Allele/Variant

Xisttm2.1Jae

Species
Mus musculus
Symbol
Xisttm2.1Jae
Category
allele
Allele of gene
Xist
Transgenic Constructs
None
Synonyms
  • deltaXist
  • Xist1lox
Description
Exons 1, 2, and 3 as well as 5 kb of the proximal promoter were deleted via cre mediated recombination of single loxP sites in the 5' untranslated region and intron 3. Though complete transcriptional ablation was previously reported by Csankocszki et al., 1999 (J:75502), Turner et al., 2002 (J:80117) reported an endogenous testis-specific transcript that utilizes an upstream promoter in wild-type mice and therefore is putatively present in mutant mice. The deleted region encoded a domain essential for X chromosome inactivation.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

    Association
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