Version: 8.0.0Date: Tue Jan 28 2025
Allele/Variant
Tg(Igh-VB1-8/Igh-6m)1Mjsk
- Species
- Mus musculus
- Symbol
- Tg(Igh-VB1-8/Igh-6m)1Mjsk
- Category
- allele
- Allele of gene
- None
- Transgenic Constructs
- Synonyms
- mIg
- Tg(Igh-VB1-8/Igh-6)1Mjsk
- Description
- The transgene encodes a membrane-bound, but not a secreted, immunoglobulin mu heavy chain. The variable region of the transgene comprises the VDJ moiety from the functionally rearranged Igh gene of the C57BL/6-derived B1-8 hybridoma, containing the V-region segment Vh186.2 and recognizing the hapten (4-hydroxy-3-nitrophenyl)acetyl. This is followed by a J-C intron fragment containing the Igh intronic enhancer and an Igh-6 constant region gene (of haplotype a) from which the exon encoding the secreted form of Igmu and its associated polyadenylation signal have been deleted.
- Additional Information
- Literature
Transgenic Constructs
This allele contains 1 transgenic construct- Symbol
- Expressed Components
- Knock-down Targets
- None
- Regulatory Regions
- None