Allele/Variant

Atg7tm1Tchi

Species
Mus musculus
Symbol
Atg7tm1Tchi
Category
allele
Allele of gene
Atg7
Transgenic Constructs
None
Synonyms
  • Atg7F
  • Atg7Flox
Description
A targeting construct was designed to insert a loxP site in intron of the 13th coding exon. Coding exon 14 was fused to a cDNA encoding coding exons 15, 16, and 17 together with a polyadenylation signal after the stop codon. This was then followed by a neomycin resistance cassette and a second loxP site. An additional exon 14 sequence with a stop codon preceding the active site cysteine codon was inserted after the second loxP site. Immunoblot showed that the presence of the loxP sites and neo did not interefere with translation.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations