Allele/Variant

Tg(Ckm-LPL)HRze

Species
Mus musculus
Symbol
Tg(Ckm-LPL)HRze
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • MCK-H
Description
This transgene consists of an LPL minigene containing the full-length human LPL cDNA including the 5' untranslated sequence, the complete coding region, the 3' untranslated sequence, and 339 bp of 3' flanking region under the control of the mouse muscle creatine kinase promoter. This line integrated an estimated number of 20 copies per genome and is the high expression line. Human LPL is expressed in skeletal and cardiac muscle but not other tissues and there is a 24.4-fold increase in heparin releasable LPL activity in skeletal muscle.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
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