Gene

hpl-1

Species
Caenorhabditis elegans
Symbol
hpl-1
Name
HP1 Like (heterochromatin protein) 1
Synonyms
  • CELE_K08H2.6
  • K08H2.6
Biotype
protein coding gene
Automated Description
Enables enzyme binding activity and methylated histone binding activity. Involved in several processes, including negative regulation of Ras protein signal transduction; negative regulation of vulval development; and positive regulation of growth rate. Located in heterochromatin and nucleus. Is expressed widely. Orthologous to several human genes including CBX3 (chromobox 3).
WB Description
hpl-1 encodes one of two C. elegans heterochromatin protein 1 (HP1) homologs; loss of hpl-1 activity alone results in no obvious defects, but animals doubly mutant for hpl-1 and hpl-2 have defects in larval, somatic gonad and germline development; in addition, hpl-1 functions redundantly with hpl-2 and lin-13 in vulval development; rescuing HPL-1::GFP fusion proteins are expressed in nuclei throughout the life cycle, beginning at approximately the 50-cell stage of embryogenesis and continuing through larval and adult stages; expression is observed in most, but not all, cells and is particularly strong in head and tail hypodermal and neuronal nuclei; in nuclei, HPL-1::GFP is seen in foci that do not significantly overlap with those of HPL-2.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR22812
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensCBX38 of 9YesYes   
Homo sapiensCBX57 of 9NoYes   
Homo sapiensCBX17 of 9NoYes   
Mus musculusCbx39 of 9YesYes   
Mus musculusCbx17 of 9NoYes   
Mus musculusCbx57 of 9NoYes   
Rattus norvegicusCbx3l38 of 9YesYes   
Rattus norvegicusCbx38 of 9YesYes   
Rattus norvegicusCbx57 of 9NoYes   
Rattus norvegicusCbx17 of 9NoYes   
Xenopus tropicaliscbx17 of 9YesYes   
Xenopus tropicaliscbx55 of 9YesYes   
Xenopus tropicaliscbx35 of 9YesYes   
Danio reriocbx1a7 of 9YesYes   
Danio reriocbx3a7 of 9YesYes   
Danio reriocbx3b7 of 9YesYes   
Danio reriocbx1b7 of 9YesYes   
Danio reriocbx56 of 9NoYes   
Drosophila melanogasterSu(var)2057 of 9YesYes   
Drosophila melanogasterHP1b7 of 9YesYes   
Drosophila melanogasterHP1c6 of 9NoYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
hpl-2114267483 of 8  
cec-128254334 of 8  
cec-3312040233 of 8  

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
WBcel235
Viewer Help
13.2454M13.2456M13.2458M13.2460M13.2462M13.2464M13.2466M13.2468M13.2470M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
tm1624allele
NC_003284.9:g.13245444C>Tvariant
SNP
  • missense variant
NC_003284.9:g.13245815C>Tvariant
SNP
  • missense variant
NC_003284.9:g.13246363T>Avariant
SNP
  • intron variant
NC_003284.9:g.13245558A>Cvariant
SNP
  • intron variant
NC_003284.9:g.13246339C>Tvariant
SNP
  • intron variant
NC_003284.9:g.13245500G>Avariant
SNP
  • missense variant
NC_003284.9:g.13246540A>Tvariant
SNP
  • intron variant
NC_003284.9:g.13245854T>Avariant
SNP
  • intron variant
NC_003284.9:g.13246702A>Tvariant
SNP
  • intron variant
Showing 1 - 10 of 25 rows
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Transgenic Alleles

No data available

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
PFR60WB
Showing 1 - 1 of 1 rows
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Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
13.2454M13.2456M13.2458M13.2460M13.2462M13.2464M13.2466M13.2468M13.2470MK08H2.6.1 (hpl-1)

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

16 interactor genes based on 21 annotations
hpl-1 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
H25P19.1Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:26476455
protein
hda-1Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:26476455
protein
hda-1Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:34003109
protein
his-24Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:22083954
protein
hmg-11Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:26476455
protein
hpl-2Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:26476455
protein
lim-7Caenorhabditis elegans
protein
  • two hybrid
PMID:14704431
protein
lim-7Caenorhabditis elegans
protein
  • two hybrid
PMID:14704431
protein
lsd-1Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:26476455
protein
mep-1Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:34003109
Showing 1 - 10 of 16 rows
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Genetic Interactions

hpl-1 role
hpl-1 genetic perturbation
Interactor gene
Interactor species
Interactor role
Interactor genetic perturbation
Interaction type
Phenotype or trait
Source
Reference
unspecified role
hpl-2Caenorhabditis elegans
unspecified role
genetic interaction
    PMID:11850401
    unspecified role
    hpl-2Caenorhabditis elegans
    unspecified role
    genetic interaction
      PMID:16905130
      unspecified role
      lin-13Caenorhabditis elegans
      unspecified role
      genetic interaction
        PMID:16905130
        enhancer gene
        lin-35Caenorhabditis elegans
        enhanced gene
        rr33
        genetic enhancement
          PMID:17466069
          suppressor gene
          mat-3Caenorhabditis elegans
          suppressed gene
          genetic suppression
            PMID:17634190
            Showing 1 - 5 of 5 rows
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