Allele/Variant

Hprt1tm1(AGT)Sig

Species
Mus musculus
Symbol
Hprt1tm1(AGT)Sig
Category
allele
Allele of gene
Hprt1
Transgenic Constructs
Synonyms
  • hAGTAT
Description
The entire human AGT genomic sequence containing an A to G nucleotide substitution at position -6 of the promoter was inserted into the Hprt locus via homologous recombination. (This polymorphism has been reported in association with hypertension in humans.) RNase protection assay showed transgene expression in liver, kidneys, brain, and aorta. In addition, immunohistochemical analysis and Western blot detected transgene expression in the kidneys and plasma, respectively.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations