Allele/Variant

1700016L21RikTg(Itgax-HBEGF/EGFP)57Lan

Species
Mus musculus
Symbol
1700016L21RikTg(Itgax-HBEGF/EGFP)57Lan
Category
allele
Allele of gene
1700016L21Rik
Transgenic Constructs
Synonyms
  • 1700016L21RikTg(Itgax-DTR/EGFP)57Lan
  • CD11c-DTR
Description
The transgene contains a fusion product involving simian diphtheria toxin receptor and green fluorescent protein under the control of the mouse Itgax promoter (CD11c). Two lines were created (line 11 and line 57) with 1 to 2 copies and 20 copies of the transgene, respectively. All CD8+ and CD8- dendritic cells in the spleen fluoresce and are DT sensitive. Immunohistochemical and flow cytometric analyses show that expression of the transgene is specific to splenic dendritic cells. Line 57 inserted into the gene at 80448681-80455738 (Build GRCm38/mm10) resulting in a 7057 bp deletion. Founder line 57 has a copy number of greater than 20.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
  • HBEGF
Knock-down Targets
None
Regulatory Regions
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations