Gene

th

Species
Xenopus tropicalis
Symbol
th
Name
tyrosine hydroxylase
Synonyms
  • dyt14
  • dyt5b
Biotype
gene
Automated Description
Predicted to enable iron ion binding activity and tyrosine 3-monooxygenase activity. Predicted to act upstream of or within aromatic amino acid metabolic process and dopamine biosynthetic process. Predicted to be located in axon and perinuclear region of cytoplasm. Is expressed in nervous system. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinsonism; heroin dependence; hypertension; and obesity. Orthologous to human TH (tyrosine hydroxylase).
XBXT Description
Cross References
Additional Information
Literature

Orthology

Gene tree
Not Available
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensTH5 of 9YesYes   
Mus musculusTh5 of 9YesYes   
Rattus norvegicusTh5 of 9YesYes   
Xenopus laevisth.L1 of 1YesYes           
Xenopus laevisth.S1 of 1YesYes           
Danio rerioth5 of 9YesYes   
Drosophila melanogasterple5 of 9YesYes   
Caenorhabditis eleganscat-24 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
th214 of 8  

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
Homo sapiensTH
is implicated in
  • onset of
heroin dependence
  • IAGP
    Homo sapiensTH
    is implicated in
    • susceptibility to
    hypertension
    • IAGP
      Homo sapiensTH
      is implicated in
      • resistance to
      obesity
      • IAGP
        Homo sapiensTH
        is marker forParkinson's disease
        • IEP
          Homo sapiensTH
          is implicated inParkinson's disease
          • IMP
            Homo sapiensTH
            is implicated in
            • susceptibility to
            Parkinsonism
            • IAGP
              Homo sapiensTH
              is implicated inParkinsonism
              • IMP
                Rattus norvegicusTh
                is marker forbrain ischemia
                • IEP
                  Rattus norvegicusTh
                  is marker forcongestive heart failure
                  • IEP
                    Rattus norvegicusTh
                    is marker fordepressive disorder
                    • IEP
                      Showing 1 - 10 of 24 rows
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                      Transgenic Alleles

                      No data available

                      Models

                      No data available

                      Sequence Feature Viewer

                      Genome location
                      Assembly version
                      XT9.1
                      Viewer Help
                      12.965M12.970M12.975M12.980M12.985M12.990M12.995M13.000MXM_002938898.4 (th)

                      Sequence Details

                      Transcript: Mode:
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                      Expression

                      Primary Sources
                      Other Sources
                      None
                      Must provide at least one subject
                      Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

                      Molecular Interactions

                      No data available

                      Genetic Interactions

                      No data available