Version: 8.2.0Date: Wed Aug 27 2025
Category
top-1
(Caenorhabditis elegans)Gene
Name: TOPoisomerase 1
Synonyms: DNA topoisomerase I, CELE_M01E5.5, M01E5.5
Source: WB:WBGene00006595
Biotype: protein coding gene
Symbol: top-1 (Cel)
Symbol: top-1
Gene Synopsis: top-1 encodes the C. elegans DNA topoisomerase I ortholog; TOP-1 exhibits DNA topoisomerase I activity...vitro and in vivo, this activity is required for normal gonad, germline, and embryonic development; top...expressed throughout the gonad and during early embryogenesis, with mRNA levels nearly gone by hatching; TOP...-1 localizes to nuclei, while in later embryos TOP-1 is found in gut nucleoli; during cell division of...1-, 2-, and 4-cell embryos, TOP-1 also localizes to centrosomes.
Cross References: WB:top-1...top-1...top-1
TOP1MT
(Homo sapiens)Gene
Name: DNA topoisomerase I mitochondrial
Synonyms: mitochondrial topoisomerase IB, topoisomerase (DNA) I, mitochondrial, DNA topoisomerase I, mitochondrial, mitochondrial DNA topoisomerase I
Source: HGNC:29787
Biotype: protein coding gene
Strict Orthology Symbols: top-1
TOP1
(Homo sapiens)Gene
Name: DNA topoisomerase I
Synonyms: TOPI, type I DNA topoisomerase, topoisomerase (DNA) I, Scl-70 antigen, DNA topoisomerase 1
Source: HGNC:11986
Biotype: protein coding gene
Strict Orthology Symbols: top-1
Top1
(Mus musculus)Gene
Name: topoisomerase (DNA) I
Synonyms: AI467334, expressed sequence AI467334, D130064I21Rik, Ab2-086, Top-1, RIKEN cDNA D130064I21 gene
Source: MGI:98788
Biotype: protein coding gene
Synonyms: Top-1...Top-1...Top-1
Strict Orthology Symbols: top-1
zgc:173742
(Danio rerio)Gene
Name: zgc:173742
Synonyms: fl27b11, wu:fl27b11, si:dkey-204j6.1
Source: ZFIN:ZDB-GENE-030131-6489
Biotype: protein coding gene
Strict Orthology Symbols: top-1
top1b
(Danio rerio)Gene
Name: DNA topoisomerase Ib
Synonyms: wu:fd15f07, fd15f07, top1
Source: ZFIN:ZDB-GENE-030131-5390
Biotype: protein coding gene
Strict Orthology Symbols: top-1
top1a
(Danio rerio)Gene
Name: DNA topoisomerase Ia
Synonyms: zgc:136349, top1l, wu:fc66a02
Source: ZFIN:ZDB-GENE-060616-217
Biotype: protein coding gene
Strict Orthology Symbols: top-1
Top1
(Rattus norvegicus)Gene
Name: DNA topoisomerase I
Synonyms: Ab2-086, topoisomerase (DNA) I, DNA topoisomerase 1
Source: RGD:621246
Biotype: protein coding gene
Strict Orthology Symbols: top-1
top1mt
(Danio rerio)Gene
Name: DNA topoisomerase I mitochondrial
Synonyms: Not Available
Source: ZFIN:ZDB-GENE-040624-2
Biotype: protein coding gene
Strict Orthology Symbols: top-1
Top1mt
(Rattus norvegicus)Gene
Name: DNA topoisomerase I mitochondrial
Synonyms: topoisomerase (DNA) I, mitochondrial, mitochondrial topoisomerase I, DNA topoisomerase 1, mitochondrial, DNA topoisomerase I, mitochondrial
Source: RGD:1303177
Biotype: protein coding gene
Strict Orthology Symbols: top-1
Top1mt
(Mus musculus)Gene
Name: DNA topoisomerase 1, mitochondrial
Synonyms: RIKEN cDNA 2900052H09 gene, 2900052H09Rik
Source: MGI:1920210
Biotype: protein coding gene
Strict Orthology Symbols: top-1
TOP1
(Saccharomyces cerevisiae)Gene
Name: TOPoisomerase
Synonyms: MAK17, MAK1, YOL006C
Source: SGD:S000005366
Biotype: protein coding gene
Strict Orthology Symbols: top-1
Top1
(Drosophila melanogaster)Gene
Name: Topoisomerase 1
Synonyms: l(1)G0134, topo I, l(1)G0278, l(1)G0201, topi, Topo I, Topo1, l(1)G0229, topoisomerase1, Topoisomerase I, top1, TOPI, dTopoI, TopI, Top 1, ND432, CG6146, topoI, TOP1, TopoI, l(1)top1, topoisomerase I, type I topoisomerase
Source: FB:FBgn0004924
Biotype: protein coding gene
Strict Orthology Symbols: top-1
Synonyms: Top 1
tm2280
(Caenorhabditis elegans)Allele/Variant
Source: WB:WBVar00251189
Genes: top-1 (Cel)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Genes: top-1 (Cel)
top1.2
(Xenopus tropicalis)Gene
Name: DNA topoisomerase I, gene 2
Synonyms: topi, top1.2, DNA topoisomerase I, gene 2, topoisomerase DNA 1
Source: Xenbase:XB-GENE-5814502
Biotype: gene
Strict Orthology Symbols: top-1
top1mt
(Xenopus tropicalis)Gene
Name: DNA topoisomerase I mitochondrial
Synonyms: LOC108719456, top1mt, DNA topoisomerase I mitochondrial
Source: Xenbase:XB-GENE-962427
Biotype: gene
Strict Orthology Symbols: top-1
top1
(Xenopus tropicalis)Gene
Name: DNA topoisomerase I gene 1
Synonyms: DNA topoisomerase I gene 1, top1, topoisomerase DNA 1, top1.1
Source: Xenbase:XB-GENE-950002
Biotype: gene
Strict Orthology Symbols: top-1
Source: GO:0003917
Synonyms:
- DNA topoisomerase I activity
- deoxyribonucleate topoisomerase
Branch: molecular function
Genes: top-1 (Cel)
Gene Ontology
Source: GO:0003916
Synonyms: Not Available
Branch: molecular function
Genes: top-1 (Cel)
Top1tm1Unc
(Mus musculus)Allele/Variant
Source: MGI:2678314
Genes: Top1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Gene Synonyms: Top-1
Gene Ontology
Source: GO:0031616
Synonyms: Not Available
Branch: cellular component
Genes: top-1 (Cel)
Gene Ontology
Source: GO:0006265
Synonyms:
- DNA underwinding
Branch: biological process
Genes: top-1 (Cel)
Top1tm1c(KOMP)Wtsi
(Mus musculus)Allele/Variant
Source: MGI:5805889
Genes: Top1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Gene Synonyms: Top-1
Top1tm1Hon
(Mus musculus)Allele/Variant
Source: MGI:6690606
Genes: Top1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Gene Synonyms: Top-1
Top1tm1b(KOMP)Wtsi
(Mus musculus)Allele/Variant
Source: MGI:5509060
Genes: Top1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Gene Synonyms: Top-1
Top1tm1a(KOMP)Wtsi
(Mus musculus)Allele/Variant
Source: MGI:4362276
Genes: Top1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Gene Synonyms: Top-1
Top1tm1.1Hon
(Mus musculus)Allele/Variant
Source: MGI:6690607
Genes: Top1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Gene Synonyms: Top-1
Top1em2Cya
(Mus musculus)Allele/Variant
Source: MGI:7796773
Genes: Top1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Gene Synonyms: Top-1
Gene Ontology
Source: GO:0007059
Synonyms:
- chromosome division
- chromosome transmission
Branch: biological process
Genes: top-1 (Cel)
Gene Ontology
Source: GO:0006260
Synonyms: Not Available
Branch: biological process
Genes: top-1 (Cel)
Gene Ontology
Source: GO:0016853
Synonyms:
- other isomerase activity
Branch: molecular function
Genes: top-1 (Cel)
Disease
Source: DOID:162
Definition: A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis.
Genes: top-1 (Cel)
Gene Ontology
Source: GO:0005694
Synonyms:
- chromatid
- interphase chromosome
Branch: cellular component
Genes: top-1 (Cel)
(WBcel235)I:13293673G>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003279.8:g.13293673G>A
Genes: top-1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, intron_variant
Diseases: Not Available
Variant Name: (WBcel235)I:13293673G>A
Gene Cross References: top-1
(WBcel235)I:13295047G>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003279.8:g.13295047G>A
Genes: top-1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: synonymous_variant
Diseases: Not Available
Variant Name: (WBcel235)I:13295047G>A
Gene Cross References: top-1
(WBcel235)I:13295297G>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003279.8:g.13295297G>A
Genes: top-1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: (WBcel235)I:13295297G>A
Gene Cross References: top-1
(WBcel235)I:13295308T>C
(Caenorhabditis elegans)Allele/Variant
Source: NC_003279.8:g.13295308T>C
Genes: top-1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: synonymous_variant
Diseases: Not Available
Variant Name: (WBcel235)I:13295308T>C
Gene Cross References: top-1
(WBcel235)I:13296042G>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003279.8:g.13296042G>A
Genes: top-1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)I:13296042G>A
Gene Cross References: top-1
(WBcel235)I:13296092G>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003279.8:g.13296092G>A
Genes: top-1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)I:13296092G>A
Gene Cross References: top-1
(WBcel235)I:13296348T>G
(Caenorhabditis elegans)Allele/Variant
Source: NC_003279.8:g.13296348T>G
Genes: top-1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)I:13296348T>G
Gene Cross References: top-1
(WBcel235)I:13296753T>C
(Caenorhabditis elegans)Allele/Variant
Source: NC_003279.8:g.13296753T>C
Genes: top-1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)I:13296753T>C
Gene Cross References: top-1
(WBcel235)I:13297176G>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003279.8:g.13297176G>A
Genes: top-1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: 3_prime_UTR_variant
Diseases: Not Available
Variant Name: (WBcel235)I:13297176G>A
Gene Cross References: top-1
(WBcel235)I:13293097C>T
(Caenorhabditis elegans)Allele/Variant
Source: NC_003279.8:g.13293097C>T
Genes: top-1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)I:13293097C>T
Gene Cross References: top-1
(WBcel235)I:13295803C>T
(Caenorhabditis elegans)Allele/Variant
Source: NC_003279.8:g.13295803C>T
Genes: top-1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: (WBcel235)I:13295803C>T
Gene Cross References: top-1
(WBcel235)I:13293717T>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003279.8:g.13293717T>A
Genes: top-1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, intron_variant
Diseases: Not Available
Variant Name: (WBcel235)I:13293717T>A
Gene Cross References: top-1
(WBcel235)I:13294468A>G
(Caenorhabditis elegans)Allele/Variant
Source: NC_003279.8:g.13294468A>G
Genes: top-1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: synonymous_variant
Diseases: Not Available
Variant Name: (WBcel235)I:13294468A>G
Gene Cross References: top-1
(WBcel235)I:13295943C>T
(Caenorhabditis elegans)Allele/Variant
Source: NC_003279.8:g.13295943C>T
Genes: top-1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: (WBcel235)I:13295943C>T
Gene Cross References: top-1
(WBcel235)I:13292977G>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003279.8:g.13292977G>A
Genes: top-1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: (WBcel235)I:13292977G>A
Gene Cross References: top-1
(WBcel235)I:13295001G>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003279.8:g.13295001G>A
Genes: top-1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: (WBcel235)I:13295001G>A
Gene Cross References: top-1
(WBcel235)I:13292927A>G
(Caenorhabditis elegans)Allele/Variant
Source: NC_003279.8:g.13292927A>G
Genes: top-1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: (WBcel235)I:13292927A>G
Gene Cross References: top-1