Allele/Variant

Ptentm1.1Yxy

Species
Mus musculus
Symbol
Ptentm1.1Yxy
Category
allele
Allele of gene
Pten
Transgenic Constructs
None
Synonyms
  • ptenalpham
  • ptenalphamu
Description
Leucine codons 1 and 6 (CTG) in the alpha isoform (which is translated from an alternative CTG initiation codon 173 codons upstream of the canonical ATG codon) were replaced with glycine codons GGA (p.L1G, p.L6G). The loxP site flanked neomycin resistance gene cassette that was inserted into intron 1 was removed through subsequent cre-mediated recombination. Western blot experiments confirmed the absence of alpha isoform peptide expression from this allele in the brain, while canonical isoform expression was unaffected.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations