Version: 8.0.0
Date: Tue Jan 28 2025
CYP1A1
Homo sapiensHGNC:2595
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

CYP1A1

Species
Homo sapiens
Symbol
CYP1A1
Name
cytochrome P450 family 1 subfamily A member 1
Synonyms
  • AHH
  • AHRR
Biotype
protein coding gene
Automated Description
Enables monooxygenase activity. Involved in several processes, including estrogen metabolic process; lipid hydroxylation; and retinol metabolic process. Acts upstream of or within cellular response to organic cyclic compound. Located in mitochondrion. Implicated in several diseases, including autoimmune disease (multiple); diabetes mellitus (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung disease (multiple). Biomarker of Keshan disease; dilated cardiomyopathy; endometriosis; renal cell carcinoma; and urinary bladder cancer.
RGD Description
This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24289
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Mus musculusCyp1a19 of 10YesYes☐☑☑☑☑☑☑☑☑☑  
Rattus norvegicusCyp1a19 of 10YesYes☐☑☑☑☑☑☑☑☑☑  
Xenopus laeviscyp1a1.S1 of 1YesYes          ☑ 
Xenopus laeviscyp1a1.L1 of 1YesYes          ☑ 
Xenopus tropicaliscyp1a15 of 9YesYes☑ ☐☐☑☑☐☑☑☐  
Danio reriocyp1a9 of 10YesYes☐ ☑☑☑☑☑☑☑☑ ☑
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
CYP1A2150885737 of 8☑ ☑☐☑☑☑☑☑ 
CYP1B1250757407 of 8☑ ☑☐☑☑☑☑☑ 
CYP2U1354351303 of 8☐ ☐☐☐☑☐☑☑ 
CYP17A1449851324 of 8☐ ☑☐☐☑☐☑☑ 
CYP2A13550553323 of 8☐ ☐☐☐☑☐☑☑ 
CYP2A7650552313 of 8☐ ☐☐☐☑☐☑☑ 
CYP2A6750452313 of 8☐ ☐☐☐☑☐☑☑ 
CYP2C19849451322 of 8☐ ☐☐☐☐☐☑☑ 
CYP2F1946553313 of 8☐ ☐☐☐☑☐☑☑ 
CYP2D71052149282 of 8☐ ☐☐☐☐☐☑☑ 
CYP2R11150249282 of 8☐ ☐☐☐☐☐☑☑ 
CYP21A21247049283 of 8☐ ☑☐☐☐☐☑☑ 
CYP2W11350245282 of 8☐ ☐☐☐☐☐☑☑ 
CYP2J2143 of 8☐ ☐☐☐☑☐☑☑ 
CYP2C9143 of 8☐ ☐☐☐☑☐☑☑ 
CYP2C8143 of 8☐ ☐☐☐☑☐☑☑ 
CYP2D6143 of 8☐ ☐☐☐☑☐☑☑ 
CYP2B6143 of 8☐ ☐☐☐☑☐☑☑ 
CYP2C18143 of 8☐ ☐☐☐☑☐☑☑ 
CYP2E1143 of 8☐ ☐☐☐☑☐☑☑ 
CYP2S1152 of 8☐ ☐☐☐☐☐☑☑ 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
Phenotype Term
Annotation details
References
Parkinsonism
Psoriasiform dermatitis
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
No records match query. Try removing filters.
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    Alleles and Variants

    Genome location
    Assembly version
    GRCh38
    Viewer Help
    Data currently unavailable; sequence viewer under construction
    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
    NC_000015.10:g.74720644T>Cvariant
    SNP
    • missense variant
    NC_000015.10:g.74720599G>Avariant
    SNP
    • missense variant
    NC_000015.10:g.74721022A>Gvariant
    SNP
    • missense variant
    NC_000015.10:g.74722820C>Tvariant
    SNP
    • missense variant
    NC_000015.10:g.74721217G>Tvariant
    SNP
    • missense variant
    NC_000015.10:g.74721692C>Tvariant
    SNP
    • missense variant
    NC_000015.10:g.74720586C>Gvariant
    SNP
    • missense variant
    NC_000015.10:g.74720646G>Tvariant
    SNP
    • missense variant
    NC_000015.10:g.74722964C>Tvariant
    SNP
    • missense variant
    NC_000015.10:g.74720638G>Tvariant
    SNP
    • missense variant
    Showing 1 - 10 of 39 rows
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    View detailed Alleles/Variants information
    Download all Alleles/Variants for all genes of the species

    Transgenic Alleles

    Species
    (carrying the transgene)
    Allele symbol
    Transgenic construct
    Expressed components
    Knock-down targets
    Regulatory regions
    Has Disease Annotations
    Has Phenotype Annotations
    Mus musculusCyp1a1tm2025.1(CYP1A1)Arte
    		Yes
    Mus musculusTg(CYP1A1,CYP1A2)1Dwn
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    Models

    No data available

    Sequence Feature Viewer

    Genome location
    Assembly version
    GRCh38
    Viewer Help
    Data currently unavailable; sequence viewer under construction

    Sequence Details

    Loading...

    Expression

    Primary Sources
    None
    Other Sources
    Must provide at least one subject
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    75 interactor genes based on 145 annotations
    CYP1A1 molecule type
    Interactor gene
    Interactor species
    Interactor molecule type
    Detection methods
    Source
    Reference
    protein
    		ACADVLHomo sapiens
    protein
    • affinity chromatography technology
    		PMID:26186194
    protein
    		ACTBL2Homo sapiens
    protein
    • affinity chromatography technology
    		PMID:28514442
    protein
    		ACTBL2Homo sapiens
    protein
    • affinity chromatography technology
    		PMID:33961781
    protein
    		ADD3Homo sapiens
    protein
    • affinity chromatography technology
    		PMID:26186194
    protein
    		ADD3Homo sapiens
    protein
    • affinity chromatography technology
    		PMID:28514442
    protein
    		AFDNHomo sapiens
    protein
    • affinity chromatography technology
    		PMID:26186194
    protein
    		AFDNHomo sapiens
    protein
    • affinity chromatography technology
    		PMID:28514442
    protein
    		AFDNHomo sapiens
    protein
    • affinity chromatography technology
    		PMID:33961781
    protein
    		ALDH6A1Homo sapiens
    protein
    • affinity chromatography technology
    		PMID:33961781
    protein
    		BRD4Homo sapiens
    protein
    • affinity chromatography technology
    		PMID:26186194
    Showing 1 - 10 of 145 rows
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    Genetic Interactions

    No data available