Gene

GAB4

Species
Homo sapiens
Symbol
GAB4
Name
GRB2 associated binding protein family member 4
Synonyms
  • GAB2-like
  • GRB2-associated binder 2-like protein
Biotype
protein coding gene
Automated Description
Predicted to enable transmembrane receptor protein tyrosine kinase adaptor activity. Predicted to be involved in signal transduction. Predicted to be active in cytoplasm.
RGD Description
Predicted to enable transmembrane receptor protein tyrosine kinase adaptor activity. Predicted to be involved in signal transduction. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45960
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Xenopus tropicalisgab23 of 9YesNo   
Danio reriogab23 of 10YesNo  
Drosophila melanogasterdos4 of 9YesYes   
Caenorhabditis eleganssoc-12 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
GAB2168162525 of 8  
GAB1276838265 of 8  
GAB3364740285 of 8  
PLEKHS1445237232 of 8  

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
No data available

Disease Associations

Cases where the expected disease association was NOT found
all annotationsall disease by infectious agentbacterial infectious diseasefungal infectious diseaseparasitic infectious diseaseviral infectious diseaseall disease of anatomical entitycardiovascular system diseasecentral nervous system diseaseendocrine system diseasegastrointestinal system diseasehematopoietic system diseaseimmune system diseaseintegumentary system diseasemusculoskeletal system diseaseperipheral nervous system diseasereproductive system diseaserespiratory system diseasesensory system diseasethoracic diseaseurinary system diseaseall disease of cellular proliferationbenign neoplasmcancerpre-malignant neoplasmall genetic diseasechromosomal diseasemonogenic diseasepolygenic diseaseall other diseasedisease of mental healthdisease of metabolismphysical disordersyndrome
GAB4 (Hsa)
gab2 (Xtr)
gab2 (Dre)
dos (Dme)
soc-1 (Cel)
Cell color indicative of annotation volume
No data available

Alleles and Variants

Genome location
Assembly version
GRCh38
Viewer Help
16.965M16.970M16.975M16.980M16.985M16.990M16.995M17.000M17.005M
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
NC_000022.11:g.16970045G>Avariant
SNP
  • missense variant
NC_000022.11:g.16970081T>Gvariant
SNP
  • missense variant
NC_000022.11:g.16992133C>Tvariant
SNP
  • missense variant
NC_000022.11:g.17008067G>Cvariant
SNP
  • missense variant
NC_000022.11:g.16966277C>Avariant
SNP
  • missense variant
NC_000022.11:g.16966223A>Cvariant
SNP
  • missense variant
NC_000022.11:g.16987985C>Tvariant
SNP
  • missense variant
NC_000022.11:g.16991929T>Cvariant
SNP
  • missense variant
NC_000022.11:g.16970072A>Cvariant
SNP
  • missense variant
NC_000022.11:g.16970699G>Cvariant
SNP
  • intron variant
Showing 1 - 10 of 45 rows
per page

Transgenic Alleles

No data available

Models

No data available

Sequence Details

Loading...

Expression

Primary Sources
None
Other Sources
all annotationsall anatomical structuresalimentary part of gastrointestinal systemchemosensory systemcirculatory systemendocrine systemexocrine systemhemolymphoid systemhepatobiliary systemintegumental systemmechanosensory systemmusculoskeletal systemnervous systemrenal systemreproductive systemrespiratory systemsensory systemvestibulo-auditory systemvisual systemendodermectodermmesodermmesenchymeadipose tissueappendageentire extraembryonic componentimaginal precursorpharyngeal archotherall stagesembryo stagepost embryonic, pre-adultpost-juvenile adult stageall cellular componentsextracellular regionplasma membranesynapsecell junctioncell projectioncytoplasmic vesicleendosomevacuolegolgi apparatusendoplasmic reticulumcytosolmitochondrionnucleuschromosomecytoskeletonprotein-containing complexother locations
GAB4 (Hsa)
dos (Dme)
soc-1 (Cel)
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

1 interactor gene based on 1 annotation
GAB4 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
DVL2Homo sapiens
protein
  • affinity chromatography technology
PMID:34299191
Showing 1 - 1 of 1 rows
per page

Genetic Interactions

No data available