Allele/Variant

Tg(Vav1-STAT5B*N642H)726Biat

Species
Mus musculus
Symbol
Tg(Vav1-STAT5B*N642H)726Biat
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • Tg(STAT5BN/H)726Biat
Description
The human STAT5B harboring the N642H mutation in the SH2 domain is under the control of the hematopoietic specific Vav1 promoter. This is a gain-of-function mutation in leukemic patients that causes enhanced and prolonged tyrosine phosphorylation.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations