Version: 8.0.0
Date: Tue Jan 28 2025
Tg(ACTA1-STIM1)2Jmol
MGI:5550399Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Tg(ACTA1-STIM1)2Jmol

Species
Mus musculus
Symbol
Tg(ACTA1-STIM1)2Jmol
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
None
Description
The human STIM1 cDNA encoding the shorter spliced form was cloned into a human ACTA1 promoter (modified with a troponin 1 element to enhance expression in slow fibers) to create a skeletal muscle-specific transgenic strain. Expression is increased approximately 6-fold in the quadriceps, and at uniformly high levels in a broad range of skeletal muscle groups. No expression is observed in the heart. The transgene is integrated on the Y chromosome in this "low expressor" line.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
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