA-splicing ligase RtcB homolog, DJ149A16.6, FAAP, novel protein HSPC117, C22orf28, tRNA-splicing ligase RtcB homolog, 3'-phosphate/5'-hydroxy nucleic acid ligase
Source: HGNC:26935
Biotype: protein coding gene
Symbol: RTCB (Hsa)
Symbol: RTCB
Synonyms: RNA-splicing ligase RtcB homolog...tRNA-splicing ligase RtcB homolog
Strict Orthology Symbols: rtcb
Rtcb
(Mus musculus)Gene
Name: RNA 2',3'-cyclic phosphate and 5'-OH ligase
Synonyms: D10Wsu52e, HSPC117, AI255213, DNA segment, Chr 10, Wayne State University 52, expressed, expressed sequence AI463255, AI463255, expressed sequence AI255213
Source: MGI:106379
Biotype: protein coding gene
Symbol: Rtcb (Mmu)
Symbol: Rtcb
Automated Gene Synopsis: Orthologous to human RTCB (RNA 2',3'-cyclic phosphate and 5'-OH ligase).
Strict Orthology Symbols: rtcb
Alleles: Rtcb
rtcb
(Danio rerio)Gene
Name: RNA 2',3'-cyclic phosphate and 5'-OH ligase
Synonyms: zgc:76871
Source: ZFIN:ZDB-GENE-040426-2096
Biotype: protein coding gene
Symbol: rtcb (Dre)
Symbol: rtcb
Automated Gene Synopsis: Orthologous to human RTCB (RNA 2',3'-cyclic phosphate and 5'-OH ligase).
Strict Orthology Symbols: rtcb
rtcb
(Xenopus tropicalis)Gene
Name: RNA 2',3'-cyclic phosphate and 5'-OH ligase
Synonyms: rtcb, RNA 2',3'-cyclic phosphate and 5'-OH ligase
Source: Xenbase:XB-GENE-974751
Biotype: gene
Symbol: rtcb
Symbol: rtcb (Xtr)
Gene Synopsis: Uncharacterized conserved protein, contains RtcB domain
Automated Gene Synopsis: Orthologous to human RTCB (RNA 2',3'-cyclic phosphate and 5'-OH ligase).
Synonyms: rtcb...rtcb...rtcb
Strict Orthology Symbols: rtcb
rtcb-1
(Caenorhabditis elegans)Gene
Name: RTCB (tRNA-splicing ligase) homolog 1
Synonyms: CELE_F16A11.2, F16A11.2
Source: WB:WBGene00008877
Biotype: protein coding gene
Symbol: rtcb-1 (Cel)
Automated Gene Synopsis: Orthologous to human RTCB (RNA 2',3'-cyclic phosphate and 5'-OH ligase).
Strict Orthology Symbols: rtcb
Symbol: rtcb-1
rtcb.L
(Xenopus laevis)Gene
Name: RNA 2',3'-cyclic phosphate and 5'-OH ligase
Synonyms: rtcb.L, RNA 2',3'-cyclic phosphate and 5'-OH ligase
Source: Xenbase:XB-GENE-974756
Biotype: gene
Symbol: rtcb.L (Xla)
Gene Synopsis: Uncharacterized conserved protein, contains RtcB domain
Automated Gene Synopsis: Orthologous to human RTCB (RNA 2',3'-cyclic phosphate and 5'-OH ligase).
Strict Orthology Symbols: rtcb
Symbol: rtcb.L
rtcb.S
(Xenopus laevis)Gene
Name: RNA 2',3'-cyclic phosphate and 5'-OH ligase
Synonyms: RNA 2',3'-cyclic phosphate and 5'-OH ligase, rtcb.S
Source: Xenbase:XB-GENE-17345355
Biotype: gene
Symbol: rtcb.S (Xla)
Gene Synopsis: Uncharacterized conserved protein, contains RtcB domain
Automated Gene Synopsis: Orthologous to human RTCB (RNA 2',3'-cyclic phosphate and 5'-OH ligase).
Strict Orthology Symbols: rtcb
Symbol: rtcb.S
RtcBU6.NIG.sgRNA
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0379285
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: RtcB
Construct Knockdown Component: RtcB (Dme)
Symbol: RtcBU6.NIG.sgRNA
RtcBGD14336
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0206440
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: RtcB
Construct Knockdown Component: RtcB (Dme)
Symbol: RtcBGD14336
Constructs: RtcB RNAi #1...RtcB RNAi #1
Rtcbtm1a(KOMP)Wtsi
(Mus musculus)Allele/Variant
Source: MGI:4362526
Genes: Rtcb (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Rtcb
Genes: Rtcb (Mmu)
Symbol: Rtcbtm1a(KOMP)Wtsi
RtcBGD14763
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0206441
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: RtcB
Construct Knockdown Component: RtcB (Dme)
Symbol: RtcBGD14763
Constructs: RtcB RNAi #2...RtcB RNAi #2
Rtcbtm1Hyfn
(Mus musculus)Allele/Variant
Source: MGI:7444023
Genes: Rtcb (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Rtcb
Genes: Rtcb (Mmu)
Symbol: Rtcbtm1Hyfn
Rtcbtm1c(KOMP)Wtsi
(Mus musculus)Allele/Variant
Source: MGI:5688394
Genes: Rtcb (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Rtcb
Genes: Rtcb (Mmu)
Symbol: Rtcbtm1c(KOMP)Wtsi
RtcBNIG.9987R
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0276632
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: RtcB
Construct Knockdown Component: RtcB (Dme)
Symbol: RtcBNIG.9987R
RtcB RNA ligase (Kosmaczewski 2014)
(Caenorhabditis elegans)HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by WB
ID: WB:RNASeq_Study.SRP047464,
Tags: response to unfolded protein
Summary: The RtcB RNA ligase is an essential component of the metazoan unfolded protein response.
Symbol: RtcB RNA ligase (Kosmaczewski 2014)
Name: RtcB RNA ligase (Kosmaczewski 2014)
Rtcb-ps1
(Rattus norvegicus)Gene
Name: RNA 2',3'-cyclic phosphate and 5'-OH ligase, pseudogene 1
Synonyms: AABR07057196.1, similar to CG9987-PA, LOC689014
Source: RGD:1597472
Biotype: pseudogene
Symbol: Rtcb-ps1 (Rno)
Symbol: Rtcb-ps1
Id: MGI:7620017
Synonyms: Not Available
Symbol: Rtcb/Rtcb Tg(Gdf9-icre)5092Coo/0 [background:] involves: C57BL/6J (Mmu)
Genes: Rtcb (Mmu)
Alleles: Rtcb
Name: Rtcb/Rtcb Tg(Gdf9-icre)5092Coo/0 [background:] involves: C57BL/6J
Rtcbtm1c(KOMP)Wtsi/Rtcbtm1c(KOMP)Wtsi Tg(Fcer2a-cre)5Mbu/0 [background:] involves: C57BL/6 * CBA * SJL
(Mus musculus)Model
Id: MGI:5688397
Synonyms: Not Available
Symbol: Rtcb/Rtcb Tg(Fcer2a-cre)5Mbu/0 [background:] involves: C57BL/6 * CBA
Genes: Rtcb (Mmu)
Alleles: Rtcb
Name: Rtcb/Rtcb Tg(Fcer2a-cre)5Mbu/0 [background:] involves: C57BL/6 * CBA
RtcBf05494
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0160742
Genes: RtcB (Dme)
Synonyms: Not Available
Variant Type: insertion
Molecular Consequence: 3_prime_UTR_variant
Diseases: Not Available
Variant Name: Not Available
Symbol: RtcB
Gene Synonyms: Rtcb
Genes: RtcB (Dme)
Symbol: RtcBf05494
Gene Ontology
Source: GO:0003972
Synonyms:
- poly(ribonucleotide):poly(ribonucleotide) ligase (AMP-forming)
- polyribonucleotide ligase activity
Branch: molecular function
Genes: rtcb (Dre)...rtcb-1 (Cel)...Rtcb (Mmu)
Gene Ontology
Source: GO:0072669
Synonyms:
- tRNA splicing ligase complex
Branch: cellular component
Genes: RTCB (Hsa)...Rtcb (Rno)...RtcB (Dme)...rtcb (Dre)...Rtcb (Mmu)
Gene Ontology
Source: GO:0016886
Synonyms: Not Available
Branch: molecular function
Genes: rtcb-1 (Cel)...RTCB (Hsa)
Gene Ontology
Source: GO:0170057
Synonyms:
- 3'-phosphate/5'-hydroxy nucleic acid ligase activity
Branch: molecular function
Genes: RtcB (Dme)...rtcb (Dre)...RTCB (Hsa)...Rtcb (Rno)...Rtcb (Mmu)
VC1094
(Caenorhabditis elegans)Model
Id: WB:WBStrain00036319
Synonyms: Not Available
Genes: rtcb-1 (Cel)
Gene Ontology
Source: GO:0008452
Synonyms: Not Available
Branch: molecular function
Genes: rtcb (Dre)...rtcb-1 (Cel)
Gene Ontology
Source: GO:0017166
Synonyms: Not Available
Branch: molecular function
Genes: RTCB (Hsa)...Rtcb (Rno)...Rtcb (Mmu)
Gene Ontology
Source: GO:2000237
Synonyms:
- positive regulation of tRNA maturation
Branch: biological process
Genes: RtcB (Dme)
Source: GO:0006388
Synonyms:
- tRNA-Y splicing
Branch: biological process
Genes: RTCB (Hsa)...rtcb (Dre)...Rtcb (Mmu)...Rtcb (Rno)...RtcB (Dme)
sa33351
(Danio rerio)Allele/Variant
Source: ZFIN:ZDB-ALT-190123-92
Genes: rtcb (Dre)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Genes: rtcb (Dre)
RNA Ligase RTCB-mediated mRNA Alternative Splicing is Required for Mouse Oocyte Development and Maintenance
(Mus musculus)HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:GSE190681
Tags: WT vs. mutant, genotype
Summary: Intron splicing of the pre-mRNA is usually coupled with the transcription elongation catalyzed by RNA polymerase. However, recent large-scale mRNA sequencing showed that introns are still retained in 5-10% of mRNA, these introns are named as exitrons. They are deleted in some special cells or conditions to deal with developmental transition or cellular stress response. The role of this mechanism in mammalian female reproduction is elusive so far. We found that RNA terminal phosphate cyclase B (RTCB) mainly regulated splicing of these transcripts related to p-CDK1, DNA methylation and DNA damage repair. On the one hand, it regulated the recovery of oocyte meiosis by affecting CDK1 activation. On the other hand, it also regulated the developmental potential of oocytes by influencing splicing of DNA methylation and DNA damage repair-related mRNA. In addition, it could also play a crucial role in follicular development. Rtcb deletion resulted in the accumulation of these maternal mRNAs containing unspliced introns, and the decline of the overall level of transcripts. As a result, Rtcb-/- female are sterile. Our study highlights the important role of RTCB-regulated non-canonical alternative splicing in female reproduction. A total of 6 samples were analyzed in this study, including WT and Rtcb knock-out oocytes from fully-grown GV stage. Each biological samples has three replicates.
Symbol: RNA Ligase RTCB-mediated mRNA Alternative Splicing is Required for Mouse Oocyte Development and Maintenance
Gene Ontology
Source: GO:0001890
Synonyms:
- placental development
- placentation
Branch: biological process
Genes: Rtcb (Mmu)...RTCB (Hsa)...Rtcb (Rno)
Gene Ontology
Source: GO:0040025
Synonyms: Not Available
Branch: biological process
Genes: rtcb-1 (Cel)
Gene Ontology
Source: GO:0008033
Synonyms:
- tRNA maturation
Branch: biological process
Genes: RTCB (Hsa)...rtcb (Dre)...RtcB (Dme)...rtcb-1 (Cel)
Gene Ontology
Source: GO:0016874
Synonyms:
- synthetase activity
Branch: molecular function
Genes: RTCB (Hsa)...rtcb (Dre)...Rtcb-ps1 (Rno)...rtcb-1 (Cel)
Gene Ontology
Source: GO:0036498
Synonyms:
- ERN1-mediated unfolded protein response
- IRE1 branch of UPR
Branch: biological process
Genes: rtcb-1 (Cel)
Gene Ontology
Source: GO:0005635
Synonyms: Not Available
Branch: cellular component
Genes: RTCB (Hsa)...Rtcb (Rno)...Rtcb (Mmu)...rtcb-1 (Cel)
Gene Ontology
Source: GO:0006396
Synonyms: Not Available
Branch: biological process
Genes: RTCB (Hsa)...rtcb (Dre)...Rtcb-ps1 (Rno)...rtcb-1 (Cel)
Disease
Source: DOID:14330
Definition: A synucleinopathy that has_material_basis_in degeneration of the central nervous system that often impairs motor skills, speech, and other functions.
Genes: RTCB (Hsa)...Rtcb (Rno)...rtcb (Dre)...Rtcb (Mmu)...rtcb (Xtr)
Gene Ontology
Source: GO:0001701
Synonyms: Not Available
Branch: biological process
Genes: RTCB (Hsa)...Rtcb (Rno)...Rtcb (Mmu)
Gene Ontology
Source: GO:0005525
Synonyms: Not Available
Branch: molecular function
Genes: RTCB (Hsa)...Rtcb (Rno)...rtcb-1 (Cel)...rtcb (Dre)...Rtcb (Mmu)
Gene Ontology
Source: GO:0007281
Synonyms:
- gametogenesis
- germ-cell development
Branch: biological process
Genes: rtcb-1 (Cel)
(GRCh38)22:32407123T>C
(Homo sapiens)Allele/Variant
Source: rs207477955
Genes: RTCB (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: non_coding_transcript_variant, intron_variant
Diseases: Not Available
Variant Name: (GRCh38)22:32407123T>C
Gene Synonyms: RNA-splicing ligase RtcB homolog...tRNA-splicing ligase RtcB homolog
(GRCh38)22:32398033T>C
(Homo sapiens)Allele/Variant
Source: rs776896020
Genes: RTCB (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)22:32398033T>C
Gene Synonyms: RNA-splicing ligase RtcB homolog...tRNA-splicing ligase RtcB homolog
(GRCh38)22:32398100A>G
(Homo sapiens)Allele/Variant
Source: rs750059803
Genes: RTCB (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: splice_region_variant, non_coding_transcript_exon_variant, synonymous_variant
Diseases: Not Available
Variant Name: (GRCh38)22:32398100A>G
Gene Synonyms: RNA-splicing ligase RtcB homolog...tRNA-splicing ligase RtcB homolog
(GRCh38)22:32393947A>G
(Homo sapiens)Allele/Variant
Source: rs765879347
Genes: RTCB (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: (GRCh38)22:32393947A>G
Gene Synonyms: RNA-splicing ligase RtcB homolog...tRNA-splicing ligase RtcB homolog
(GRCh38)22:32388040G>C
(Homo sapiens)Allele/Variant
Source: rs374100495
Genes: RTCB (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: (GRCh38)22:32388040G>C
Gene Synonyms: RNA-splicing ligase RtcB homolog...tRNA-splicing ligase RtcB homolog
(GRCh38)22:32401757T>C
(Homo sapiens)Allele/Variant
Source: rs200793446
Genes: RTCB (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)22:32401757T>C
Gene Synonyms: RNA-splicing ligase RtcB homolog...tRNA-splicing ligase RtcB homolog
(GRCh38)22:32395208C>T
(Homo sapiens)Allele/Variant
Source: rs202229511
Genes: RTCB (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: (GRCh38)22:32395208C>T
Gene Synonyms: RNA-splicing ligase RtcB homolog...tRNA-splicing ligase RtcB homolog