Version: 8.0.0
Date: Tue Jan 28 2025
ICAM1
Homo sapiensHGNC:5344
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

ICAM1

Species
Homo sapiens
Symbol
ICAM1
Name
intercellular adhesion molecule 1
Synonyms
  • BB2
  • CD54
Biotype
protein coding gene
Automated Description
Enables integrin binding activity. Involved in several processes, including T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; cellular response to amyloid-beta; and regulation of apoptotic process. Located in extracellular exosome. Implicated in several diseases, including autoimmune disease (multiple); biliary atresia; diabetic retinopathy; inflammatory bowel disease (multiple); and multiple myeloma. Biomarker of several diseases, including autoimmune disease (multiple); diabetes mellitus (multiple); hematologic cancer (multiple); liver disease (multiple); and lung disease (multiple).
RGD Description
This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13771
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Mus musculusIcam110 of 10YesYes☑☑☑☑☑☑☑☑☑☑  
Rattus norvegicusIcam110 of 10YesYes☑☑☑☑☑☑☑☑☑☑  
Danio rerioicam32 of 10YesYes☐ ☐☐☐☐☐☑☑☐ ☐
Danio reriosc:d02022 of 10YesYes☐ ☐☐☐☐☐☑☑☐ ☐
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
ICAM3154363476 of 8☑ ☑☐☑☑☑☑☐ 
ICAM5249264495 of 8☑ ☐☐☑☑☑☑☐ 
VCAM1362335212 of 8☐ ☐☐☐☐☑☑☐ 
ICAM2426848343 of 8☑ ☐☐☐☐☑☑☐ 
ICAM4528334234 of 8☑ ☑☐☐☐☑☑☐ 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
Phenotype Term
Annotation details
References
Cutaneous melanoma
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
No records match query. Try removing filters.
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    Alleles and Variants

    Genome location
    Assembly version
    GRCh38
    Viewer Help
    Data currently unavailable; sequence viewer under construction
    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
    NC_000019.10:g.10274844C>Tvariant
    SNP
    • synonymous variant
    NC_000019.10:g.10283591G>Avariant
    SNP
    • missense variant
    NC_000019.10:g.10284232C>Tvariant
    SNP
    • synonymous variant
    NC_000019.10:g.10283549C>Tvariant
    SNP
    • missense variant
    NC_000019.10:g.10284115C>Tvariant
    SNP
    • synonymous variant
    NC_000019.10:g.10284241C>Tvariant
    SNP
    • synonymous variant
    NC_000019.10:g.10284826G>Avariant
    SNP
    • synonymous variant
    NC_000019.10:g.10285120C>Tvariant
    SNP
    • missense variant
    NC_000019.10:g.10274827G>Avariant
    SNP
    • missense variant
    NC_000019.10:g.10274921A>Gvariant
    SNP
    • missense variant
    Showing 1 - 10 of 50 rows
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    View detailed Alleles/Variants information
    Download all Alleles/Variants for all genes of the species

    Transgenic Alleles

    Species
    (carrying the transgene)
    Allele symbol
    Transgenic construct
    Expressed components
    Knock-down targets
    Regulatory regions
    Has Disease Annotations
    Has Phenotype Annotations
    Mus musculusTg(ICAM1)4Grom
    		Yes
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    Models

    No data available

    Sequence Feature Viewer

    Genome location
    Assembly version
    GRCh38
    Viewer Help
    Data currently unavailable; sequence viewer under construction

    Sequence Details

    Transcript: Mode:

    Expression

    Primary Sources
    None
    Other Sources
    Must provide at least one subject
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    253 interactor genes based on 303 annotations
    ICAM1 molecule type
    Interactor gene
    Interactor species
    Interactor molecule type
    Detection methods
    Source
    Reference
    protein
    		A4GNTHomo sapiens
    protein
    • affinity chromatography technology
    		PMID:33961781
    protein
    		ACTBHomo sapiens
    protein
    • biochemical
    		PMID:31536960
    protein
    		ACTBHomo sapiens
    protein
    • affinity chromatography technology
    		PMID:23463506
    protein
    		ACTN1Homo sapiens
    protein
    • affinity chromatography technology
    		PMID:23463506
    protein
    		ACTN1Homo sapiens
    protein
    • affinity chromatography technology
    		PMID:23463506
    protein
    		ACTN1Homo sapiens
    protein
    • affinity chromatography technology
    		PMID:23463506
    protein
    		ACTN4Homo sapiens
    protein
    • affinity chromatography technology
    		PMID:23463506
    protein
    		ADAM7Homo sapiens
    protein
    • affinity chromatography technology
    		PMID:33961781
    protein
    		AHRHomo sapiens
    protein
    • affinity chromatography technology
    		PMID:33961781
    protein
    		AIFM1Homo sapiens
    protein
    • biochemical
    		PMID:31536960
    Showing 1 - 10 of 303 rows
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    Genetic Interactions

    No data available