Allele/Variant

Tg(CD3E)26Cpt

Species
Mus musculus
Symbol
Tg(CD3E)26Cpt
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • CD3epsilon
  • CD3epsilontg26
Description
The transgene contains a human gene encoding the CD3 antigen, epsilon polypeptide sequences. 30-35 copies of the transgene integrated into the genome between Sstr5 and Metrn on Chromosome 17, accompanied by duplication of the neighboring genomic region spanning 323 kb. Genes surrounding the integrated tg26 transgene are not disrupted.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
abnormal endometrium morphology
MGI
abnormal placenta labyrinth morphology
MGI
abnormal placenta morphology
MGI
abnormal thymus corticomedullary boundary morphology
MGI
abnormal uterus morphology
MGI
absent endometrial glands
MGI
absent NK cells
MGI
arrested T cell differentiation
MGI
decreased body weight
MGI
decreased double-positive T cell number
MGI
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Disease Associations

No data available