Rbl1^tm1Mru

---

Species

Mus musculus

Symbol

Rbl1^tm1Mru

Category

allele

Allele of gene

Rbl1

Transgenic Constructs

None

Synonyms

• p107-

Description

The Rbl1 gene was disrupted by insertion of a PGK neomycin resistance cassette into exon 4 immediately downstream of the sequence encoding amino acid 165. Northern analysis of embryonic fibroblast confluent cultures detected a slightly truncated Rbl1 transcript in homozygous mutant E14.5 embryos. The authors propose that the truncated transcript would be initiated from the PGK promoter. Immunoblot analysis using antisera reactive with the carboxyl-terminal 18 amino acids of RBL1 did not detect protein in homozygous mutant embryos.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations