Allele/Variant

Tg(Tnf)6074Gkl

Species
Mus musculus
Symbol
Tg(Tnf)6074Gkl
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • Tg6074
Description
These mice express a construct which contains the promoter and entire coding region of the murine TNF-alpha gene. A 0.77-kb EcoRI-Pst I/Sal I fragment, containing the 3'-untranslated region and polyadenylylation site of the human beta-globin gene was ligated to the 3' end of the murine gene. The transgene is expressed specifically in neuron cell bodies of the CNS and is detected in all areas tested including the cerebral cortex, cerebellum, diencephalon, brain stem, and spinal cord. Expression is not detected in astrocyte cultures, activated peritoneal macrophages or activated splenocytes. Expression is first detectable at low levels in P6 mice and increases greatly in intensity until P15 after which expression remains at high levels.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
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