Version: 8.1.0Date: Fri Apr 18 2025
Category
Sas-6
(Drosophila melanogaster)Gene
Name: Spindle assembly abnormal 6
Synonyms: DSas-6, sas6, Dsas6, dsas-6, sas-6, DSas6, Sas-6, DSAS-6, Sas6, spindle assembly abnormal 6, SAS6, CG15524, SAS-6, Spindle assembly abnormal 6 ortholog
Source: FB:FBgn0039731
Biotype: protein coding gene
Symbol: Sas-6 (Dme)
Symbol: Sas-6
Synonyms: sas-6...Sas-6...SAS-6...sas-6...Sas-6...SAS-6...sas-6...sas-6...Sas-6...SAS-6
Alleles: Sas-6
sas-6
(Caenorhabditis elegans)Gene
Name: Spindle ASsembly abnormal 6
Synonyms: Y45F10D.9, CELE_Y45F10D.9
Source: WB:WBGene00012888
Biotype: protein coding gene
Symbol: sas-6 (Cel)
Symbol: sas-6
Gene Synopsis: sas-6 is a member of an evolutionarily conserved family of proteins containing a coiled-coil region and...conserved in similar proteins in at least eight other species that contain basal bodies or centrioles; SAS...activity, along with that of ZYG-1, SAS-4, SAS-5, and SPD-2, is essential for centriole duplication; SAS...-6 functions in a dose-dependent manner and localizes to centriolar cylinders; SAS-6 co-localizes to...-6 localization also requires the activity of the ZYG-1 kinase; in addition to the early embryo, SAS-
Cross References: WB:sas-6...sas-6...sas-6
Sas-6mNeonGreen.N
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0376241
Genes: Sas-6 (Dme)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Sas-6
Gene Synonyms: sas-6...Sas-6...SAS-6
Genes: Sas-6 (Dme)
Name: Sas-6mNeonGreen.N
Symbol: Sas-6mNeonGreen.N
Sas-6UASp.Tag:FLAG
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0367817
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Sas-6
Name: Sas-6UASp.Tag:FLAG
Construct Expressed Component: Sas-6 (Dme)
Symbol: Sas-6UASp.Tag:FLAG
Sas-6Ubi.GFP
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0212771
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Sas-6
Name: Sas-6Ubi.GFP
Construct Expressed Component: Sas-6 (Dme)
Symbol: Sas-6Ubi.GFP
Constructs: P{Ubi-GFP-sas-6}
Sas-6UAS.C.GFP
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0363479
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Sas-6
Name: Sas-6UAS.C.GFP
Construct Expressed Component: Sas-6 (Dme)
Symbol: Sas-6UAS.C.GFP
Sas-6Ubi.P.GFP
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0240462
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Sas-6
Name: Sas-6Ubi.P.GFP
Construct Expressed Component: Sas-6 (Dme)
Symbol: Sas-6Ubi.P.GFP
Constructs: Ubq-GFP-Sas-6...GFP-Sas-6
Sas-6Ubi.PC.GFP
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0388713
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Sas-6
Name: Sas-6Ubi.PC.GFP
Construct Expressed Component: Sas-6 (Dme)
Symbol: Sas-6Ubi.PC.GFP
Constructs: WT GFP-Sas-6
Sas-6mCherry
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0366905
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Sas-6
Name: Sas-6mCherry
Construct Expressed Component: Sas-6 (Dme)
Symbol: Sas-6mCherry
Constructs: P{mCherry-Sas-6}...RFP::SAS-6
Sas-6M440A.UASp.Tag:FLAG
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0367819
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Sas-6
Name: Sas-6M440A.UASp.Tag:FLAG
Construct Expressed Component: Sas-6 (Dme)
Symbol: Sas-6M440A.UASp.Tag:FLAG
Sas-6UAS.Sas-6.GFP
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0221158
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Sas-6
Name: Sas-6UAS.Sas-6.GFP
Construct Expressed Component: Sas-6 (Dme)
Construct Regulatory Region: Sas-6 (Dme)
Symbol: Sas-6UAS.Sas-6.GFP
Sas-6F143D.GFP
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0403070
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Sas-6
Name: Sas-6F143D.GFP
Construct Expressed Component: Sas-6 (Dme)
Construct Regulatory Region: Sas-6 (Dme)
Symbol: Sas-6F143D.GFP
Sas-6mNeonGreen.C
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0376240
Genes: Sas-6 (Dme)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Sas-6
Gene Synonyms: sas-6...Sas-6...SAS-6
Genes: Sas-6 (Dme)
Name: Sas-6mNeonGreen.C
Symbol: Sas-6mNeonGreen.C
Sas-6Ubi.cHa.GFP
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0385463
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Sas-6
Name: Sas-6Ubi.cHa.GFP
Construct Expressed Component: Sas-6 (Dme)
Symbol: Sas-6Ubi.cHa.GFP
Constructs: ubi-GFP::SAS-6
Sas-6EGFP
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0319843
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Sas-6
Name: Sas-6EGFP
Construct Expressed Component: Sas-6 (Dme)
Construct Regulatory Region: Sas-6 (Dme)
Symbol: Sas-6EGFP
Constructs: PBac{GFP-Sas-6}...GFP::Sas-6
Sas-6Ubi.RFP(Unk)
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0356123
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Sas-6
Name: Sas-6Ubi.RFP(Unk)
Construct Expressed Component: Sas-6 (Dme)
Symbol: Sas-6Ubi.RFP(Unk)
Constructs: P{Ubi-RFP-Sas-6}...Ubq-RFP-Sas-6
Sas-6UAS.Sas-6.EGFP
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0343974
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Sas-6
Name: Sas-6UAS.Sas-6.EGFP
Construct Expressed Component: Sas-6 (Dme)
Construct Regulatory Region: Sas-6 (Dme)
Symbol: Sas-6UAS.Sas-6.EGFP
Sas-6NIG.15524R
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0272230
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Sas-6
Construct Knockdown Component: Sas-6 (Dme)
Name: Sas-6NIG.15524R
Symbol: Sas-6NIG.15524R
Sas-6L447A.UASp.Tag:FLAG
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0367818
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Sas-6
Name: Sas-6L447A.UASp.Tag:FLAG
Construct Expressed Component: Sas-6 (Dme)
Symbol: Sas-6L447A.UASp.Tag:FLAG
Sas-6KK102013
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0259080
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Sas-6
Construct Knockdown Component: Sas-6 (Dme)
Name: Sas-6KK102013
Symbol: Sas-6KK102013
Sas-6Ubi.C.GFP
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0386204
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Sas-6
Name: Sas-6Ubi.C.GFP
Construct Expressed Component: Sas-6 (Dme)
Symbol: Sas-6Ubi.C.GFP
Sas-6unspecified
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0386205
Genes: Sas-6 (Dme)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Sas-6
Gene Synonyms: sas-6...Sas-6...SAS-6
Genes: Sas-6 (Dme)
Name: Sas-6unspecified
Symbol: Sas-6unspecified
Sas-6F143D.Ubi.GFP
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0388714
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Sas-6
Name: Sas-6F143D.Ubi.GFP
Construct Expressed Component: Sas-6 (Dme)
Symbol: Sas-6F143D.Ubi.GFP
Sas-6UASp.GFP
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0240463
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Sas-6
Name: Sas-6UASp.GFP
Construct Expressed Component: Sas-6 (Dme)
Symbol: Sas-6UASp.GFP
Sas-6GD9045
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0201380
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Sas-6
Construct Knockdown Component: Sas-6 (Dme)
Name: Sas-6GD9045
Symbol: Sas-6GD9045
Sas-6e01437
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0187059
Genes: Sas-6 (Dme)
Synonyms: Not Available
Variant Type: insertion
Molecular Consequence: coding_sequence_variant
Diseases: Not Available
Variant Name: Not Available
Symbol: Sas-6
Gene Synonyms: sas-6...Sas-6...SAS-6
Genes: Sas-6 (Dme)
Name: Sas-6e01437
Symbol: Sas-6e01437
Sas-6c02901
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0162156
Genes: Sas-6 (Dme)
Synonyms: Not Available
Variant Type: insertion
Molecular Consequence: coding_sequence_variant
Diseases: Not Available
Variant Name: Not Available
Symbol: Sas-6
Gene Synonyms: sas-6...Sas-6...SAS-6
Genes: Sas-6 (Dme)
Name: Sas-6c02901
Symbol: Sas-6c02901
Uuuu\SAS-6mCherry
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0219402
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Uuuu\SAS-6 (Dme)
Name: Uuuu\SAS-6mCherry
Construct Expressed Component: SAS-6
Construct Regulatory Region: SAS-6
Constructs: P{mCherry-SAS-6}...mCherry-SAS-6
sass6
(Danio rerio)Gene
Name: SAS-6 centriolar assembly protein
Synonyms: cellular atoll, sas-6, cea, wu:fb98c12, zgc:55668
Source: ZFIN:ZDB-GENE-040426-2784
Biotype: protein coding gene
Synonyms: sas-6...sas-6...sas-6...sas-6
Strict Orthology Symbols: Sas-6
SASS6
(Homo sapiens)Gene
Name: SAS-6 centriolar assembly protein
Synonyms: FLJ22097, spindle assembly defective protein 6, MGC119440, hsSAS-6, SAS6, spindle assembly abnormal protein 6 homolog, MCPH14, spindle assembly 6 homolog, SAS-6
Source: HGNC:25403
Biotype: protein coding gene
Synonyms: SAS-6...SAS-6...SAS-6
Strict Orthology Symbols: Sas-6
sass6.2
(Xenopus tropicalis)Gene
Name: SAS-6 centriolar assembly protein
Synonyms: sass6.2, SAS-6 centriolar assembly protein, SASS6
Source: Xenbase:XB-GENE-962704
Biotype: gene
Synonyms: SAS-6 centriolar assembly protein...SAS-6 centriolar assembly protein
Strict Orthology Symbols: Sas-6
sass6.2.L
(Xenopus laevis)Gene
Name: SAS-6 centriolar assembly protein
Synonyms: sass6.2.L, SAS-6 centriolar assembly protein, SASS6
Source: Xenbase:XB-GENE-962708
Biotype: gene
Synonyms: SAS-6 centriolar assembly protein...SAS-6 centriolar assembly protein
Sass6
(Rattus norvegicus)Gene
Name: SAS-6 centriolar assembly protein
Synonyms: uncharacterized LOC102555636, LOC102555636, LOC310807, spindle assembly 6 homolog (C. elegans), similar to 2810453L12Rik protein, spindle assembly 6 homolog, spindle assembly abnormal protein 6 homolog, RGD1306255
Source: RGD:1306255
Biotype: protein coding gene
Strict Orthology Symbols: Sas-6
Sass6
(Mus musculus)Gene
Name: SAS-6 centriolar assembly protein
Synonyms: RIKEN cDNA 2810453L12 gene, 2810453L12Rik, RGD1306255
Source: MGI:1920026
Biotype: protein coding gene
Strict Orthology Symbols: Sas-6
sas-5
(Caenorhabditis elegans)Gene
Name: Spindle ASsembly abnormal 5
Synonyms: F35B12.5, CELE_F35B12.5
Source: WB:WBGene00009385
Biotype: protein coding gene
Gene Synopsis: components throughout the cell cycle; SAS-5 localization to centrioles depends upon the ZYG-1 kinase and the SAS...protein, two proteins also required for centriole duplication; in turn, SAS-5 activity is required for SAS...-6 centriolar localization, as SAS-6 fails to localize properly in sas-5 mutant embryos; SAS-5 and SAS
sass6
(Xenopus tropicalis)Gene
Name: spindle assembly 6 homolog
Synonyms: sass6, spindle assembly 6 homolog
Source: Xenbase:XB-GENE-5783525
Biotype: gene
Strict Orthology Symbols: Sas-6
EU3206
(Caenorhabditis elegans)Model
Id: WB:WBStrain00047273
Synonyms: Not Available
Genes: sas-6 (Cel)
or1167
(Caenorhabditis elegans)Allele/Variant
Source: WB:WBVar00601054
Genes: sas-6 (Cel)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Genes: sas-6 (Cel)
Source: DOID:0070279
Definition: A primary autosomal recessive microcephaly that has_material_basis_in homozygous or compound heterozygous mutation in the SASS6 gene on chromosome 1p21.
Genes: Sas-6 (Dme)
p37mfa
(Danio rerio)Allele/Variant
Source: ZFIN:ZDB-ALT-040224-6
Genes: sass6 (Dre)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Gene Synonyms: sas-6
zyg-1
(Caenorhabditis elegans)Gene
Name: ZYGote defective : embryonic lethal 1
Synonyms: CELE_F59E12.2, F59E12.2
Source: WB:WBGene00006988
Biotype: protein coding gene
Gene Synopsis: to each spindle assembly event; ZYG-1 activity is required for proper localization of the SAS-5 and SAS
Gene Ontology
Source: GO:0032053
Synonyms:
- microtubule basal body organisation
- microtubule basal body organization
Branch: biological process
Genes: Sas-6 (Dme)
Gene Ontology
Source: GO:0098534
Synonyms: Not Available
Branch: biological process
Genes: Sas-6 (Dme)
Gene Ontology
Source: GO:0010457
Synonyms: Not Available
Branch: biological process
Genes: Sas-6 (Dme)
Blan\blFP-Y3mNeonGreen.Sas-6
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0376159
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Construct Regulatory Region: Sas-6 (Dme)
Constructs: p(Sas-6)-mNG
Gene Ontology
Source: GO:0007099
Synonyms:
- centriole duplication
- ciliary basal body duplication
Branch: biological process
Genes: Sas-6 (Dme)...sas-6 (Cel)
WBPaper00035594Ex2
(Caenorhabditis elegans)Allele/Variant
Source: WB:WBTransgene00006147
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Construct Expressed Component: sas-6 (Cel)
Constructs: [Ppie-1::gfp-sas-6(S123A)]
Gene Ontology
Source: GO:0051298
Synonyms:
- centrosome replication
Branch: biological process
Genes: Sas-6 (Dme)
Gene Ontology
Source: GO:0071539
Synonyms:
- protein localisation to centrosome
Branch: biological process
Genes: Sas-6 (Dme)
Gene Ontology
Source: GO:0043232
Synonyms:
- intracellular non-membrane-bounded organelle
- intracellular non-membrane-enclosed organelle
Branch: cellular component
Genes: sas-6 (Cel)