Gene

Nup50

Species
Drosophila melanogaster
Symbol
Nup50
Name
Nucleoporin 50kD
Synonyms
  • CG2158
  • Nuclear pore protein 50
Biotype
protein coding gene
Automated Description
Enables chromatin DNA binding activity. Involved in heat shock-mediated polytene chromosome puffing; positive regulation of transcription by RNA polymerase II; and protein import into nucleus. Located in chromatin and polytene chromosome band. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; head epidermis primordium; somatic trunk mesoderm derivative; and trunk visceral muscle primordium. Used to study neurodegenerative disease. Orthologous to human NUP50 (nucleoporin 50).
FB Description
Nucleoporin 50kD (Nup50) encodes an important protein for TGF-beta signal transduction by mediating the nuclear translocation of the product of Mad.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23138
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensNUP509 of 9YesYes   
Mus musculusNup509 of 9YesYes   
Mus musculusNup50l7 of 9NoYes   
Rattus norvegicusNup509 of 9YesYes   
Rattus norvegicusNup50-ps18 of 9NoYes   
Xenopus tropicalisnup505 of 9YesYes   
Danio rerionup509 of 10YesYes  
Caenorhabditis elegansnpp-167 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
long lived
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
Drosophila melanogasterNup50
is implicated inneurodegenerative disease
  • CEA
    Showing 1 - 1 of 1 rows
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    Alleles and Variants

    Genome location
    Assembly version
    R6
    Viewer Help
    8.1232M8.1234M8.1236M8.1238M8.1240M8.1242M8.1244M8.1246M8.1248M8.1250M
    Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
    Nup50KG09557
    • CG2158[KG09557]
    • CG2158KG09557
    allele with one associated variant
    insertion
    • 5 prime UTR variant
    Yes
    Nup50e02135
    • CG2158[e02135]
    • CG2158e02135
    allele with one associated variant
    insertion
    • coding sequence variant
    NT_033778.4:g.8123152A>Tvariant
    SNP
    • synonymous variant
    NT_033778.4:g.8123399G>Tvariant
    SNP
    • intron variant
    NT_033778.4:g.8123556T>Cvariant
    SNP
    • synonymous variant
    NT_033778.4:g.8124057C>Tvariant
    SNP
    • synonymous variant
    NT_033778.4:g.8124207A>Cvariant
    SNP
    • missense variant
    NT_033778.4:g.8124405A>Tvariant
    SNP
    • synonymous variant
    NT_033778.4:g.8124498T>Avariant
    SNP
    • synonymous variant
    NT_033778.4:g.8123398T>Cvariant
    SNP
    • intron variant
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    Transgenic Alleles

    Species
    (carrying the transgene)
    Allele symbol
    Transgenic construct
    Expressed components
    Knock-down targets
    Regulatory regions
    Has Disease Annotations
    Has Phenotype Annotations
    Drosophila melanogasterNup50GD9739
    • UASt
    Drosophila melanogasterNup50HMS01054
    • UAS
    Drosophila melanogasterNup50KK108150
    • UASt
    Yes
    Drosophila melanogasterNup50TKO.GS04125
    Drosophila melanogasterNup50U6.NIG.sgRNA
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    Models

    No data available

    Sequence Feature Viewer

    Genome location
    Assembly version
    R6
    Viewer Help
    8.1232M8.1234M8.1236M8.1238M8.1240M8.1242M8.1244M8.1246M8.1248M8.1250MNup50-RA (Nup50)coil-RD (coil)coil-RE (coil)

    Sequence Details

    Transcript: Mode:

    Expression

    Primary Sources
    Other Sources
    all annotationsall anatomical structuresalimentary part of gastrointestinal systemchemosensory systemcirculatory systemendocrine systemexocrine systemhemolymphoid systemhepatobiliary systemintegumental systemmechanosensory systemmusculoskeletal systemnervous systemrenal systemreproductive systemrespiratory systemsensory systemvestibulo-auditory systemvisual systemendodermectodermmesodermmesenchymeadipose tissueappendageentire extraembryonic componentimaginal precursorpharyngeal archotherall stagesembryo stagepost embryonic, pre-adultpost-juvenile adult stageall cellular componentsextracellular regionplasma membranesynapsecell junctioncell projectioncytoplasmic vesicleendosomevacuolegolgi apparatusendoplasmic reticulumcytosolmitochondrionnucleuschromosomecytoskeletonprotein-containing complexother locations
    Nup50 (Dme)
    Nup50 (Mmu)
    Nup50 (Rno)
    nup50 (Dre)
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    23 interactor genes based on 26 annotations
    Nup50 molecule type
    Interactor gene
    Interactor species
    Interactor molecule type
    Detection methods
    Source
    Reference
    protein
    Brca2Drosophila melanogaster
    protein
    • ion exchange chromatography
    PMID:25588834
    protein
    CcnDrosophila melanogaster
    protein
    • two hybrid
    PMID:14605208
    protein
    CG13407Drosophila melanogaster
    protein
    • two hybrid
    PMID:14605208
    protein
    CG15167Drosophila melanogaster
    protein
    • two hybrid
    PMID:14605208
    protein
    CG30447Drosophila melanogaster
    protein
    • experimental knowledge based
    PMID:22036573
    protein
    CG30447Drosophila melanogaster
    protein
    • two hybrid
    FB:FBrf0235788
    protein
    CG30447Drosophila melanogaster
    protein
    • two hybrid
    FB:FBrf0235788
    protein
    CG32354Drosophila melanogaster
    protein
    • two hybrid
    PMID:14605208
    protein
    cswDrosophila melanogaster
    protein
    • anti tag coimmunoprecipitation
    PMID:22028469
    protein
    dosDrosophila melanogaster
    protein
    • anti tag coimmunoprecipitation
    PMID:22028469
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    Genetic Interactions

    Nup50 role
    Nup50 genetic perturbation
    Interactor gene
    Interactor species
    Interactor role
    Interactor genetic perturbation
    Interaction type
    Phenotype or trait
    Source
    Reference
    suppressor gene
    domDrosophila melanogaster
    suppressed gene
    genetic suppression
      PMID:26555684
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