Version: 8.0.0Date: Tue Jan 28 2025
Category
Timp3
(Rattus norvegicus)Gene
Name: TIMP metallopeptidase inhibitor 3
Synonyms: metalloproteinase inhibitor 3, TIMP-3, tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory), tissue inhibitor of metalloproteinases 3, tissue inhibitor of metalloproteinase 3
Source: RGD:3865
Biotype: protein coding gene
Symbol: Timp3 (Rno)
Symbol: Timp3
Gene Synopsis: Orthologous to human TIMP3 (TIMP metallopeptidase inhibitor 3); PARTICIPATES IN angiotensin II signaling
Automated Gene Synopsis: Orthologous to human TIMP3 (TIMP metallopeptidase inhibitor 3).
Strict Orthology Symbols: timp3
Timp3
(Mus musculus)Gene
Name: tissue inhibitor of metalloproteinase 3
Synonyms: Timp-3
Source: MGI:98754
Biotype: protein coding gene
Symbol: Timp3 (Mmu)
Symbol: Timp3
Automated Gene Synopsis: Orthologous to human TIMP3 (TIMP metallopeptidase inhibitor 3).
Strict Orthology Symbols: timp3
Alleles: Timp3
TIMP3
(Homo sapiens)Gene
Name: TIMP metallopeptidase inhibitor 3
Synonyms: SFD, K222TA2, metalloproteinase inhibitor 3, TIMP-3, TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory), HSMRK222, tissue inhibitor of metalloproteinases 3, protein MIG-5, K222, tissue inhibitor of metalloproteinase 3, MIG-5 protein
Source: HGNC:11822
Biotype: protein coding gene
Symbol: TIMP3 (Hsa)
Symbol: TIMP3
Strict Orthology Symbols: timp3
timp3
(Xenopus tropicalis)Gene
Name: TIMP metallopeptidase inhibitor 3
Synonyms: TIMP-3, TIMP metallopeptidase inhibitor 3, timp3-A, timp3
Source: Xenbase:XB-GENE-482400
Biotype: gene
Symbol: timp3 (Xtr)
Symbol: timp3
Automated Gene Synopsis: Orthologous to human TIMP3 (TIMP metallopeptidase inhibitor 3).
Synonyms: timp3...timp3...timp3
Strict Orthology Symbols: timp3.S...TIMP3...timp3.L...Timp3
timp3
(Danio rerio)Gene
Name: TIMP metallopeptidase inhibitor 3
Synonyms: Not Available
Source: ZFIN:ZDB-GENE-070824-3
Biotype: protein coding gene
Symbol: timp3 (Dre)
Symbol: timp3
timp3.S
(Xenopus laevis)Gene
Name: TIMP metallopeptidase inhibitor 3
Synonyms: TIMP-3, timp3.S, TIMP metallopeptidase inhibitor 3, timp3-A
Source: Xenbase:XB-GENE-17337079
Biotype: gene
Symbol: timp3.S (Xla)
Automated Gene Synopsis: Orthologous to human TIMP3 (TIMP metallopeptidase inhibitor 3).
Strict Orthology Symbols: timp3
Symbol: timp3.S
timp3.L
(Xenopus laevis)Gene
Name: TIMP metallopeptidase inhibitor 3
Synonyms: TIMP-3, TIMP metallopeptidase inhibitor 3, timp3.L, timp3-A
Source: Xenbase:XB-GENE-864869
Biotype: gene
Symbol: timp3.L (Xla)
Automated Gene Synopsis: Orthologous to human TIMP3 (TIMP metallopeptidase inhibitor 3).
Strict Orthology Symbols: timp3
Symbol: timp3.L
Timp3tm1(KOMP)Vlcg
(Mus musculus)Allele/Variant
Source: MGI:5051171
Genes: Timp3 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Timp3
Genes: Timp3 (Mmu)
Symbol: Timp3tm1(KOMP)Vlcg
Timp3em2Cya
(Mus musculus)Allele/Variant
Source: MGI:7587089
Genes: Timp3 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Timp3
Genes: Timp3 (Mmu)
Symbol: Timp3em2Cya
Timp3tm1Web
(Mus musculus)Allele/Variant
Source: MGI:2183790
Genes: Timp3 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Sorsby's fundus dystrophy
Variant Name: Not Available
Symbol: Timp3
Genes: Timp3 (Mmu)
Symbol: Timp3tm1Web
Timp3em1Cya
(Mus musculus)Allele/Variant
Source: MGI:7587088
Genes: Timp3 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Timp3
Genes: Timp3 (Mmu)
Symbol: Timp3em1Cya
Timp3tm1Rkho
(Mus musculus)Allele/Variant
Source: MGI:2387409
Genes: Timp3 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: dilated cardiomyopathy
Variant Name: Not Available
Symbol: Timp3
Genes: Timp3 (Mmu)
Symbol: Timp3tm1Rkho
Timp3em1Gpt
(Mus musculus)Allele/Variant
Source: MGI:7377385
Genes: Timp3 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Timp3
Genes: Timp3 (Mmu)
Symbol: Timp3em1Gpt
Timp3tm1Hest
(Mus musculus)Allele/Variant
Source: MGI:3797605
Genes: Timp3 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Timp3
Genes: Timp3 (Mmu)
Symbol: Timp3tm1Hest
Timp3tm1.1(KOMP)Vlcg
(Mus musculus)Allele/Variant
Source: MGI:5445932
Genes: Timp3 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Timp3
Genes: Timp3 (Mmu)
Symbol: Timp3tm1.1(KOMP)Vlcg
Timp3tm1Osya
(Mus musculus)Allele/Variant
Source: MGI:4398972
Genes: Timp3 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Timp3
Genes: Timp3 (Mmu)
Symbol: Timp3tm1Osya
Timp3tm1Rkho/Timp3tm1Rkho Tnftm1Gkl/Tnftm1Gkl [background:] involves: 129 * 129S/SvEv * C57BL/6
(Mus musculus)Model
Id: MGI:3664937
Synonyms: Not Available
Symbol: Timp3/Timp3 Tnf/Tnf [background:] involves: 129 * 129S/SvEv * C57BL
Genes: Timp3 (Mmu)
Alleles: Timp3
Name: Timp3/Timp3 Tnf/Tnf [background:] involves: 129 * 129S/SvEv * C57BL
Model
Id: MGI:4399117
Synonyms: Not Available
Symbol: Timp3/Timp3 [background:] involves: 129P2/OlaHsd * C57BL/6 (Mmu)
Genes: Timp3 (Mmu)
Alleles: Timp3
Name: Timp3/Timp3 [background:] involves: 129P2/OlaHsd * C57BL/6
Model
Id: MGI:5617484
Synonyms: Not Available
Symbol: Timp3/Timp3 [background:] involves: 129P2/OlaHsd * C57BL/6J (Mmu)
Genes: Timp3 (Mmu)
Alleles: Timp3
Name: Timp3/Timp3 [background:] involves: 129P2/OlaHsd * C57BL/6J
Timp3tm1Hest/Timp3tm1Hest [background:] either: B6.129S1-Timp3tm1Hest or (involves: 129S1/Sv * CD-1)
(Mus musculus)Model
Id: MGI:3799161
Synonyms: Not Available
Symbol: Timp3/Timp3 [background:] either: B6.129S1-Timp3 or (involves: 129S1/Sv *
Genes: Timp3 (Mmu)
Alleles: Timp3
Name: Timp3/Timp3 [background:] either: B6.129S1-Timp3 or (involves: 129S1/Sv *
Model
Id: MGI:3056102
Synonyms: Not Available
Symbol: Timp3/Timp3 [background:] FVB.129-Timp3 (Mmu)
Genes: Timp3 (Mmu)
Alleles: Timp3
Name: Timp3/Timp3 [background:] FVB.129-Timp3
Model
Id: MGI:3056103
Synonyms: Not Available
Symbol: Timp3/Timp3 [background:] B6.129-Timp3 (Mmu)
Genes: Timp3 (Mmu)
Alleles: Timp3
Name: Timp3/Timp3 [background:] B6.129-Timp3
Timp3tm1.1(KOMP)Vlcg/Timp3tm1.1(KOMP)Vlcg [background:] C57BL/6N-Timp3tm1.1(KOMP)Vlcg/J
(Mus musculus)Model
Id: MGI:5631622
Synonyms: Not Available
Symbol: Timp3/Timp3 [background:] C57BL/6N-Timp3/J (Mmu)
Genes: Timp3 (Mmu)
Alleles: Timp3
Name: Timp3/Timp3 [background:] C57BL/6N-Timp3/J
Timp3tm1Web/Timp3tm1Web [background:] either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)
(Mus musculus)Model
Id: MGI:3664350
Synonyms: Not Available
Symbol: Timp3/Timp3 [background:] either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)
Genes: Timp3 (Mmu)
Alleles: Timp3
Name: Timp3/Timp3 [background:] either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)
Timp3tm1Web/Timp3+ [background:] either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)
(Mus musculus)Model
Id: MGI:3664346
Synonyms: Not Available
Symbol: Timp3/Timp3<+> [background:] either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6) (Mmu
Genes: Timp3 (Mmu)
Alleles: Timp3
Name: Timp3/Timp3<+> [background:] either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)
Model
Id: MGI:3056101
Synonyms: Not Available
Symbol: Timp3/Timp3 [background:] involves: 129 * C57BL/6 (Mmu)
Genes: Timp3 (Mmu)
Alleles: Timp3
Name: Timp3/Timp3 [background:] involves: 129 * C57BL/6
Model
Id: MGI:4399118
Synonyms: Not Available
Symbol: Timp3/Timp3 [background:] B6.129P2-Timp3 (Mmu)
Genes: Timp3 (Mmu)
Alleles: Timp3
Name: Timp3/Timp3 [background:] B6.129P2-Timp3
cri-2
(Caenorhabditis elegans)Gene
Name: Conserved Regulator of Innate immunity 2
Synonyms: 5I683, CELE_K07C11.5, tag-225, K07C11.5
Source: WB:WBGene00019478
Biotype: protein coding gene
Strict Orthology Symbols: timp3
Timp
(Drosophila melanogaster)Gene
Name: Tissue inhibitor of metalloproteases
Synonyms: dTIMP, tissue inhibitor of metalloproteinases, Dtimp, DTIMP, tissue inhibitor of metalloproteases, TIMP1, timp, TIMP, CG6281
Source: FB:FBgn0025879
Biotype: protein coding gene
Strict Orthology Symbols: timp3
Disease
Source: DOID:0090114
Definition: A hereditary retinal dystrophy that is characterized by loss of central vision as a result of macular disease by the fourth to fifth decade and peripheral visual loss in late life, and that has_material_basis_in autosomal dominant inheritance of heterozygous mutation in the TIMP metallopeptidase inhibitor 3 (TIMP3) gene on chromosome 22q12.
Genes: Timp3 (Mmu)...timp3.S (Xla)...TIMP3 (Hsa)...timp3 (Xtr)...Timp3 (Rno)
Alleles: Timp3
Disease
Source: DOID:2006
Definition: Not Available
Genes: TIMP3 (Hsa)...timp3 (Xtr)...Timp3 (Mmu)...timp3.S (Xla)...Timp3 (Rno)
Gene Ontology
Source: GO:1904684
Synonyms:
- down regulation of metalloendopeptidase activity
- down regulation of metalloendoprotease activity
Branch: biological process
Genes: TIMP3 (Hsa)...Timp3 (Mmu)...Timp3 (Rno)
Source: GO:0051045
Synonyms:
- down regulation of membrane protein ectodomain proteolysis
- down-regulation of membrane protein ectodomain proteolysis
Branch: biological process
Genes: TIMP3 (Hsa)...Timp3 (Rno)...Timp3 (Mmu)
Disease
Source: DOID:3594
Definition: A placenta cancer that has_material_basis_in trophoblastic cells.
Genes: timp3 (Xtr)...timp3.L (Xla)...Timp3 (Mmu)...TIMP3 (Hsa)...Timp3 (Rno)
Gene Ontology
Source: GO:0008191
Synonyms:
- metalloprotease inhibitor
- metalloproteinase inhibitor
Branch: molecular function
Genes: Timp3 (Mmu)...TIMP3 (Hsa)...Timp3 (Rno)
ihb242
(Danio rerio)Allele/Variant
Source: ZFIN:ZDB-ALT-180517-1
Genes: timp3 (Dre)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Genes: timp3 (Dre)
ihb243
(Danio rerio)Allele/Variant
Source: ZFIN:ZDB-ALT-180517-2
Genes: timp3 (Dre)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Genes: timp3 (Dre)
Source: GO:1901706
Synonyms: Not Available
Branch: biological process
Genes: Timp3 (Mmu)...Timp3 (Rno)
Mmp2tm1Ito/Mmp2tm1Ito Timp3tm1Osya/Timp3tm1Osya [background:] involves: 129P2/OlaHsd * C57BL/6
(Mus musculus)Model
Id: MGI:5516118
Synonyms: Not Available
Genes: Timp3 (Mmu)
Alleles: Timp3
Name: Mmp2/Mmp2 Timp3/Timp3 [background:] involves: 129P2/OlaHsd * C57BL
Symbol: Mmp2/Mmp2 Timp3/Timp3 [background:] involves: 129P2/OlaHsd * C57BL
The TIMP3/Apelin axis Regulates Atherosclerosis and Heart Metabolism leading to increased mortality in ApoE null Mice
(Mus musculus)HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:E-GEOD-53548, GEO:GSE53548
Tags: WT vs. mutant, genotype
Summary: The role of TIMP3 in the context of cardiovascular remodeling is relatively unexplored when considering classical risk factors such as hypercholesterolemia, diabetes and hypertension. To learn more the role of TIMP3 in the progression of cardiovascular disease we combined genetics, metabolomics and in vivo phenotypical analysis using the hypercholesterolemic ApoE null mice to generate ApoE-/-Timp3-/- mice, the latter showing increased atherosclerosis, increased mortality and arrhythmias compared to ApoE-/- mice. We have previously described Timp3-/-mice in ( Fiorentino, L., et al., Regulation of TIMP3 in diabetic nephropathy: a role for microRNAs. Acta Diabetol, 2013) . To generate ApoE-/-Timp3-/- knockout animals we crossbred the 2 strains. Offsprings were then backcrossed into ApoE animals for 6 generations to generate a pure lineage. Collectively, metabolite profiles, gene and protein expression consistently suggested a role for TIMP3 to underlie a decreased activation of PPARalpha/AMPK to dampen fatty acids beta-oxidation eventually leading to atherosclerotic plaque composition vulnerability and perturbation of heart metabolism. mRNA profiling in ApoE-/-Timp3-/- mice revealed a TIMP3 effect to regulate Apelin, which we found decreased in the circulation due to its specific downregulation at the myocardial level but not in other well known sites of expression such as the adipose tissue. mRNA sequencing of the heart of ApoE-/-Timp3-/- mice vs ApoE-/- littermates controls.
Symbol: The TIMP3/Apelin axis Regulates Atherosclerosis and Heart Metabolism leading to increased mortality in
Gene Ontology
Source: GO:0031089
Synonyms: Not Available
Branch: cellular component
Genes: TIMP3 (Hsa)
Disease
Source: DOID:14004
Definition: An aortic aneurysm that is located_in the thoracic aorta.
Genes: timp3 (Xtr)...timp3.L (Xla)...Timp3 (Rno)...Timp3 (Mmu)...TIMP3 (Hsa)
Gene Ontology
Source: GO:0051593
Synonyms:
- cellular response to folate
- cellular response to vitamin B9
Branch: biological process
Genes: Timp3 (Rno)
Hsap\TIMP3UAS.Tag:HA
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0336915
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Hsap\TIMP3
Construct Expressed Component: TIMP3 (Hsa)
Gene Ontology
Source: GO:0045861
Synonyms:
- down regulation of proteolysis
- down-regulation of proteolysis
Branch: biological process
Genes: Timp3 (Rno)...Timp3 (Mmu)
Tg(TIMP3-lacZ)7Jeb
(Mus musculus)Allele/Variant
Source: MGI:3056798
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Tg(TIMP3-lacZ)7Jeb
Gene Ontology
Source: GO:0009725
Synonyms:
- growth regulator
- response to hormone stimulus
Branch: biological process
Genes: Timp3 (Rno)...Timp3 (Mmu)...TIMP3 (Hsa)
SYN3
(Homo sapiens)Gene
Name: synapsin III
Synonyms: synapsin 3, synapsin-3, cN28H9.2 (synapsin III)
Source: HGNC:11496
Biotype: protein coding gene
Gene Synopsis: The TIMP3 gene is located within an intron of this gene and is transcribed in the opposite direction.
Source: GO:1904706
Synonyms:
- down regulation of VSMC proliferation
- down regulation of vascular smooth muscle cell proliferation
Branch: biological process
Genes: Timp3 (Rno)...Timp3 (Mmu)
Gene Ontology
Source: GO:1901653
Synonyms: Not Available
Branch: biological process
Genes: Timp3 (Rno)