Version: 8.1.0
Date: Fri Apr 18 2025
64 results for spas-1

spas-1

(Caenorhabditis elegans)
Gene
Name: SPAStin (human neurodegeneration-associated AAA ATPase) related 1
Synonyms: C24B5.2, CELE_C24B5.2, C. elegans spastin
Source: WB:WBGene00016045
Biotype: protein coding gene
Symbol: spas-1 (Cel)
Symbol: spas-1
Gene Synopsis: spas-1 is an ortholog of human SPAST (spastin); spas-1 is involved in microtubule depolymerization, microtubule...severing, oogenesis, protein homooligomerization and vulval development; spas-1 exhibits microtubule...binding activity and microtubule-severing ATPase activity; epidermal expression of SPAS-1 triggers mild...effects on embryonic elongation, which are dramatically enhanced by let-502 weak loss of function; spas...-1 is expressed throughout the body including the gonad, intestine, and the vulva; spas-1 is localized
Cross References: spas-1...WB:spas-1...spas-1

SPAST

(Homo sapiens)
Gene
Name: spastin
Synonyms: spastic paraplegia 4 (autosomal dominant, spastin), spastic paraplegia 4 (autosomal dominant), spastic paraplegia 4 protein, SPG4, KIAA1083, FSP2, ADPSP
Source: HGNC:11233
Biotype: protein coding gene
Strict Orthology Symbols: spas-1

YTA6

(Saccharomyces cerevisiae)
Gene
Name: Yeast Tat-binding Analog
Synonyms: YPL074W
Source: SGD:S000005995
Biotype: protein coding gene
Strict Orthology Symbols: spas-1

spas

(Drosophila melanogaster)
Gene
Name: spastin
Synonyms: spasin, spastin, D-Spastin, SPAST, Spas, SPAS, Spastin, D-spastin, Dm-Spastin, Dspastin, CG5977
Source: FB:FBgn0039141
Biotype: protein coding gene
Strict Orthology Symbols: spas-1

spast

(Danio rerio)
Gene
Name: spastin
Synonyms: zgc:85952, spg4
Source: ZFIN:ZDB-GENE-040426-2331
Biotype: protein coding gene
Strict Orthology Symbols: spas-1

Spast

(Mus musculus)
Gene
Name: spastin
Synonyms: spastic paraplegia 4 homolog (human), mKIAA1083, Spg4
Source: MGI:1858896
Biotype: protein coding gene
Strict Orthology Symbols: spas-1

Spast

(Rattus norvegicus)
Gene
Name: spastin
Synonyms: spastic paraplegia 4 (autosomal dominant, spastin), spastic paraplegia 4 (autosomal dominant), spastic paraplegia 4 (autosomal dominant, Spg4, LOC362700
Source: RGD:1308494
Biotype: protein coding gene
Strict Orthology Symbols: spas-1

spast

(Xenopus tropicalis)
Gene
Name: spastin
Synonyms: spastin, spast
Source: Xenbase:XB-GENE-947839
Biotype: gene
Strict Orthology Symbols: spas-1

FX683

(Caenorhabditis elegans)
Model
Id: WB:WBStrain00007567
Synonyms: Not Available
Genes: spas-1 (Cel)

tm683

(Caenorhabditis elegans)
Allele/Variant
Source: WB:WBVar00249713
Genes: spas-1 (Cel)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: hereditary spastic paraplegia
Variant Name: Not Available
Genes: spas-1 (Cel)

hereditary spastic paraplegia 4

Disease
Source: DOID:0110792
Definition: A hereditary spastic paraplegia that is characterized by slowly progressive muscle weakness and spasticity and has_material_basis_in mutation in the SPAST gene on chromosome 2p22.
Genes: spas-1 (Cel)

positive regulation of microtubule depolymerization

Gene Ontology
Source: GO:0031117
Synonyms:
  • activation of microtubule depolymerization
  • microtubule destabilization
Branch: biological process
Genes: spas-1 (Cel)

microtubule severing

Gene Ontology
Source: GO:0051013
Synonyms:
  • microtubule severing activity
Branch: biological process
Genes: spas-1 (Cel)

nucleus localization

Gene Ontology
Source: GO:0051647
Synonyms:
  • cell nucleus localization
  • establishment and maintenance of nucleus localization
Branch: biological process
Genes: spas-1 (Cel)

microtubule severing ATPase activity

Gene Ontology
Source: GO:0008568
Synonyms:
  • ATP phosphohydrolase (tubulin-dimerizing)
  • katanin activity
Branch: molecular function
Genes: spas-1 (Cel)

vulval development

Gene Ontology
Source: GO:0040025
Synonyms: Not Available
Branch: biological process
Genes: spas-1 (Cel)

microtubule depolymerization

Gene Ontology
Source: GO:0007019
Synonyms:
  • microtubule catastrophe
  • microtubule depolymerization during nuclear congression
Branch: biological process
Genes: spas-1 (Cel)

microtubule bundle formation

Gene Ontology
Source: GO:0001578
Synonyms:
  • microtubule bundling
Branch: biological process
Genes: spas-1 (Cel)

hereditary spastic paraplegia

Disease
Source: DOID:2476
Definition: A paraplegia that is characterized by progressive stiffness and contraction (spasticity) in the lower limbs.
Genes: spas-1 (Cel)

oogenesis

Gene Ontology
Source: GO:0048477
Synonyms:
  • ovum development
Branch: biological process
Genes: spas-1 (Cel)

isomerase activity

Gene Ontology
Source: GO:0016853
Synonyms:
  • other isomerase activity
Branch: molecular function
Genes: spas-1 (Cel)

microtubule cytoskeleton organization

Gene Ontology
Source: GO:0000226
Synonyms:
  • microtubule cytoskeleton organisation
  • microtubule cytoskeleton organization and biogenesis
Branch: biological process
Genes: spas-1 (Cel)

microtubule cytoskeleton

Gene Ontology
Source: GO:0015630
Synonyms: Not Available
Branch: cellular component
Genes: spas-1 (Cel)

microtubule binding

Gene Ontology
Source: GO:0008017
Synonyms:
  • microtubule severing activity
  • microtubule/chromatin interaction
Branch: molecular function
Genes: spas-1 (Cel)

microtubule

Gene Ontology
Source: GO:0005874
Synonyms:
  • microtubuli
  • microtubulus
Branch: cellular component
Genes: spas-1 (Cel)

nervous system development

Gene Ontology
Source: GO:0007399
Synonyms:
  • pan-neural process
Branch: biological process
Genes: spas-1 (Cel)

ATP hydrolysis activity

Gene Ontology
Source: GO:0016887
Synonyms:
  • ATP hydrolase activity
  • ATP monophosphatase activity
Branch: molecular function
Genes: spas-1 (Cel)

perinuclear region of cytoplasm

Gene Ontology
Source: GO:0048471
Synonyms: Not Available
Branch: cellular component
Genes: spas-1 (Cel)

(WBcel235)V:9176880G>A

(Caenorhabditis elegans)
Allele/Variant
Source: NC_003283.11:g.9176880G>A
Genes: spas-1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (WBcel235)V:9176880G>A
Gene Cross References: spas-1

(WBcel235)V:9177299G>A

(Caenorhabditis elegans)
Allele/Variant
Source: NC_003283.11:g.9177299G>A
Genes: spas-1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (WBcel235)V:9177299G>A
Gene Cross References: spas-1

(WBcel235)V:9176299G>A

(Caenorhabditis elegans)
Allele/Variant
Source: NC_003283.11:g.9176299G>A
Genes: spas-1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: non_coding_transcript_exon_variant, synonymous_variant
Diseases: Not Available
Variant Name: (WBcel235)V:9176299G>A
Gene Cross References: spas-1

(WBcel235)V:9177066C>T

(Caenorhabditis elegans)
Allele/Variant
Source: NC_003283.11:g.9177066C>T
Genes: spas-1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (WBcel235)V:9177066C>T
Gene Cross References: spas-1

(WBcel235)V:9176737G>A

(Caenorhabditis elegans)
Allele/Variant
Source: NC_003283.11:g.9176737G>A
Genes: spas-1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (WBcel235)V:9176737G>A
Gene Cross References: spas-1

(WBcel235)V:9177701C>T

(Caenorhabditis elegans)
Allele/Variant
Source: NC_003283.11:g.9177701C>T
Genes: spas-1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: non_coding_transcript_variant, intron_variant
Diseases: Not Available
Variant Name: (WBcel235)V:9177701C>T
Gene Cross References: spas-1

(WBcel235)V:9177412T>C

(Caenorhabditis elegans)
Allele/Variant
Source: NC_003283.11:g.9177412T>C
Genes: spas-1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: non_coding_transcript_exon_variant, synonymous_variant
Diseases: Not Available
Variant Name: (WBcel235)V:9177412T>C
Gene Cross References: spas-1

(WBcel235)V:9177793G>A

(Caenorhabditis elegans)
Allele/Variant
Source: NC_003283.11:g.9177793G>A
Genes: spas-1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (WBcel235)V:9177793G>A
Gene Cross References: spas-1

(WBcel235)V:9177245G>A

(Caenorhabditis elegans)
Allele/Variant
Source: NC_003283.11:g.9177245G>A
Genes: spas-1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (WBcel235)V:9177245G>A
Gene Cross References: spas-1

(WBcel235)V:9176725A>G

(Caenorhabditis elegans)
Allele/Variant
Source: NC_003283.11:g.9176725A>G
Genes: spas-1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (WBcel235)V:9176725A>G
Gene Cross References: spas-1

(WBcel235)V:9177358A>G

(Caenorhabditis elegans)
Allele/Variant
Source: NC_003283.11:g.9177358A>G
Genes: spas-1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: non_coding_transcript_exon_variant, synonymous_variant
Diseases: Not Available
Variant Name: (WBcel235)V:9177358A>G
Gene Cross References: spas-1

(WBcel235)V:9176747G>C

(Caenorhabditis elegans)
Allele/Variant
Source: NC_003283.11:g.9176747G>C
Genes: spas-1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: non_coding_transcript_exon_variant, synonymous_variant
Diseases: Not Available
Variant Name: (WBcel235)V:9176747G>C
Gene Cross References: spas-1

(WBcel235)V:9176142G>A

(Caenorhabditis elegans)
Allele/Variant
Source: NC_003283.11:g.9176142G>A
Genes: spas-1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: non_coding_transcript_exon_variant, synonymous_variant
Diseases: Not Available
Variant Name: (WBcel235)V:9176142G>A
Gene Cross References: spas-1

(WBcel235)V:9176811A>C

(Caenorhabditis elegans)
Allele/Variant
Source: NC_003283.11:g.9176811A>C
Genes: spas-1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: non_coding_transcript_variant, intron_variant
Diseases: Not Available
Variant Name: (WBcel235)V:9176811A>C
Gene Cross References: spas-1

(WBcel235)V:9177212G>A

(Caenorhabditis elegans)
Allele/Variant
Source: NC_003283.11:g.9177212G>A
Genes: spas-1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: non_coding_transcript_variant, splice_acceptor_variant
Diseases: Not Available
Variant Name: (WBcel235)V:9177212G>A
Gene Cross References: spas-1

(WBcel235)V:9177289C>T

(Caenorhabditis elegans)
Allele/Variant
Source: NC_003283.11:g.9177289C>T
Genes: spas-1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: non_coding_transcript_exon_variant, synonymous_variant
Diseases: Not Available
Variant Name: (WBcel235)V:9177289C>T
Gene Cross References: spas-1

(WBcel235)V:9177847G>A

(Caenorhabditis elegans)
Allele/Variant
Source: NC_003283.11:g.9177847G>A
Genes: spas-1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: 3_prime_UTR_variant
Diseases: Not Available
Variant Name: (WBcel235)V:9177847G>A
Gene Cross References: spas-1

(WBcel235)V:9176261G>A

(Caenorhabditis elegans)
Allele/Variant
Source: NC_003283.11:g.9176261G>A
Genes: spas-1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (WBcel235)V:9176261G>A
Gene Cross References: spas-1

(WBcel235)V:9176521G>A

(Caenorhabditis elegans)
Allele/Variant
Source: NC_003283.11:g.9176521G>A
Genes: spas-1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: non_coding_transcript_exon_variant, synonymous_variant, intron_variant
Diseases: Not Available
Variant Name: (WBcel235)V:9176521G>A
Gene Cross References: spas-1

(WBcel235)V:9175895G>A

(Caenorhabditis elegans)
Allele/Variant
Source: NC_003283.11:g.9175895G>A
Genes: spas-1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: non_coding_transcript_exon_variant, synonymous_variant
Diseases: Not Available
Variant Name: (WBcel235)V:9175895G>A
Gene Cross References: spas-1

(WBcel235)V:9176035T>C

(Caenorhabditis elegans)
Allele/Variant
Source: NC_003283.11:g.9176035T>C
Genes: spas-1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: non_coding_transcript_exon_variant, synonymous_variant
Diseases: Not Available
Variant Name: (WBcel235)V:9176035T>C
Gene Cross References: spas-1

(WBcel235)V:9177254G>A

(Caenorhabditis elegans)
Allele/Variant
Source: NC_003283.11:g.9177254G>A
Genes: spas-1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (WBcel235)V:9177254G>A
Gene Cross References: spas-1