Gene

Shrm

Species
Drosophila melanogaster
Symbol
Shrm
Name
Shroom
Synonyms
  • CG13942
  • CG13944
Biotype
protein coding gene
Automated Description
Enables actin filament binding activity; kinase binding activity; and protein homodimerization activity. Involved in several processes, including actin cytoskeleton organization; establishment of planar polarity; and protein localization to adherens junction. Located in adherens junction; apical plasma membrane; and cortical actin cytoskeleton. Is expressed in several structures, including anlage in statu nascendi; embryonic/larval midgut primordium; extraembryonic structure; gut section; and head epidermis primordium. Orthologous to several human genes including SHROOM2 (shroom family member 2) and SHROOM3 (shroom family member 3).
FB Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR15012
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensSHROOM26 of 9YesYes   
Homo sapiensSHROOM36 of 9YesYes   
Homo sapiensSHROOM44 of 9NoYes   
Mus musculusShroom25 of 9YesYes   
Mus musculusShroom35 of 9YesYes   
Mus musculusShroom44 of 9NoYes   
Rattus norvegicusShroom35 of 9YesYes   
Rattus norvegicusShroom25 of 9YesYes   
Rattus norvegicusShroom44 of 9NoYes   
Xenopus tropicalisshroom26 of 9YesYes   
Xenopus tropicalisshroom46 of 9YesYes   
Xenopus tropicalisshroom14 of 9NoYes   
Xenopus tropicalisshroom33 of 9NoYes   
Danio rerioshroom2b5 of 10YesYes  
Danio rerioshroom45 of 10YesYes  
Danio rerioshroom34 of 10NoYes  
Danio rerioshroom14 of 10NoYes  
Danio rerioshroom2a3 of 10NoYes  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
R6
Viewer Help
14.310M14.315M14.320M14.325M14.330M14.335M14.340M14.345M14.350M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
ShrmGS0024
  • CG34379[GS0024]
  • CG34379GS0024
allele
ShrmNP2299
  • Shrm[NP2299]
  • Shroom[NP2299]
allele
Shrmunspecified
  • Shrm[unspecified]
  • Shroom[unspecified]
allele
ShrmΔ11
  • Shrm[Delta11]
  • ShrmΔ11
allele
ShrmΔ13.6
  • Shrm[Delta13.6]
  • ShrmΔ13.6
allele
Shrmf04306
  • Shrm[f04306]
  • Shroom[f04306]
allele with one associated variant
insertion
  • 3 prime UTR variant
Shrmf06510
  • Shrm[f06510]
  • Shroom[f06510]
allele with one associated variant
insertion
  • intron variant
ShrmMI11715
  • Shrm[MI11715]
  • Shroom[MI11715]
allele with one associated variant
insertion
  • intron variant
ShrmMI02045-TG4.2
  • Shrm[MI02045-TG4.2]
  • Shroom[MI02045-TG4.2]
allele with one associated variant
insertion
  • intron variant
Shrm5-HA-2530
  • Shrm[5-HA-2530]
  • Shroom[5-HA-2530]
allele with one associated variant
insertion
  • intron variant
Showing 1 - 10 of 1,686 rows
per page

Transgenic Alleles

Species
(carrying the transgene)
Allele symbol
Transgenic construct
Expressed components
Knock-down targets
Regulatory regions
Has Disease Annotations
Has Phenotype Annotations
Drosophila melanogasterShrmA.UAS
  • UASt
Drosophila melanogasterShrmB.UAS
  • UASt
Drosophila melanogasterShrmF-actinBD.UASp.A.Venus
  • UASp
Drosophila melanogasterShrmGD13983
  • UASt
Drosophila melanogasterShrmGD16363
  • UASt
Drosophila melanogasterShrmGD8176
  • UASt
Drosophila melanogasterShrmHD_CFD02183
  • UAS
Drosophila melanogasterShrmHMS02190
  • UAS
Drosophila melanogasterShrmKK106863
  • UASt
Drosophila melanogasterShrmKK108450
  • UASt
Showing 1 - 10 of 18 rows
per page

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
14.310M14.315M14.320M14.325M14.330M14.335M14.340M14.345M14.350MShrm-RD (Shrm)Shrm-RF (Shrm)Shrm-RG (Shrm)Shrm-RH (Shrm)

Sequence Details

Transcript: Mode:
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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

27 interactor genes based on 36 annotations
Shrm molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
CG1598Drosophila melanogaster
protein
  • two hybrid
PMID:14605208
protein
CG3097Drosophila melanogaster
protein
  • two hybrid
PMID:14605208
protein
CG4820Drosophila melanogaster
protein
  • two hybrid
PMID:14605208
protein
CG8206Drosophila melanogaster
protein
  • two hybrid
PMID:14605208
protein
CG17327Drosophila melanogaster
protein
  • two hybrid
PMID:14605208
protein
dupDrosophila melanogaster
protein
  • two hybrid
PMID:14605208
protein
eIF4ADrosophila melanogaster
protein
  • two hybrid
PMID:14605208
protein
kermitDrosophila melanogaster
protein
  • two hybrid
PMID:14605208
protein
krzDrosophila melanogaster
protein
  • two hybrid
PMID:14605208
protein
RokDrosophila melanogaster
protein
  • pull down
PMID:20549743
Showing 1 - 10 of 18 rows
per page

Genetic Interactions

Shrm role
Shrm genetic perturbation
Interactor gene
Interactor species
Interactor role
Interactor genetic perturbation
Interaction type
Phenotype or trait
Source
Reference
suppressed gene
chicDrosophila melanogaster
suppressor gene
genetic suppression
    PMID:33504488
    suppressed gene
    diaDrosophila melanogaster
    suppressor gene
    genetic suppression
      PMID:33504488
      suppressed gene
      Eb1Drosophila melanogaster
      suppressor gene
      genetic suppression
        PMID:33504488
        enhanced gene
        EgfrDrosophila melanogaster
        enhancer gene
        genetic enhancement
          PMID:33504488
          suppressed gene
          enaDrosophila melanogaster
          suppressor gene
          genetic suppression
            PMID:33504488
            enhanced gene
            flwDrosophila melanogaster
            enhancer gene
            genetic enhancement
              PMID:33504488
              suppressed gene
              jarDrosophila melanogaster
              suppressor gene
              genetic suppression
                PMID:33504488
                enhanced gene
                Rap1Drosophila melanogaster
                enhancer gene
                genetic enhancement
                  PMID:33504488
                  suppressed gene
                  RokDrosophila melanogaster
                  suppressor gene
                  genetic suppression
                    PMID:33504488
                    suppressed gene
                    RokDrosophila melanogaster
                    suppressor gene
                    genetic suppression
                      PMID:20549743
                      Showing 1 - 10 of 18 rows
                      per page