Version: 8.0.0
Date: Tue Jan 28 2025
Tg(Igh-6/Igh-V281)3Jwt
MGI:3056939Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Tg(Igh-6/Igh-V281)3Jwt

Species
Mus musculus
Symbol
Tg(Igh-6/Igh-V281)3Jwt
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • 281HC
  • H125.gl
Description
The construct for Tg(Igh-6/Igh-V281)3Jwt has a germ line reversion encoding D at residue 49 (from G)and another encoding V (from E) at residue 56. The transgene encodes an IgMa constant region with a variable region nearly identical to that of the BALB/c IgG1 mouse anti-human insulin monoclonal antibody, mAb125, (from the American Type Culture Collection) but lacking the high affinity specificity for insulin.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
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