Gene

Pak3

Species
Mus musculus
Symbol
Pak3
Name
p21 (RAC1) activated kinase 3
Synonyms
  • beta-PAK
  • PAK-3
Biotype
protein coding gene
Automated Description
Enables protein kinase activity and small GTPase binding activity. Involved in axonogenesis; dendritic spine morphogenesis; and regulation of postsynapse organization. Acts upstream of or within cellular response to organic cyclic compound and dendritic spine development. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including central nervous system; gonad; liver; lung; and retina. Used to study non-syndromic X-linked intellectual disability 30. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 30. Orthologous to human PAK3 (p21 (RAC1) activated kinase 3).
MGI Description
PHENOTYPE: Mice homozygous for one knock-out allele display a selective impairment in hippocampal late-phase long-term potentiation, and deficits in learning and memory. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR48015
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Pak1159682748 of 9 
Pak2258580707 of 9 
Pak5371245304 of 9 
Pak6469145304 of 9 
Pak4562249354 of 9 
Map3k1661342252 of 9 
Map3k19760841262 of 9 
Map3k14858438242 of 9 
Stk4930962423 of 9 
Stk31029963423 of 9 
Taok11132655403 of 9 
Taok31230756393 of 9 
Taok21330756383 of 9 
Stk261427565462 of 9 
Slk1530957402 of 9 
Stk241627265462 of 9 
Stk251727265462 of 9 
Stk391836348342 of 9 
Tnik1929257393 of 9 
Mink12029257393 of 9 
Stk102132155372 of 9 
Map4k32228561422 of 9 
Nrk2335050322 of 9 
Map4k22428560412 of 9 
Oxsr12530155402 of 9 
Map3k82642042262 of 9 
Map4k12730555372 of 9 
Map4k52826361422 of 9 
Stradb2941040252 of 9 
Map4k43027557392 of 9 
Strada3137044272 of 9 
Nek43226349282 of 9 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abnormal conditioned taste aversion behavior
abnormal dendritic spine morphology
abnormal dentate gyrus neuron dendrite morphology
abnormal learning/memory/conditioning
abnormal long-term spatial reference memory
abnormal miniature excitatory postsynaptic currents
abnormal neuron differentiation
abnormal neuron physiology
abnormal synapse morphology
abnormal synaptic vesicle number
Showing 1 - 10 of 14 rows
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
142.35M142.40M142.45M142.50M142.55M

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

19 interactor genes based on 23 annotations
Pak3 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
Arhgap1Mus musculus
protein
  • biochemical
PMID:32325033
protein
Arhgap18Mus musculus
protein
  • biochemical
PMID:32325033
protein
Arhgef7Mus musculus
protein
  • affinity chromatography technology
PMID:9726964
protein
Arhgef7Mus musculus
protein
  • biochemical
PMID:32325033
protein
CDC42Homo sapiens
protein
  • filter binding
PMID:7493928
protein
CDC42Homo sapiens
protein
  • solid phase assay
PMID:23022564
protein
CDC42Homo sapiens
protein
  • pull down
PMID:14505571
protein
CDC42Homo sapiens
protein
  • pull down
PMID:23022564
protein
Cdc42Mus musculus
protein
  • biochemical
PMID:32325033
protein
Cntnap2Mus musculus
protein
  • proximity labelling technology
PMID:36417873
Showing 1 - 10 of 23 rows
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Genetic Interactions

No data available