Cdk1^tm3.1Kald

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Species

Mus musculus

Symbol

Cdk1^tm3.1Kald

Category

allele

Allele of gene

Cdk1

Transgenic Constructs

None

Synonyms

• Cdk1^AF

Description

A splice acceptor-STOP/neomycin selection cassette flanked by loxP sites was introduced on the 5 end of exon 3, which was modified to introduce point mutations that generate a threonine to alanine substitution at amino acid 14 (T14A) and a tyrosine to phenylalanine substitution at amino acid 15 (Y15F). A14 and F15 cannot be phosphorylated and thus this mutant becomes non-inhibitable by phosphorylation. Cre-mediated recombination removes the loxP-flanked STOP cassette.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations