Species

Danio rerio

Symbol

abcc9

Name

ATP-binding cassette, sub-family C (CFTR/MRP), member 9

Synonyms

si:dkey-183c2.3
SUR2

Biotype

protein coding gene

Automated Description

Enables ATP-activated inward rectifier potassium channel activity. Acts upstream of or within regulation of heart contraction and regulation of potassium:proton exchanging ATPase activity. Predicted to be located in plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in membrane. Is expressed in heart. Used to study hypertrichotic osteochondrodysplasia Cantu type. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1O; familial atrial fibrillation; hypertrichotic osteochondrodysplasia Cantu type; and intellectual disability and myopathy syndrome. Orthologous to human ABCC9 (ATP binding cassette subfamily C member 9).

ZFIN Description

Not Available

Cross References

Additional Information

Literature

Orthology

Gene tree: PANTHER:PTHR24223

Stringency:StringentModerateNo filter

Additional filters to further constrain the results:

Best Score OnlyBest Reverse Score Only

Count:Species:Methods:

Species	Gene symbol	Count	Best	Best reverse	Method Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiens	ABCC9	10 of 10	Yes	Yes	☑ ☑☑☑☑☑☑☑☑ ☑
Mus musculus	Abcc9	10 of 10	Yes	Yes	☑ ☑☑☑☑☑☑☑☑ ☑
Rattus norvegicus	Abcc9	9 of 9	Yes	Yes	☑ ☑☑☑☑☑☑☑☑
Drosophila melanogaster	Sur	3 of 10	Yes	Yes	☑ ☐☑☐☑☐☐☐☐ ☐
Saccharomyces cerevisiae	YBT1	2 of 9	Yes	Yes	☑ ☐☐☐☐☐☐☑☐

Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse

Paralogy

Gene symbol	Rank	Alignment Length (aa)	Similarity %	Identity %	Method Count	Method Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
abcc8	1	1614	78	66	6 of 8	☑ ☑☑☑☐☑☑☐
abcc8b	2	1619	76	63	6 of 8	☑ ☑☑☑☐☑☑☐
abcc1	3	1666	50	32	3 of 8	☑ ☐☐☐☐☑☑☐
abcc10	4	1684	49	30	3 of 8	☑ ☐☐☐☐☑☑☐
abcc2	5	1563	51	32	3 of 8	☑ ☐☐☐☐☑☑☐
abcc3	6	1612	49	30	3 of 8	☑ ☐☐☐☐☑☑☐
abcc6a	7	1575	49	30	3 of 8	☑ ☐☐☐☐☑☑☐
abcc6b.2	8	1525	49	31	2 of 8	☑ ☐☐☐☐☐☑☐
wu:fb13g09	9	1465	49	31	3 of 8	☑ ☐☐☐☐☑☑☐
abcc5	10	1412	50	31	3 of 8	☑ ☐☐☐☐☑☑☐
abcc12	11	1435	49	30	3 of 8	☑ ☐☐☐☐☑☑☐
abcc4	12	1389	51	30	3 of 8	☑ ☐☐☐☐☑☑☐
cftr	13	1571	42	24	3 of 8	☑ ☐☐☐☐☑☑☐
abcc13	14	1386	37	20	3 of 8	☑ ☐☐☐☐☑☑☐

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources

ZFIN

Other Sources

None

Phenotype Term

Annotation details

References

atrium apoptotic process increased occurrence, abnormal

View

PMID:31575858

atrium normal size, normal

View

PMID:31575858

basal communicating artery increased curvature, abnormal

View

PMID:30355756

basal communicating artery kinked, abnormal

View

PMID:30355756

cardiac muscle cell ATP-activated inward rectifier potassium channel activity decreased occurrence, abnormal

View

PMID:31575858

cardiac ventricle apoptotic process increased occurrence, abnormal

View

PMID:31575858

cardiac ventricle increased size, abnormal

View

PMID:31575858

cardiac ventricle malformed, abnormal

View

PMID:31575858

eye decreased diameter, abnormal

View

PMID:38217872

eye decreased distance eye, abnormal

View

PMID:31575858

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Disease Associations

Must provide at least one subject

Cell color indicative of annotation volume

Species	Gene	Association	Disease Qualifier	Disease	Evidence	Source	Based On	References
No records match query. Try removing filters.

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Alleles and Variants

Genome location

Chr4:14660769...14713773 (53.00 kb)

Assembly version

GRCz11

Viewer Help

Data currently unavailable; sequence viewer under construction

Allele/Variant Symbol	Allele Synonyms	Category	Variant
hu11838	Abcc9_ZF.G989E	allele		Yes	Yes
hu11859	Abcc9_ZF.C1043Y	allele			Yes
sa38431		allele with one associated variant	NC_007115.7:g.14710222G>T point mutation stop gained
sa8868		allele with one associated variant	NC_007115.7:g.14676119A>T point mutation stop gained
sa17129		allele with one associated variant	NC_007115.7:g.14691187G>T point mutation stop gained
sa8414		allele with one associated variant	NC_007115.7:g.14676119A>T point mutation stop gained
sa18175		allele with one associated variant	NC_007115.7:g.14676401G>T point mutation splice donor variant
sa26260		allele with one associated variant	NC_007115.7:g.14665331G>A point mutation stop gained

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View detailed Alleles/Variants information

Download all Alleles/Variants for all genes of the species

Transgenic Alleles

No data available

Models

Model name	Experimental condition	Associated Human Diseases	Associated Phenotypes	Source
abcc9^hu11838/+	has condition: standard conditions	hypertrichotic osteochondrodysplasia Cantu type	heart process process quality, abnormal pericardium edematous, abnormal	ZFIN
abcc9^{hu11838/hu11838}	has condition: standard conditions		atrium apoptotic process increased occurrence, abnormal atrium normal size, normal	ZFIN
abcc9^{hu11838/hu11838} (TL)	has condition: chemical treatment by environment pentetrazol		swimming behavior increased process quality, exacerbated	ZFIN
abcc9^{hu11838/hu11838} (TL)	has condition: standard conditions		eye decreased diameter, abnormal eye increased distance eye, abnormal	ZFIN
abcc9^{hu11838/hu11838}; p151Tg/p151Tg	has condition: primary cell culture ventricular myocardium		regulation of potassium:proton exchanging ATPase activity decreased process quality, abnormal	ZFIN
abcc9^{hu11838/hu11838}; p151Tg/p151Tg	has condition: primary cell culture atrial myocardium		regulation of potassium:proton exchanging ATPase activity decreased process quality, abnormal	ZFIN
abcc9^hu11859/+; la116Tg	has condition: standard conditions		basal communicating artery increased curvature, abnormal basal communicating artery kinked, abnormal	ZFIN
abcc9^{hu11859/hu11859}; p151Tg/p151Tg	has condition: primary cell culture ventricular myocardium		regulation of potassium:proton exchanging ATPase activity decreased process quality, abnormal	ZFIN
abcc9^{hu11859/hu11859}; p151Tg/p151Tg	has condition: primary cell culture atrial myocardium		regulation of potassium:proton exchanging ATPase activity decreased process quality, abnormal	ZFIN
abcc9^{hu11859/hu11859}; la116Tg				ZFIN

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Sequence Feature Viewer

Genome location

Chr4:14660769...14713773 (53.00 kb)

Assembly version

GRCz11

Viewer Help

Data currently unavailable; sequence viewer under construction

Sequence Details

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Expression

Primary Sources

Other Sources

Must provide at least one subject

Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

No data available

Genetic Interactions

No data available