Version: 8.0.0
Date: Tue Jan 28 2025
Ace2em2(ACE2)Mlkn
MGI:7507528
Allele of Ace2
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Ace2em2(ACE2)Mlkn

Species
Mus musculus
Symbol
Ace2em2(ACE2)Mlkn
Category
allele
Allele of gene
Ace2
Transgenic Constructs
Synonyms
  • hACE2hypo
Description
The coding sequence of the first translated exon of the mouse gene (exon 2) was replaced by an expression cassette containing a loxP site, a modified human ACE2 cDNA, loxP site, woodchuck hepatitis virus posttranscriptional regulatory element (WPRE), SV40 polyA signal, and FRT-flanked PGK-neomycin resistance gene via CRISPR/Cas9 technology. The human ACE2 cDNA was modified to use the mouse Ace2 signal peptide and codon-optimized for a mouseThe first loxP site interrupts the 5’ untranslated sequence of the mouse Ace2.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
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