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1,130 results for setd1b

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Setd1b

(Rattus norvegicus)

Gene

Name: SET domain containing 1B, histone lysine methyltransferase

Synonyms: histone-lysine N-methyltransferase SETD1B, SET domain containing 1B, LOC100359816, rCG21620-like

Source: RGD:2323325

Biotype: protein coding gene

Symbol: Setd1b (Rno)

Symbol: Setd1b

Gene Synopsis: Orthologous to human SETD1B (SET domain containing 1B, histone lysine methyltransferase); PARTICIPATES

Automated Gene Synopsis: Orthologous to human SETD1B (SET domain containing 1B, histone lysine methyltransferase).

Synonyms: histone-lysine N-methyltransferase SETD1B

Strict Orthology Symbols: setd1b

Setd1b

(Mus musculus)

Gene

Name: SET domain containing 1B

Synonyms: mKIAA1076, KMT2G, BC035291, MGC:39035, AA516740, cDNA sequence BC035291, expressed sequence AA516740

Source: MGI:2652820

Biotype: protein coding gene

Symbol: Setd1b (Mmu)

Symbol: Setd1b

Automated Gene Synopsis: Orthologous to human SETD1B (SET domain containing 1B, histone lysine methyltransferase).

Strict Orthology Symbols: setd1b

Alleles: Setd1b (Mmu)...Setd1b (Mmu)...Setd1b (Mmu)...Setd1b (Mmu)...Setd1b (Mmu)

SETD1B

(Homo sapiens)

Gene

Name: SET domain containing 1B, histone lysine methyltransferase

Synonyms: FLJ20803, hSET1B, Set1B, KMT2G, histone-lysine N-methyltransferase SETD1B, SET domain containing 1B, lysine N-methyltransferase 2G, IDDSELD, SET domain-containing protein 1B, KIAA1076

Source: HGNC:29187

Biotype: protein coding gene

Symbol: SETD1B (Hsa)

Symbol: SETD1B

Synonyms: histone-lysine N-methyltransferase SETD1B

Strict Orthology Symbols: setd1b

setd1b

(Xenopus tropicalis)

Gene

Name: SET domain containing 1B

Synonyms: setd1b, SET domain containing 1B

Source: Xenbase:XB-GENE-5842344

Biotype: gene

Symbol: setd1b (Xtr)

Symbol: setd1b

Automated Gene Synopsis: Orthologous to human SETD1B (SET domain containing 1B, histone lysine methyltransferase).

Synonyms: setd1b...setd1b...setd1b

Strict Orthology Symbols: Setd1b...setd1b.L...SETD1B...setd1ba...setd1bb

Disease (1)

setd1bb

(Danio rerio)

Gene

Name: SET domain containing 1B, histone lysine methyltransferase b

Synonyms: Not Available

Source: ZFIN:ZDB-GENE-080522-1

Biotype: protein coding gene

Symbol: setd1bb (Dre)

Automated Gene Synopsis: Orthologous to human SETD1B (SET domain containing 1B, histone lysine methyltransferase).

Strict Orthology Symbols: setd1b

Symbol: setd1bb

setd1ba

(Danio rerio)

Gene

Name: SET domain containing 1B, histone lysine methyltransferase a

Synonyms: si:dkey-237o15.4, im:7156157

Source: ZFIN:ZDB-GENE-050309-289

Biotype: protein coding gene

Symbol: setd1ba (Dre)

Automated Gene Synopsis: Orthologous to human SETD1B (SET domain containing 1B, histone lysine methyltransferase).

Strict Orthology Symbols: setd1b

Symbol: setd1ba

setd1b.S

(Xenopus laevis)

Gene

Name: SET domain containing 1B

Synonyms: SET domain containing 1B, setd1b.S

Source: Xenbase:XB-GENE-5842376

Biotype: gene

Symbol: setd1b.S (Xla)

Automated Gene Synopsis: Orthologous to human SETD1B (SET domain containing 1B, histone lysine methyltransferase).

Strict Orthology Symbols: setd1b

Symbol: setd1b.S

setd1b.L

(Xenopus laevis)

Gene

Name: SET domain containing 1B

Synonyms: SET domain containing 1B, setd1b.L

Source: Xenbase:XB-GENE-17346666

Biotype: gene

Symbol: setd1b.L (Xla)

Automated Gene Synopsis: Orthologous to human SETD1B (SET domain containing 1B, histone lysine methyltransferase).

Strict Orthology Symbols: setd1b

Symbol: setd1b.L

Setd1b^{tm2.2(IMPC)Wtsi}

(Mus musculus)

Allele/Variant

Source: MGI:7861524

Genes: Setd1b (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Setd1b (Mmu)

Genes: Setd1b (Mmu)

Symbol: Setd1b^{tm2.2(IMPC)Wtsi}

Gene (1)

Setd1b^tm1.3Afst

(Mus musculus)

Allele/Variant

Source: MGI:5568945

Genes: Setd1b (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Setd1b (Mmu)

Genes: Setd1b (Mmu)

Symbol: Setd1b^tm1.3Afst

Setd1b^em1Smoc

(Mus musculus)

Allele/Variant

Source: MGI:7766659

Genes: Setd1b (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Setd1b (Mmu)

Genes: Setd1b (Mmu)

Symbol: Setd1b^em1Smoc

Gene (1)

Setd1b^em2Cya

(Mus musculus)

Allele/Variant

Source: MGI:7586446

Genes: Setd1b (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Setd1b (Mmu)

Genes: Setd1b (Mmu)

Symbol: Setd1b^em2Cya

Gene (1)

Setd1b^tm1.2Afst

(Mus musculus)

Allele/Variant

Source: MGI:5568944

Genes: Setd1b (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Setd1b (Mmu)

Genes: Setd1b (Mmu)

Symbol: Setd1b^tm1.2Afst

Gene (1)

Setd1b^em4Gpt

(Mus musculus)

Allele/Variant

Source: MGI:7305976

Genes: Setd1b (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Setd1b (Mmu)

Genes: Setd1b (Mmu)

Symbol: Setd1b^em4Gpt

Gene (1)

Setd1b^tm1Afst

(Mus musculus)

Allele/Variant

Source: MGI:5568942

Genes: Setd1b (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Setd1b (Mmu)

Genes: Setd1b (Mmu)

Symbol: Setd1b^tm1Afst

Gene (1)

Setd1b^tm1.1Afst

(Mus musculus)

Allele/Variant

Source: MGI:5568943

Genes: Setd1b (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Setd1b (Mmu)

Genes: Setd1b (Mmu)

Symbol: Setd1b^tm1.1Afst

Setd1b^tm1.1Afst/Setd1b^tm1.1Afst [background:] involves: 129S1/Sv * 129X1/SvJ * C57BL/6

(Mus musculus)

Model

Id: MGI:5568955

Synonyms: Not Available

Symbol: Setd1b/Setd1b [background:] involves: 129S1/Sv * 129X1/SvJ * C57BL/6 (Mmu)

Genes: Setd1b (Mmu)

Alleles: Setd1b (Mmu)

Name: Setd1b/Setd1b [background:] involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Gene (1)

Setd1b^tm1.3Afst/Setd1b^tm1.3Afst [background:] involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

(Mus musculus)

Model

Id: MGI:5568956

Synonyms: Not Available

Symbol: Setd1b/Setd1b [background:] involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

Genes: Setd1b (Mmu)

Alleles: Setd1b (Mmu)

Name: Setd1b/Setd1b [background:] involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

Gene (1)

set-2

(Caenorhabditis elegans)

Gene

Name: SET (trithorax/polycomb) domain containing 2

Synonyms: CELE_C26E6.9, C26E6.9

Source: WB:WBGene00004782

Biotype: protein coding gene

Automated Gene Synopsis: Orthologous to human SETD1A (SET domain containing 1A, histone lysine methyltransferase) and SETD1B (

Strict Orthology Symbols: setd1b

Set1

(Drosophila melanogaster)

Gene

Name: SET domain containing 1

Synonyms: lethal 5, aaf45425 Dm, dset1, dSet-1, l5, l(3)h5, SET1, SetD1, SET domain-containing 1, CG17395, lethal5, CG17396, CG40351, dSET1, set1, dSet1, SETD1

Source: FB:FBgn0040022

Biotype: protein coding gene

Automated Gene Synopsis: Orthologous to human SETD1A (SET domain containing 1A, histone lysine methyltransferase) and SETD1B (

Strict Orthology Symbols: setd1b

SET1

(Saccharomyces cerevisiae)

Gene

Name: SET domain-containing

Synonyms: KMT2, YHR119W, YTX1

Source: SGD:S000001161

Biotype: protein coding gene

Automated Gene Synopsis: Orthologous to human SETD1A (SET domain containing 1A, histone lysine methyltransferase) and SETD1B (

Strict Orthology Symbols: setd1b

Setd1a

(Rattus norvegicus)

Gene

Name: SET domain containing 1A, histone lysine methyltransferase

Synonyms: histone-lysine N-methyltransferase SETD1A, LOC309001, SET domain containing 1A, SET domain containing 1B, Setd1b, RGD1311624, similar to KIAA0339 protein

Source: RGD:1311624

Biotype: protein coding gene

Synonyms: Setd1b...Setd1b

neurodevelopmental disorder with speech impairment and dysmorphic facies

Disease

Source: DOID:0070417

Definition: A autosomal dominant intellectual developmental disorder characterized by developmental delay associated with mild to moderately impaired intellectual development or learning difficulties, behavioral or psychiatric abnormalities, and delayed speech and language acquisition that has_material_basis_in heterozygous mutation in the SETD1A gene on chromosome 16p11.

Genes: SETD1B (Hsa)...setd1bb (Dre)...Setd1b (Mmu)...setd1b (Xtr)...Setd1b (Rno)

histone H3K4 trimethyltransferase activity

Gene Ontology

Source: GO:0140999

Synonyms:

histone H3-K4 trimethylation
histone H3K4 trimethylase activity

Branch: molecular function

Genes: Setd1b (Mmu)...SETD1B (Hsa)...setd1ba (Dre)...Setd1b (Rno)

Genes Annotated with this GO Term (39)

histone H3K4 methyltransferase activity

Gene Ontology

Source: GO:0042800

Synonyms:

histone H3 lysine 4-specific methyltransferase activity
histone H3K4 methylase activity

Branch: molecular function

Genes: Setd1b (Mmu)...setd1bb (Dre)...SETD1B (Hsa)...setd1ba (Dre)...Setd1b (Rno)

Genes Annotated with this GO Term (108)

Set1C/COMPASS complex

Gene Ontology

Source: GO:0048188

Synonyms:

COMPASS complex
Set1/COMPASS complex

Branch: cellular component

Genes: Setd1b (Mmu)...setd1bb (Dre)...SETD1B (Hsa)...setd1ba (Dre)...Setd1b (Rno)

Definition: Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B

Genes Annotated with this GO Term (92)

histone H3K4 monomethyltransferase activity

Gene Ontology

Source: GO:0140945

Synonyms:

histone H3K4 monomethylase activity
histone H4-K4 methylation

Branch: molecular function

Genes: Setd1b (Mmu)...SETD1B (Hsa)

Genes Annotated with this GO Term (28)

Postnatal SETD1B is essential for learning and the regulation of neuronal plasticity genes [WT scRNA-seq]

(Mus musculus)

HTP Dataset Index

High-Throughput (HTP) Dataset Index metadata provided by MGI

ID: ArrayExpress:GSE185182

Tags: baseline

Summary: Histone 3 lysine 4 methylation (H3K4me) is mediated by six different lysine methyltransferases. Amongst these enzymes SET domain containing 1b (SETD1B) has been linked to syndromic intellectual disability but its role in the postnatal brain has not been studied yet. Here we employ mice that lack Setd1b from excitatory neurons of the postnatal forebrain and combine neuron-specific ChIP-seq and RNA-seq approaches to elucidate its role in neuronal gene expression. We observe that SETD1B controls the expression of genes with a broad H3K4me3 peak at their promoters that represent neuronal enriched genes linked to learning and memory function. Comparative analysis to corresponding data from conditional Kmt2a and Kmt2b knockout mice suggests that this function is specific to SETD1B. Moreover, postnatal loss of Setd1b leads to severe learning impairment, suggesting that SETD1B-mediated regulation of H3K4me levels in postnatal neurons is critical for cognitive function. Single nuclei RNA sequencing from hippocampus of wildtype young mice.

Symbol: Postnatal SETD1B is essential for learning and the regulation of neuronal plasticity genes [WT scRNA-seq

Name: Postnatal SETD1B is essential for learning and the regulation of neuronal plasticity genes [WT scRNA-seq

Postnatal SETD1B is essential for learning and the regulation of neuronal plasticity genes

(Mus musculus)

HTP Dataset Index

High-Throughput (HTP) Dataset Index metadata provided by MGI

ID: ArrayExpress:GSE180326

Tags: WT vs. mutant, anatomical structure, genotype

Summary: We have analyzed changes in histone 3 lysine 4 methylation (H3K4me3 and H3K4me1), histone acetylation (H3K9ac and H3K27ac) and gene expression resulting from Setd1b knockdown in adult hippocampal CA neurons in mice. We implemented Cre/loxP-mediated conditional knockout strategy in order to knockdown this histone methyltransferase in excitatory forebrain neurons in adult mice. Examination of H3K4me3, H3K4me1, H3K9ac and H3K27ac levels, and gene expression in hippocampal CA neurons of adult Setd1b cKO mice.

Symbol: Postnatal SETD1B is essential for learning and the regulation of neuronal plasticity genes

Name: Postnatal SETD1B is essential for learning and the regulation of neuronal plasticity genes

Loss of SETD1B results in the redistribution of genomic H3K4me3 in the oocyte [RNA-seq]

(Mus musculus)

HTP Dataset Index

High-Throughput (HTP) Dataset Index metadata provided by MGI

ID: ArrayExpress:GSE167984

Tags: WT vs. mutant, genotype

Summary: Histone 3 lysine 4 trimethylation (H3K4me3) is an epigenetic mark found at active gene promoters and CpG islands. H3K4me3 is essential for mammalian development, yet mechanisms underlying its genomic targeting are poorly understood. H3K4me3 methyltransferases SETD1B and MLL2 are essential for oogenesis. We investigated changes in H3K4me3 in Setd1b conditional knockout (cKO) GV oocytes using ultra-low input ChIP-seq, in complement to DNA methylation and gene expression analysis. Setd1b cKO oocytes showed a redistribution of H3K4me3, with a marked loss at active gene promoters associated with downregulated gene expression. Remarkably, many regions gained H3K4me3 in Setd1b cKOs, in particular those that were DNA hypomethylated, transcriptionally inactive and CpG-rich. All of these are hallmarks of MLL2 targets; thus, loss of SETD1B appears to enable enhanced MLL2 activity. Our work reveals two distinct, complementary mechanisms of genomic targeting of H3K4me3 in oogenesis, with SETD1B linked to transcriptional activity and MLL2 to CpG content. Single GV oocytes were collected from females with an oocyte conditional deletion of Setd1b using Gdf9-cre (Setd1b cKO) and females carrying floxed Setd1b (Setd1b WT) for single cell RNA-seq for four and three biological replicates, respectively.

Symbol: Loss of SETD1B results in the redistribution of genomic H3K4me3 in the oocyte [RNA-seq]

Name: Loss of SETD1B results in the redistribution of genomic H3K4me3 in the oocyte [RNA-seq]

histone methyltransferase complex

Gene Ontology

Source: GO:0035097

Synonyms: Not Available

Branch: cellular component

Genes: Setd1b (Mmu)...SETD1B (Hsa)...Setd1b (Rno)

Genes Annotated with this GO Term (346)

The histone 3 lysine 4 methyltransferase Setd1b is a maternal effect gene required for the oogenic gene expression program

(Mus musculus)

HTP Dataset Index

High-Throughput (HTP) Dataset Index metadata provided by MGI

ID: ArrayExpress:GSE85360

Tags: WT vs. mutant, genotype

Summary: Germ cell development involves major reprogramming of the epigenome to prime the zygote for totipotency. Histone 3 lysine 4 (H3K4) methylations are universal epigenetic marks mediated in mammals by six H3K4 methyltransferases related to fly Trithorax, including two yeast Set1 orthologs: Setd1a and Setd1b. Whereas Setd1a plays no role in oogenesis, we report that Setd1b deficiency causes female sterility. Oocyte specific Gdf9iCre conditional knockout (Setd1bGdf9cKO) ovaries develop through all stages however follicular loss accumulated with age and unfertilized metaphase II (MII) oocytes exhibited irregularities of the zona pellucida and meiotic spindle. Most Setd1bGdf9cKO zygotes remained in the pronuclear stage and displayed polyspermy in the perivitelline space. Expression profiling of Setd1bGdf9cKO MII oocytes revealed (i) that Setd1b promotes the expression of the major oocyte transcription factors including Obox1, 2, 5, 7, Meis2 and Sall4; and (ii) two-times more up- than downregulated mRNAs suggesting that Setd1b also promotes the expression of negative regulators of oocyte development with multiple Zfp-KRAB factors implicated. Together, these findings indicate that Setd1b serves as maternal effect gene through regulation of the oocyte gene expression program. Oocyte RNA profiling for Setd1bGdf9cKO and control mice

Symbol: The histone 3 lysine 4 methyltransferase Setd1b is a maternal effect gene required for the oogenic gene

Name: The histone 3 lysine 4 methyltransferase Setd1b is a maternal effect gene required for the oogenic gene