Allele/Variant

Or8a1tm39(Gnas*)Mom

Species
Mus musculus
Symbol
Or8a1tm39(Gnas*)Mom
Category
allele
Allele of gene
Or8a1
Transgenic Constructs
Synonyms
  • M71(RDY)-caGs-GFP
Description
Two amino acid substitutions (D121R;R122D) were made to change the highly conserved DRY motif to RDY to diminish G-protein signalling, and an internal ribosome entry site followed by a constitutively active Gnas coding sequence (due to a Q227L sequence change) was inserted just downstream of the endogenous coding sequence to give bicistronic expression.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations