Gene

Nost

Species
Drosophila melanogaster
Symbol
Nost
Name
Nostrin
Synonyms
  • CG15364
  • CG33224
Biotype
protein coding gene
Automated Description
Enables lipid binding activity. Involved in epithelial cell differentiation; plasma membrane tubulation; and regulation of adherens junction organization. Located in endosome. Is expressed in several structures, including adult head; embryonic epipharynx; embryonic hypopharynx; germline cell; and gut section. Orthologous to human NOSTRIN (nitric oxide synthase trafficking).
FB Description
Nostrin (Nost) encodes a lipid binding protein involved in epithelial cell differentiation, plasma membrane tubulation and adherens junction organization.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23065
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensNOSTRIN3 of 9YesYes   
Mus musculusNostrin5 of 9YesYes   
Rattus norvegicusNostrin4 of 9YesYes   
Xenopus tropicalisnostrin2 of 9YesYes   
Danio rerionostrin5 of 10YesYes  
Caenorhabditis elegansC36E8.43 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
fertile
viable
Showing 1 - 2 of 2 rows
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

No mapped variant information available
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
Nostd07049
  • Nost[d07049]
allele
NostGG01078
  • Nost[GG01078]
allele
NostGG01569
  • Nost[GG01569]
allele
Nostf06397
  • Nost[f06397]
allele
NostG1266
  • Nost[G1266]
allele with one associated variant
insertion
  • intron variant
NostMI03851-TG4.0
  • Nost[MI03851-TG4.0]
allele with one associated variant
insertion
  • intron variant
Nostd08794
  • Nost[d08794]
allele with one associated variant
insertion
  • intron variant
Nostd01824
  • Nost[d01824]
allele with one associated variant
insertion
  • intron variant
Nostf00174
  • Nost[f00174]
allele with one associated variant
insertion
  • intron variant
Nostc06792
  • CG4040[c06792]
  • CG4040c06792
allele with one associated variant
insertion
  • intron variant
Yes
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Transgenic Alleles

Species
(carrying the transgene)
Allele symbol
Transgenic construct
Expressed components
Knock-down targets
Regulatory regions
Has Disease Annotations
Has Phenotype Annotations
Drosophila melanogasterNostGD11197
  • UASt
Drosophila melanogasterNostGD16372
  • UASt
Drosophila melanogasterNostGD8994
  • UASt
Drosophila melanogasterNostGL01145
  • UAS
Drosophila melanogasterNostHMJ23124
  • UAS
Drosophila melanogasterNostKK107795
  • UASt
Drosophila melanogasterNostKK109980
  • UASt
Drosophila melanogasterNostRNAi.UAS.cUa
  • UAS
Drosophila melanogasterNostUAS.EGFP
  • UAS
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Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
9.032M9.034M9.036M9.038M9.040M9.042M9.044M9.046M9.048M9.050M9.052M9.054MNost-RC (Nost)Nost-RD (Nost)Nost-RE (Nost)Nost-RF (Nost)Nost-RG (Nost)Nost-RH (Nost)CG10962-RB (CG10962)CG12662-RA (CG12662)CG12662-RB (CG12662)mir-31b-RA (mir-31b)Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

7 interactor genes based on 10 annotations
Nost molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
Cip4Drosophila melanogaster
protein
  • pull down
PMID:25413347
protein
Ect3Drosophila melanogaster
protein
  • experimental knowledge based
PMID:22036573
protein
Ect3Drosophila melanogaster
protein
  • anti tag coimmunoprecipitation
PMID:38944040
protein
Khc-73Drosophila melanogaster
protein
  • anti bait coimmunoprecipitation
PMID:25413347
protein
KyatDrosophila melanogaster
protein
  • two hybrid
PMID:14605208
protein
MetRS-mDrosophila melanogaster
protein
  • experimental knowledge based
PMID:22036573
protein
NostDrosophila melanogaster
protein
  • bimolecular fluorescence complementation
PMID:25413347
protein
Vps25Drosophila melanogaster
protein
  • two hybrid
PMID:14605208
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Genetic Interactions

Nost role
Nost genetic perturbation
Interactor gene
Interactor species
Interactor role
Interactor genetic perturbation
Interaction type
Phenotype or trait
Source
Reference
enhancer gene
Cip4Drosophila melanogaster
enhanced gene
genetic enhancement
    PMID:25413347
    enhancer gene
    Cip4Drosophila melanogaster
    enhanced gene
    genetic enhancement
      PMID:30733382
      Showing 1 - 2 of 2 rows
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