Gene

onecut

Species
Drosophila melanogaster
Symbol
onecut
Name
onecut
Synonyms
  • A1
  • CG1922
Biotype
protein coding gene
Automated Description
Enables DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including ganglia; sense organ; sensory nervous system primordium; sensory neurons; and synaptic neuropil domain. Orthologous to human ONECUT1 (one cut homeobox 1); ONECUT2 (one cut homeobox 2); and ONECUT3 (one cut homeobox 3).
FB Description
onecut (onecut) encodes a transcription factor that binds two different DNA motifs (Cut and Hox). It is mainly expressed in mature neurons and maintains neuronal identity.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR14057
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensONECUT35 of 9YesYes   
Homo sapiensONECUT25 of 9YesYes   
Homo sapiensONECUT15 of 9YesYes   
Mus musculusOnecut25 of 9YesYes   
Mus musculusOnecut35 of 9YesYes   
Mus musculusOnecut15 of 9YesYes   
Rattus norvegicusOnecut15 of 9YesYes   
Rattus norvegicusOnecut25 of 9YesYes   
Xenopus tropicalisonecut16 of 9YesYes   
Xenopus tropicalisonecut1.25 of 9NoYes   
Xenopus tropicalisonecut35 of 9NoYes   
Danio rerioonecut3b6 of 10YesYes  
Danio rerioonecutl6 of 10YesYes  
Danio rerioonecut26 of 10YesYes  
Danio rerioonecut16 of 10YesYes  
Danio rerioonecut3a6 of 10YesYes  
Caenorhabditis elegansceh-487 of 9YesYes   
Caenorhabditis elegansceh-383 of 9NoYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
fertile
lethal | recessive
viable
Showing 1 - 3 of 3 rows
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
R6
Viewer Help
599k600k601k602k603k604k605k606k607k
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
onecutx49
  • onecut[x49]
allele
Yes
onecutG
  • onecut[G]
allele
onecutx122
  • onecut[x122]
allele
Yes
onecutx652
  • onecut[x652]
allele
onecutCR70949-DH.PT-GFSTF.1
  • onecut[CR70949-DH.PT-GFSTF.1]
allele
onecutCR70949-TG4.1
  • onecut[CR70949-TG4.1]
allele
onecutEY30004
  • onecut[EY30004]
allele with one associated variant
insertion
  • intron variant
onecute00113
  • onecut[e00113]
allele with one associated variant
insertion
  • intron variant
Yes
NC_004353.4:g.604158T>Avariant
SNP
  • missense variant
NC_004353.4:g.600898T>Avariant
SNP
  • 3 prime UTR variant
Showing 1 - 10 of 69 rows
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Transgenic Alleles

Species
(carrying the transgene)
Allele symbol
Transgenic construct
Expressed components
Knock-down targets
Regulatory regions
Has Disease Annotations
Has Phenotype Annotations
Drosophila melanogasteronecutEnR.UAS.Tag:HA
  • UASt
Drosophila melanogasteronecutGD4475
  • UASt
Drosophila melanogasteronecutGFP.FPTB
Drosophila melanogasteronecutHMJ22466
  • UAS
Drosophila melanogasteronecutHMS01438
  • UAS
Drosophila melanogasteronecutJF02505
  • UAS
Drosophila melanogasteronecutNIG.1922R
  • UASt
Drosophila melanogasteronecutTOE.GS02600
Drosophila melanogasteronecutUAS.ORF.GW.Tag:HA
  • UASt
Drosophila melanogasteronecutUAS.cNa
  • UASt
Showing 1 - 10 of 12 rows
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Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
599k600k601k602k603k604k605k606k607konecut-RA (onecut)onecut-RB (onecut)

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

7 interactor genes based on 7 annotations
onecut molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
CG31955Drosophila melanogaster
protein
  • two hybrid array
PMID:30995488
protein
drmDrosophila melanogaster
protein
  • two hybrid array
PMID:30995488
protein
egDrosophila melanogaster
protein
  • two hybrid array
PMID:30995488
protein
ftz-f1Drosophila melanogaster
protein
  • two hybrid array
PMID:30995488
protein
me31BDrosophila melanogaster
protein
  • proximity labelling technology
PMID:35020877
protein
PolE4Drosophila melanogaster
protein
  • two hybrid array
PMID:30995488
protein
Ttc1Drosophila melanogaster
protein
  • proximity labelling technology
PMID:35020877
Showing 1 - 7 of 7 rows
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Genetic Interactions

No data available