Gene

Atg7

Species
Mus musculus
Symbol
Atg7
Name
autophagy related 7
Synonyms
  • 1810013K23Rik
  • Apg7l
Biotype
protein coding gene
Automated Description
Enables Atg12 activating enzyme activity and Atg8 activating enzyme activity. Involved in several processes, including macroautophagy; regulation of circadian rhythm; and synaptic vesicle cycle. Acts upstream of with a positive effect on chromatin organization. Acts upstream of or within several processes, including central nervous system development; defense response to symbiont; and regulation of primary metabolic process. Located in axoneme and perinuclear region of cytoplasm. Is active in dopaminergic synapse. Is expressed in central nervous system; heart; lower jaw molar; and retina. Used to study Parkinson's disease; myelodysplastic syndrome; and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 31. Orthologous to human ATG7 (autophagy related 7).
MGI Description
PHENOTYPE: Mutation of this gene causes impairment of constitutive and starvation-induced autophagy resulting in defective protein degradation. Homozygous null mice die within 1 day of birth and have decreased body weight. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10953
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensATG710 of 10YesYes  
Rattus norvegicusAtg79 of 9YesYes   
Danio rerioatg710 of 10YesYes  
Drosophila melanogasterAtg79 of 9YesYes   
Caenorhabditis elegansatg-79 of 9YesYes   
Saccharomyces cerevisiaeATG79 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Uba1162833182 of 9 
Uba6256032202 of 9 
Uba1y356531192 of 9 
Mocs3436036233 of 9 
Uba3536335222 of 9 
Uba2634534212 of 9 
Uba7731536242 of 9 
Uba5828638222 of 9 
Sae1918739232 of 9 
Nae11019736212 of 9 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abnormal acrosome assembly
abnormal acrosome morphology
abnormal amino acid level
abnormal autophagosome formation
abnormal autophagy
abnormal brain morphology
abnormal cauda epididymis morphology
abnormal circulating amino acid level
abnormal circulating chemokine level
abnormal circulating enzyme level
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

No mapped variant information available
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
Atg7em1Gpt
  • Atg7em1Cflox
allele
Atg7em1(IMPC)Ccpczallele
Yes
Atg7em1Lutzy
  • Atg7 cKO
allele
Atg7tm1Tchi
  • Atg7F
  • ATG7flox
allele
YesYes
Atg7tm1.1Tchi
  • Atg7-
allele
Yes
NC_000072.7:g.114633693A>Tvariant
SNP
  • intron variant
NC_000072.7:g.114633760A>Gvariant
SNP
  • intron variant
NC_000072.7:g.114633858T>Cvariant
SNP
  • intron variant
NC_000072.7:g.114639265G>Tvariant
SNP
  • intron variant
NC_000072.7:g.114625460C>Tvariant
SNP
  • intron variant
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Transgenic Alleles

No data available

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
Atg7tm1Tchi/Atg7tm1Tchi Commd10Tg(Vav1-icre)A2Kio/Commd10+ [background:] involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj
  • abnormal common lymphocyte progenitor cell morphology
  • abnormal hematopoietic stem cell morphology
MGI
Atg7tm1Tchi/Atg7tm1Tchi En1tm2(cre)Wrst/En1+ [background:] involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj
  • Purkinje cell degeneration
  • abnormal brain morphology
MGI
Atg7tm1Tchi/Atg7tm1Tchi Lyz2tm1(cre)Ifo/Lyz2+ [background:] involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj
  • abnormal circulating chemokine level
  • abnormal kidney morphology
MGI
Atg7tm1Tchi/Atg7tm1Tchi Slc6a3tm1(cre)Xz/Slc6a3+ [background:] involves: 129S1/Sv * C57BL/6NCrlj * CBA/JNCrlj
  • abnormal neuron morphology
  • abnormal substantia nigra pars compacta morphology
MGI
Alpltm1(cre)Nagy/Alpl+ Atg7tm1Tchi/Atg7tm1Tchi [background:] involves: 129 * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj
  • abnormal acrosome assembly
  • abnormal acrosome morphology
MGI
Apctm2.1Cip/Apc+ Atg7tm1Tchi/Atg7tm1Tchi Tg(Vil1-cre/ERT2)23Syr/0 [background:] involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * DBA/2
  • abnormal Paneth cell morphology
  • abnormal gut flora balance
MGI
Atg7em1(IMPC)Ccpcz/Atg7+ [background:] C57BL/6N-Atg7em1(IMPC)Ccpcz/Ccpcz
  • abnormal heart morphology
  • abnormal mammary gland morphology
MGI
Atg7em1(IMPC)Ccpcz/Atg7em1(IMPC)Ccpcz [background:] C57BL/6N-Atg7em1(IMPC)Ccpcz/Ccpcz
  • abnormal embryo size
  • no spontaneous movement
MGI
Atg7tm1.1Tchi/Atg7tm1.1Tchi [background:] involves: C57BL/6 * CBA * FVB/N
  • abnormal circulating amino acid level
  • abnormal intracellular organelle morphology
MGI
Atg7tm1Tchi/Atg7tm1Tchi Aviltm2(cre)Fawa/Avil+ [background:] involves: 129P2/OlaHsd * C57BL/6 * CBA
  • abnormal sensory neuron morphology
  • bradykinesia
MGI
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Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
114.64M114.66M114.68M114.70M114.72M114.74M114.76M114.78M114.80M114.82M

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

36 interactor genes based on 47 annotations
Atg7 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
Atg3Mus musculus
protein
  • affinity chromatography technology
PMID:22170151
protein
Atg3Mus musculus
protein
  • pull down
PMID:22055190
protein
Atg3Mus musculus
protein
  • affinity chromatography technology
PMID:22170151
protein
Atg3Mus musculus
protein
  • affinity chromatography technology
PMID:24191030
protein
Atg3Mus musculus
protein
  • biochemical
PMID:32325033
protein
Atg5Mus musculus
protein
  • biochemical
PMID:32325033
protein
Atg5Mus musculus
protein
  • affinity chromatography technology
PMID:35449600
protein
Atg7Mus musculus
protein
  • affinity chromatography technology
PMID:22170151
protein
Atg7Mus musculus
protein
  • pull down
PMID:22055190
protein
Atg12Mus musculus
protein
  • affinity chromatography technology
PMID:11890701
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Genetic Interactions

Atg7 role
Atg7 genetic perturbation
Interactor gene
Interactor species
Interactor role
Interactor genetic perturbation
Interaction type
Phenotype or trait
Source
Reference
unspecified role
Atg12Mus musculus
unspecified role
positive genetic interaction (sensu BioGRID)
  • increased cell proliferation
PMID:32968282
unspecified role
Fitm2Mus musculus
unspecified role
positive genetic interaction (sensu BioGRID)
  • increased cell proliferation
PMID:32968282
enhancer gene
Keap1Mus musculus
enhanced gene
phenotypic enhancement (sensu BioGRID)
  • abnormal liver morphology, abnormal liver morphology
PMID:20173742
suppressor gene
Nfe2l2Mus musculus
suppressed gene
phenotypic suppression (sensu BioGRID)
  • abnormal liver morphology, abnormal liver morphology
PMID:20173742
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