Version: 8.0.0
Date: Tue Jan 28 2025
rap1aa
Danio rerioZFIN:ZDB-GENE-040625-167
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

rap1aa

Species
Danio rerio
Symbol
rap1aa
Name
RAP1A, member of RAS oncogene family a
Synonyms
  • rap1a
  • Rap1b
Biotype
protein coding gene
Automated Description
Enables MAP kinase kinase activity. Acts upstream of or within chondrocyte intercalation involved in growth plate cartilage morphogenesis and heart development. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in brain. Orthologous to human RAP1A (RAP1A, member of RAS oncogene family).
ZFIN Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24070
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensRAP1A7 of 10YesYes☐ ☑☑☑☐☑☑☐☑ ☑
Mus musculusRap1a7 of 10YesYes☐ ☑☑☑☐☑☑☐☑ ☑
Rattus norvegicusRap1a6 of 9YesYes☐ ☑☑☑☐☑☑☐☑  
Xenopus tropicalisrap1a4 of 9YesYes☑ ☐☐☑☑☐☑☐☐  
Drosophila melanogasterRap19 of 10YesYes☑ ☑☑☑☑☑☑☑☑ ☐
Caenorhabditis elegansrap-19 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Saccharomyces cerevisiaeRSR18 of 9YesNo☐ ☑☑☑☑☑☑☑☑  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
rap1ab118599978 of 8☑ ☑☑☑☑☑☑☑ 
rap1b218596948 of 8☑ ☑☑☑☑☑☑☑ 
rap2ab317480636 of 8☑ ☑☐☑☐☑☑☑ 
rap2c417479646 of 8☑ ☑☐☑☐☑☑☑ 
rap2b516683676 of 8☑ ☑☐☑☐☑☑☑ 
kras619173554 of 8☑ ☐☐☑☐☑☑☐ 
zgc:55558718972554 of 8☑ ☐☐☑☐☑☑☐ 
nras818574554 of 8☑ ☐☐☑☐☑☑☐ 
hrasa919071534 of 8☑ ☐☐☑☐☑☑☐ 
hrasb1018670544 of 8☑ ☐☐☑☐☑☑☐ 
rras21118772514 of 8☑ ☐☐☑☐☑☑☐ 
rras1219169504 of 8☑ ☐☐☑☐☑☑☐ 
mrasb1319668493 of 8☑ ☐☐☐☐☑☑☐ 
ralaa1419369483 of 8☑ ☐☐☐☐☑☑☐ 
ralab1519369473 of 8☑ ☐☐☐☐☑☑☐ 
ralba1619469463 of 8☑ ☐☐☐☐☑☑☐ 
mrasa1719665483 of 8☑ ☐☐☐☐☑☑☐ 
rit11817969473 of 8☑ ☐☐☐☐☑☑☐ 
diras1a1919166403 of 8☑ ☐☐☐☐☑☑☐ 
diras1b2017568443 of 8☑ ☐☐☐☐☑☑☐ 
rerg2118360433 of 8☑ ☐☐☐☐☑☑☐ 
rasd42217763413 of 8☑ ☐☐☐☐☑☑☐ 
rhebl12317464413 of 8☑ ☐☐☐☐☑☑☐ 
rasd32420353333 of 8☑ ☐☐☐☐☑☑☐ 
rasl122517059383 of 8☑ ☐☐☐☐☑☑☐ 
rasd12620055352 of 8☑ ☐☐☐☐☐☑☐ 
rem12718459372 of 8☑ ☐☐☐☐☐☑☐ 
gem2820252332 of 8☑ ☐☐☐☐☐☑☐ 
rerglb2919855302 of 8☑ ☐☐☐☐☐☑☐ 
rergla3019949342 of 8☑ ☐☐☐☐☐☑☐ 
rrad3118855322 of 8☑ ☐☐☐☐☐☑☐ 
zgc:1106993217256382 of 8☑ ☐☐☐☐☐☑☐ 
si:dkeyp-59c12.13317954362 of 8☑ ☐☐☐☐☐☑☐ 
rasl11b3420250282 of 8☑ ☐☐☐☐☐☑☐ 
rasl10a3519753272 of 8☑ ☐☐☐☐☐☑☐ 
zgc:640223618254322 of 8☑ ☐☐☐☐☐☑☐ 
zgc:1717043717955322 of 8☑ ☐☐☐☐☐☑☐ 
rasd2b3816859342 of 8☑ ☐☐☐☐☐☑☐ 
nkiras23918848302 of 8☑ ☐☐☐☐☐☑☐ 
rasl11a4017853302 of 8☑ ☐☐☐☐☐☑☐ 
nkiras14117950312 of 8☑ ☐☐☐☐☐☑☐ 
rasd2a4216356332 of 8☑ ☐☐☐☐☐☑☐ 
rem24316348262 of 8☑ ☐☐☐☐☐☑☐ 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
whole organism decreased length, abnormal
whole organism increased curvature, abnormal
Showing 1 - 2 of 2 rows
per page

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
No records match query. Try removing filters.
Showing 0 - 0 of 0 rows
per page

    Alleles and Variants

    No data available
    Download all Alleles/Variants for all genes of the species

    Transgenic Alleles

    No data available

    Models

    Model name
    Experimental condition
    Associated Human Diseases
    Associated Phenotypes
    Modifier
    Source
    pku5Et + MO1-rap1aa + MO2-rap1b + MO4-tp53
    has condition:
    standard conditions
    • heart development disrupted, abnormal
    • heart looping disrupted, abnormal
    		ZFIN
    pku5Et; pku6Tg + MO1-rap1aa + MO2-rap1b + MO4-tp53
    has condition:
    standard conditions
    • cardiac ventricle decreased size, abnormal
    • heart development disrupted, abnormal
    		ZFIN
    TU + MO1-rap1aa + MO2-rap1b + MO4-tp53
    has condition:
    standard conditions
    • cardiac conduction disrupted, abnormal
    • cardiac muscle adherens junction decreased amount, abnormal
    		ZFIN
    WT + MO1-rap1aa
    has condition:
    standard conditions
    • whole organism decreased length, abnormal
    • whole organism increased curvature, abnormal
    		ZFIN
    WT + MO1-rap1aa + MO1-rap1b
    has condition:
    standard conditions
    • MAP kinase kinase activity process quality, abnormal
    • Meckel's cartilage decreased distance ceratohyal cartilage, abnormal
    		ZFIN
    WT + MO1-rap1aa + MO1-rap1b + MO2-raf1a
    has condition:
    standard conditions
    • Meckel's cartilage distance ceratohyal cartilage, normal
    • convergent extension process quality, normal
    		ZFIN
    WT + MO1-rap1aa + MO1-rap1b + MO5-kmt2d
    has condition:
    standard conditions
    • convergent extension disrupted, abnormal
    		ZFIN
    WT + MO1-rap1ab + MO2-rap1aa
    has condition:
    standard conditions
    • whole organism drl expression decreased amount, abnormal
    		ZFIN
    WT + MO2-rap1aaZFIN
    Showing 1 - 9 of 9 rows
    per page

    Sequence Feature Viewer

    Genome location
    Assembly version
    GRCz11
    Viewer Help
    Data currently unavailable; sequence viewer under construction

    Sequence Details

    Loading...

    Expression

    Primary Sources
    Other Sources
    Must provide at least one subject
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    No data available

    Genetic Interactions

    No data available