Version: 8.0.0
Date: Tue Jan 28 2025
Dnmt3btm5.1Enl
MGI:3047833
Allele of Dnmt3b
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Dnmt3btm5.1Enl

Species
Mus musculus
Symbol
Dnmt3btm5.1Enl
Category
allele
Allele of gene
Dnmt3b
Transgenic Constructs
None
Synonyms
  • Dnmt3b2lox
  • Dnmt3b2loxP
Description
A loxP-flanked PGK-neo cassette was inserted in the intron upstream of exon 19 and a third loxP site in the intron between exons 19 and 20. Cre-mediated recombination deleted the selection cassette in the germline, leaving loxP sites upstream and downstream of exon 19. When mice bearing the present mutation are crossed to Cre recombinase expressing mice, deletion of the floxed DNA segment leads to out-of-frame splicing of the mRNAs encoding all active isoforms of the protein in the tissues where Cre is expressed.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
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