Version: 8.0.0
Date: Tue Jan 28 2025
Tg(Camk2a-AIDPak)21Stl
MGI:4836192Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Tg(Camk2a-AIDPak)21Stl

Species
Mus musculus
Symbol
Tg(Camk2a-AIDPak)21Stl
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • dnPAK
Description
The dnPAK transgene was designed with the mouse autoinhibitory domain (AID) of the p21 protein (Cdc42/Rac)-activated kinase 3 (Pak3) gene tagged with myc and driven by a mouse calcium/calmodulin-dependent protein kinase II alpha (Camk2a) promoter, followed by a simian virus 40 (SV40) polyadenylation site. This domain is conserved in all three Pak genes (Pak1, Pak2, Pak3). Lines 21 and 110 were generated.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
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