Version: 8.0.0
Date: Tue Jan 28 2025
Tnftm2Gkl
MGI:2388715
Allele of Tnf
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Tnftm2Gkl

Species
Mus musculus
Symbol
Tnftm2Gkl
Category
allele
Allele of gene
Tnf
Transgenic Constructs
None
Synonyms
  • TNFdeltaARE
Description
69 bp encompassing the AU-rich elements (ARE) were deleted by homologous recombination of a floxed neo cassette and subsequent in vitro cre mediated excision. The resultant allele contained a single loxP site in place of the ARE sequence. ELISA of homozygous mutant mice showed protein levels higher than in wild-type mice, indicating a suppressive role of the AREs.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
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