Lta/Tnf^tm1Fda

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Species

Mus musculus

Symbol

Lta/Tnf^tm1Fda

Category

allele

Allele of gene

Tnf

Transgenic Constructs

None

Synonyms

• TNF^-LT^-

Description

The entire Lta gene and the majority of the Tnf gene (to codon 113 in exon 4) were replaced by a neomycin selection cassette inserted by homologous recombination. No transcript or truncated protein was detected by a variety of assays including Northern blot analysis of concanavalin A stimulated splenocytes and ELISA of macrophage colony supernatants. Tnf activity was undetected in LPS stimulated homozygous mutant mice.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations