Gene

mrp-4

Species
Caenorhabditis elegans
Symbol
mrp-4
Name
Multidrug Resistance Protein family 4
Synonyms
  • CELE_F21G4.2
  • F21G4.2
Biotype
protein coding gene
Automated Description
Predicted to enable ATPase-coupled transmembrane transporter activity. Involved in lipid transport involved in lipid storage and lysosome organization. Located in endocytic vesicle and gut granule. Is expressed in intestine.
WB Description
mrp-4 encodes a putative member of subfamily C of the ATP-binding cassette transporters; MRP-4 is required, redundantly with its paralog WHT-2, for sperm to normally migrate towards a PUFA-based signal exuded by oocytes; hermaphrodites subjected to double wht-2(RNAi) mrp-4(RNAi) are infertile, both through aberrant loss of their own sperm and through failure of males to effectively inseminate them; in mammalian eicosanoid signalling, subfamily C ABC transporters are required for PUFA and eicosanoid transport.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24223
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

No data available

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
GH534WB
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Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
9.8845M9.8850M9.8855M9.8860M9.8865M9.8870M9.8875M9.8880M9.8885M9.8890M9.8895M

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

3 interactor genes based on 5 annotations
mrp-4 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
plk-1Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:35442950
protein
smo-1Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:29348603
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Genetic Interactions

mrp-4 role
mrp-4 genetic perturbation
Interactor gene
Interactor species
Interactor role
Interactor genetic perturbation
Interaction type
Phenotype or trait
Source
Reference
suppressed gene
cup-5Caenorhabditis elegans
suppressor gene
genetic suppression
    PMID:17947407
    suppressor gene
    cup-5Caenorhabditis elegans
    suppressed gene
    genetic suppression
      PMID:18501720
      suppressor gene
      cup-5Caenorhabditis elegans
      suppressed gene
      zu223
      genetic suppression (partial)
        PMID:16943270
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