Allele/Variant

Chrna4tm2.1Dra

Species
Mus musculus
Symbol
Chrna4tm2.1Dra
Category
allele
Allele of gene
Chrna4
Transgenic Constructs
None
Synonyms
  • S248F
Description
In vivo Cre-mediated recombination removed the floxed neo cassette leaving just the S248F (TCG to TTT) in exon 5 in the putative M2 region. This mutation had little effect on nicotinic acetylcholine receptor ligand binding; however, dopamine release mediated by receptor complexes containing the mutated subunit was decreased at high agonist concentrations.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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Disease Associations

No data available