Gene

Pfrx

Species
Drosophila melanogaster
Symbol
Pfrx
Name
6-phosphofructo-2-kinase
Synonyms
  • CG3400
  • fi-phosphofructo-2-kinase
Biotype
protein coding gene
Automated Description
Predicted to enable 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. Predicted to be involved in carbohydrate phosphorylation; fructose 2,6-bisphosphate metabolic process; and positive regulation of glycolytic process through fructose-6-phosphate. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including adult head; anlage in statu nascendi; antennal anlage; cuboidal/columnar epithelium; and embryonic/larval midgut primordium. Orthologous to several human genes including PFKFB2 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2) and PFKFB4 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4).
FB Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10606
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensPFKFB28 of 9YesYes   
Homo sapiensPFKFB48 of 9YesYes   
Homo sapiensPFKFB37 of 9NoYes   
Homo sapiensPFKFB17 of 9NoYes   
Mus musculusPfkfb48 of 9YesYes   
Mus musculusPfkfb28 of 9YesYes   
Mus musculusPfkfb18 of 9YesYes   
Mus musculusPfkfb37 of 9NoYes   
Rattus norvegicusPfkfb28 of 9YesYes   
Rattus norvegicusPfkfb18 of 9YesYes   
Rattus norvegicusPfkfb48 of 9YesYes   
Rattus norvegicusPfkfb38 of 9YesYes   
Xenopus tropicalispfkfb18 of 9YesYes   
Xenopus tropicalispfkfb24 of 9NoYes   
Xenopus tropicalispfkfb44 of 9NoYes   
Xenopus tropicalispfkfb33 of 9NoYes   
Danio reriopfkfb18 of 10YesYes  
Danio reriopfkfb2b8 of 10YesYes  
Danio reriopfkfb4b8 of 10YesYes  
Danio reriosi:dkey-96f10.18 of 10YesYes  
Danio reriopfkfb4a8 of 10YesYes  
Danio reriopfkfb37 of 10NoYes  
Danio reriopfkfb2a7 of 10NoYes  
Caenorhabditis eleganspfkb-1.28 of 9YesYes   
Caenorhabditis eleganspfkb-1.18 of 9YesYes   
Saccharomyces cerevisiaeFBP268 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abnormal sleep
chemical resistant
viable
Showing 1 - 3 of 3 rows
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
R6
Viewer Help
19.496M19.498M19.500M19.502M19.504M19.506M19.508M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
PfrxGT16-8
  • 6-phosphofructo-2-kinase[GT16-8]
  • 6-phosphofructo-2-kinaseGT16-8
allele
Yes
PfrxCR71287-KO-TG4.1
  • Pfrx[CR71287-KO-TG4.1]
allele
PfrxGG01015
  • Pfrx[GG01015]
allele
PfrxBG02003
  • Pfrx[BG02003]
allele
Yes
PfrxGS7393
  • Pfrx[GS7393]
allele
PfrxGG01837
  • Pfrx[GG01837]
allele
PfrxGG01007
  • Pfrx[GG01007]
allele
PfrxGG01408
  • Pfrx[GG01408]
allele
PfrxNP2141
  • Pfrx[NP2141]
allele
PfrxNP7284
  • Pfrx[NP7284]
allele
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Transgenic Alleles

Species
(carrying the transgene)
Allele symbol
Transgenic construct
Expressed components
Knock-down targets
Regulatory regions
Has Disease Annotations
Has Phenotype Annotations
Drosophila melanogasterPfrxGD10485
  • UASt
Drosophila melanogasterPfrxGL00295
  • UAS
Drosophila melanogasterPfrxHD_CFD02366
  • UAS
Drosophila melanogasterPfrxHMC04605
  • UAS
Drosophila melanogasterPfrxUAS.Tag:FLAG,Tag:HA
  • UASt
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Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
19.496M19.498M19.500M19.502M19.504M19.506M19.508MPfrx-RA (Pfrx)Pfrx-RB (Pfrx)Pfrx-RD (Pfrx)Pfrx-RE (Pfrx)Pfrx-RF (Pfrx)Pfrx-RG (Pfrx)Pfrx-RH (Pfrx)Pfrx-RI (Pfrx)Pfrx-RJ (Pfrx)Pfrx-RK (Pfrx)Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.

Sequence Details

Transcript: Mode:

Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

6 interactor genes based on 6 annotations
Pfrx molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
CG3517Drosophila melanogaster
protein
  • two hybrid
PMID:14605208
protein
CG31441Drosophila melanogaster
protein
  • anti tag coimmunoprecipitation
PMID:38944040
protein
Dlc90FDrosophila melanogaster
protein
  • two hybrid
PMID:14605208
protein
LeashDrosophila melanogaster
protein
  • affinity chromatography technology
PMID:38270169
protein
lolaDrosophila melanogaster
protein
  • two hybrid
PMID:14605208
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Genetic Interactions

Pfrx role
Pfrx genetic perturbation
Interactor gene
Interactor species
Interactor role
Interactor genetic perturbation
Interaction type
Phenotype or trait
Source
Reference
suppressor gene
pblDrosophila melanogaster
suppressed gene
genetic suppression
    PMID:18690061
    Showing 1 - 1 of 1 rows
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