Gene

vnd

Species
Drosophila melanogaster
Symbol
vnd
Name
ventral nervous system defective
Synonyms
  • CG6172
  • Dm vnd
Biotype
protein coding gene
Automated Description
Enables DNA-binding transcription factor activity, RNA polymerase II-specific and DNA-binding transcription factor binding activity. Involved in negative regulation of gene expression; nervous system development; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including anlage in statu nascendi; embryonic procephalic segment; gut; gut section; and neuroblasts. Orthologous to human NKX2-2 (NK2 homeobox 2).
FB Description
ventral nervous system defective (vnd) encodes a Nk2-class homeodomain transcription factor that acts in a context-dependent manner as an activator or repressor. It has roles in neuroectoderm patterning, formation and specification of ventral neuroblasts and proper development of their cell lineages.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24340
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensNKX2-24 of 9YesYes   
Mus musculusNkx2-24 of 9YesYes   
Rattus norvegicusNkx2-25 of 9YesYes   
Xenopus tropicalisnkx2-25 of 9YesYes   
Danio rerionkx2.2b5 of 10YesYes  
Danio rerionkx2.2a5 of 10YesYes  
Caenorhabditis elegansceh-223 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
slou162733253 of 8  
scro241745335 of 8  
HGTX363231213 of 8  
NK7.1460132213 of 8  
tin546040283 of 8  
ems654334242 of 8  
bap725339303 of 8  

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abnormal neuroanatomy
abnormal neuroanatomy | embryonic stage
central nervous system
Dd1 neuroblast | embryonic stage 11
Dd1 neuroblast | embryonic stage 9
Dd2 neuroblast | embryonic stage 11
dMP2 neuron
Dv1 neuroblast | embryonic stage 11
Dv2 neuroblast | embryonic stage 11
Dv2 neuroblast | embryonic stage 9
Showing 1 - 10 of 86 rows
per page

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
R6
Viewer Help
584k586k588k590k592k594k596k598k
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
vndD38
  • vnd[D38]
  • vnd[Delta38]
allele
Yes
vnd22
  • l(1)HC218
  • vnd[22]
allele
vnd15
  • l(1)EC6[M15]
  • l(1)EC6M15
allele
vnd18
  • l(1)A131
  • vnd[18]
allele
vnd5
  • vnd[5]
allele
Yes
vnd9
  • l(1)EC6[84]
  • l(1)EC684
allele
vndS1
  • vnd[S1]
allele
Yes
vnd30
  • vnd[30]
allele
vnd12
  • l(1)EC6[116]
  • l(1)EC6116
allele
vnd21
  • l(1)HC143
  • vnd[21]
allele
Showing 1 - 10 of 245 rows
per page

Transgenic Alleles

Species
(carrying the transgene)
Allele symbol
Transgenic construct
Expressed components
Knock-down targets
Regulatory regions
Has Disease Annotations
Has Phenotype Annotations
Drosophila melanogastervnd1-543.G4DBD.Kr
Drosophila melanogastervnd1-543ΔVEH1.G4DBD.Kr
Drosophila melanogastervnd5vnd.hp43.κIg.Tag:HA
Drosophila melanogastervndFRT.Kr
Drosophila melanogastervndGD4406
  • UASt
Drosophila melanogastervndGFP.FPTB
  • vnd (Dme)
  • sfGFP
  • Tag:BLRP
  • Tag:CS(PSP)
  • Tag:CS(TEVp)
  • Tag:FLAG
Drosophila melanogastervndHD_CFD00967
  • UAS
Drosophila melanogastervndHMC03405
  • UAS
Drosophila melanogastervndJF02816
  • UAS
Drosophila melanogastervndKK100622
  • UASt
Showing 1 - 10 of 23 rows
per page

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
584k586k588k590k592k594k596k598kvnd-RA (vnd)vnd-RB (vnd)spdi-RA (spdi)spdi-RB (spdi)spdi-RC (spdi)spdi-RD (spdi)spdi-RE (spdi)spdi-RF (spdi)spdi-RG (spdi)

Sequence Details

Loading...

Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

30 interactor genes based on 35 annotations
vnd molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
abd-ADrosophila melanogaster
protein
  • bimolecular fluorescence complementation
PMID:30247122
protein
Ada2bDrosophila melanogaster
protein
  • anti tag coimmunoprecipitation
PMID:21764853
protein
AlhDrosophila melanogaster
protein
  • two hybrid array
PMID:30995488
protein
ArfGAP1Drosophila melanogaster
protein
  • two hybrid
PMID:14605208
protein
BicCDrosophila melanogaster
protein
  • two hybrid
PMID:14605208
protein
CG7054Drosophila melanogaster
protein
  • two hybrid
PMID:14605208
protein
CG10265Drosophila melanogaster
protein
  • two hybrid
PMID:14605208
protein
CG10654Drosophila melanogaster
protein
  • two hybrid array
PMID:30995488
protein
CG11294Drosophila melanogaster
protein
  • two hybrid array
PMID:30995488
protein
CG31642Drosophila melanogaster
protein
  • two hybrid array
PMID:30995488
Showing 1 - 10 of 35 rows
per page

Genetic Interactions

No data available