Allele/Variant

Klhl17em1Yph

Species
Mus musculus
Symbol
Klhl17em1Yph
Category
allele
Allele of gene
Klhl17
Transgenic Constructs
None
Synonyms
None
Description
CRISPR/Cas9 technology using gRNAs 5'-CTAACCTAGGCGCCACACGA (targeting the promoter region) and 5'-TAGACGTTGGAGTTCTATGG (targeting the region after exon 12) deleted the entire gene (exons 1 to 12). Western blot analysis confirmed absence of protein in homozygous neurons.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
abnormal dendritic spine morphologyMGI
abnormal response to social novelty
MGI
increased locomotor activity
MGI
increased miniature excitatory postsynaptic current amplitude
MGI
increased vertical activity
MGI
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Disease Associations

No data available