Allele/Variant

Cdh5tm4(Cdh5/Fkbp,Ptprb/Mtor*)Dvst

Species
Mus musculus
Symbol
Cdh5tm4(Cdh5/Fkbp,Ptprb/Mtor*)Dvst
Category
allele
Allele of gene
Cdh5
Transgenic Constructs
Synonyms
  • VE-cadherin FKBP/VE-PTP FRB*
Description
A floxed cassette containing the rapamycin binding domain of the FK 506 binding protein fused to the C terminus of Cdh5, an IRES, a mutated form of the rapamycin binding domain of mammalian target of rapamycin (FRB*), containing an HA-tag at its C terminus, fused to the C terminus of Ptprb, and an FRT flanked hygromycin gene was inserted via recombinase mediated cassette exchange using Cdh5tm1Dvst. In lungs from homozygous mice wild-type protein is not expressed and expression of the mutant Cdh5/Fkbp protein is detected at levels similar to wild-type protein in control mice. Expression of the mutant Ptprb/Mtor* protein is about 30% of the level of expression of the endogenous protein in lungs from homozygous mice. Dissociation of heterodimers of the two mutant proteins is impaired in the presence of rapalog.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations