Allele/Variant

Gabrg2tm1Spet

Species
Mus musculus
Symbol
Gabrg2tm1Spet
Category
allele
Allele of gene
Gabrg2
Transgenic Constructs
None
Synonyms
  • Gabrg2R43Q
  • Gabrg2tmSpet
Description
The coding region was replaced with a coding region containing substitution that results in an amino acid substution of a glutamine for an arginine at position 43 (R43Q), 4 aditional silent mutations (not identified) and a floxed neo cassette that was subsequently removed by cre-mediated recombination. Expression levels were confirmed to be normal by RT-PCR analysis on total brain extracts. Reduction in protein product was confirmed by wesrtern blot analysis on extracts from E16 forebrains. This allele was generated from Gabrg2tm2Spet.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations