Version: 8.0.0
Date: Tue Jan 28 2025
RORB
Homo sapiensHGNC:10259
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

RORB

Species
Homo sapiens
Symbol
RORB
Name
RAR related orphan receptor B
Synonyms
  • bA133M9.1
  • EIG15
Biotype
protein coding gene
Automated Description
Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in several processes, including negative regulation of osteoblast differentiation; neural retina development; and regulation of DNA-templated transcription. Predicted to act upstream of or within retinal rod cell differentiation. Located in nucleoplasm. Implicated in idiopathic generalized epilepsy 15.
RGD Description
The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, and to help regulate the expression of some genes involved in circadian rhythm. [provided by RefSeq, Feb 2014]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45805
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Mus musculusRorb10 of 10YesYes☑☑☑☑☑☑☑☑☑☑  
Rattus norvegicusRorb10 of 10YesYes☑☑☑☑☑☑☑☑☑☑  
Xenopus laevisrorb.S1 of 1YesYes          ☑ 
Xenopus laevisrorb.2.S1 of 1YesYes          ☑ 
Xenopus laevisrorb.L1 of 1YesYes          ☑ 
Xenopus laevisrorb.2.L1 of 1YesYes          ☑ 
Danio reriororb10 of 10YesYes☑ ☑☑☑☑☑☑☑☑ ☑
Drosophila melanogasterHr39 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Caenorhabditis elegansnhr-238 of 9YesYes☑ ☑☑☐☑☑☑☑☑  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
RORA145777647 of 8☑ ☑☐☑☑☑☑☑ 
RORC250765487 of 8☑ ☑☐☑☑☑☑☑ 
NR1D2350350332 of 8☑ ☐☐☐☐☐☑☐ 
NR1D1451246322 of 8☑ ☐☐☐☐☐☑☐ 
PPARG546848282 of 8☑ ☐☐☐☐☐☑☐ 
VDR648944262 of 8☑ ☐☐☐☐☐☑☐ 
RARG748042282 of 8☑ ☐☐☐☐☐☑☐ 
PPARD846344282 of 8☑ ☐☐☐☐☐☑☐ 
THRB946244282 of 8☑ ☐☐☐☐☐☑☐ 
RARB1045343302 of 8☑ ☐☐☐☐☐☑☐ 
PPARA1145246272 of 8☑ ☐☐☐☐☐☑☐ 
RARA1246241282 of 8☑ ☐☐☐☐☐☑☐ 
NR1H41345044272 of 8☑ ☐☐☐☐☐☑☐ 
NR1I21449839252 of 8☑ ☐☐☐☐☐☑☐ 
NR1H31552937232 of 8☑ ☐☐☐☐☐☑☐ 
NR1H21645943252 of 8☑ ☐☐☐☐☐☑☐ 
THRA1740545262 of 8☑ ☐☐☐☐☐☑☐ 
NR1I31845234212 of 8☑ ☐☐☐☐☐☑☐ 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
Phenotype Term
Annotation details
References
Aggressive behavior
Atypical behavior
Autosomal dominant inheritance
Bilateral tonic-clonic seizure
Childhood onset
Cutaneous photosensitivity
Delayed speech and language development
Eyelid myoclonus
Generalized non-motor (absence) seizure
Global developmental delay
Showing 1 - 10 of 15 rows
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
No records match query. Try removing filters.
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    Alleles and Variants

    Genome location
    Assembly version
    GRCh38
    Viewer Help
    Data currently unavailable; sequence viewer under construction
    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
    NC_000009.12:g.74630275C>Tvariant
    SNP
    • splice region variant
    NC_000009.12:g.74630290G>Cvariant
    SNP
    • missense variant
    NC_000009.12:g.74630301A>Cvariant
    SNP
    • synonymous variant
    NC_000009.12:g.74630316C>Tvariant
    SNP
    • synonymous variant
    NC_000009.12:g.74630330G>Tvariant
    SNP
    • missense variant
    NC_000009.12:g.74642540T>Gvariant
    SNP
    • missense variant
    NC_000009.12:g.74642552G>Avariant
    SNP
    • missense variant
    NC_000009.12:g.74685606C>Tvariant
    SNP
    • synonymous variant
    NC_000009.12:g.74660653A>Gvariant
    SNP
    • missense variant
    NC_000009.12:g.74660704A>Gvariant
    SNP
    • missense variant
    Showing 1 - 10 of 343 rows
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    View detailed Alleles/Variants information
    Download all Alleles/Variants for all genes of the species

    Transgenic Alleles

    No data available

    Models

    No data available

    Sequence Feature Viewer

    Genome location
    Assembly version
    GRCh38
    Viewer Help
    Data currently unavailable; sequence viewer under construction

    Sequence Details

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    Expression

    Primary Sources
    None
    Other Sources
    Must provide at least one subject
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    38 interactor genes based on 44 annotations
    RORB molecule type
    Interactor gene
    Interactor species
    Interactor molecule type
    Detection methods
    Source
    Reference
    protein
    		ANKS1AHomo sapiens
    protein
    • two hybrid
    		PMID:32296183
    protein
    		CLOCKHomo sapiens
    protein
    • affinity chromatography technology
    		PMID:23555304
    protein
    		CLOCKHomo sapiens
    protein
    • two hybrid
    		PMID:23555304
    protein
    		ClockMus musculus
    protein
    • anti tag coimmunoprecipitation
    		PMID:23555304
    protein
    		ClockMus musculus
    protein
    • two hybrid
    		PMID:23555304
    protein
    		CRACR2AHomo sapiens
    protein
    • two hybrid
    		PMID:32296183
    protein
    		CSNK2BHomo sapiens
    protein
    • two hybrid
    		PMID:23555304
    protein
    		DELEC1Homo sapiens
    protein
    • two hybrid
    		PMID:23555304
    protein
    		GAS2L2Homo sapiens
    protein
    • two hybrid
    		PMID:32296183
    protein
    		H2AC20Homo sapiens
    protein
    • affinity chromatography technology
    		PMID:33961781
    Showing 1 - 10 of 44 rows
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    Genetic Interactions

    No data available