Gene

PSMD9

Species
Homo sapiens
Symbol
PSMD9
Name
proteasome 26S subunit, non-ATPase 9
Synonyms
  • 26S proteasome non-ATPase regulatory subunit 9
  • 26S proteasome regulatory subunit p27
Biotype
protein coding gene
Automated Description
Predicted to enable bHLH transcription factor binding activity and transcription coactivator activity. Involved in proteasome regulatory particle assembly. Located in proteasome regulatory particle, base subcomplex.
RGD Description
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12651
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Mus musculusPsmd910 of 10YesYes  
Rattus norvegicusPsmd910 of 10YesYes  
Xenopus laevispsmd9.L1 of 1YesYes           
Xenopus laevispsmd9.S1 of 1YesYes           
Xenopus tropicalispsmd95 of 9YesYes   
Danio reriopsmd910 of 10YesYes  
Drosophila melanogasterCG95889 of 9YesYes   
Caenorhabditis eleganspsmd-99 of 9YesYes   
Saccharomyces cerevisiaeNAS28 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

No mapped variant information available
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
NC_000012.12:g.121921266T>Cvariant
SNP
  • intron variant
NC_000012.12:g.121899757G>Tvariant
SNP
  • missense variant
NC_000012.12:g.121894748A>Gvariant
SNP
  • missense variant
NC_000012.12:g.121894749T>Cvariant
SNP
  • missense variant
NC_000012.12:g.121915859C>Tvariant
SNP
  • missense variant
NC_000012.12:g.121888894C>Tvariant
SNP
  • missense variant
NC_000012.12:g.121915885G>Cvariant
SNP
  • missense variant
NC_000012.12:g.121915858G>Tvariant
SNP
  • splice acceptor variant
NC_000012.12:g.121903064A>Cvariant
SNP
  • missense variant
NC_000012.12:g.121888899G>Avariant
SNP
  • missense variant
Showing 1 - 10 of 19 rows
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Transgenic Alleles

Species
(carrying the transgene)
Allele symbol
Transgenic construct
Expressed components
Knock-down targets
Regulatory regions
Has Disease Annotations
Has Phenotype Annotations
Drosophila melanogasterHsap\PSMD9UAS.Tag:HA
  • UASt
Showing 1 - 1 of 1 rows
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Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
121.890M121.895M121.900M121.905M121.910M121.915M

Sequence Details

Transcript: Mode:

Expression

Primary Sources
None
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

173 interactor genes based on 266 annotations
PSMD9 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
ADAMTS1Homo sapiens
protein
  • two hybrid array
PMID:32814053
protein
ADAMTS1Homo sapiens
protein
  • two hybrid pooling approach
PMID:32814053
protein
ADAMTS1Homo sapiens
protein
  • validated two hybrid
PMID:32814053
protein
ADRM1Homo sapiens
protein
  • affinity chromatography technology
PMID:27114451
protein
AHCYL1Homo sapiens
protein
  • two hybrid
PMID:25416956
protein
AKT2Homo sapiens
protein
  • affinity chromatography technology
PMID:26186194
protein
AKT2Homo sapiens
protein
  • affinity chromatography technology
PMID:28514442
protein
AKT2Homo sapiens
protein
  • affinity chromatography technology
PMID:33961781
protein
AMOTL2Homo sapiens
protein
  • affinity chromatography technology
PMID:24255178
protein
ATG16L1Homo sapiens
protein
  • affinity chromatography technology
PMID:33961781
Showing 1 - 10 of 263 rows
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Genetic Interactions

PSMD9 role
PSMD9 genetic perturbation
Interactor gene
Interactor species
Interactor role
Interactor genetic perturbation
Interaction type
Phenotype or trait
Source
Reference
suppressed gene
CHUKHomo sapiens
suppressor gene
phenotypic suppression (sensu BioGRID)
PMID:24720748
enhanced gene
TNFHomo sapiens
enhancer gene
phenotypic enhancement (sensu BioGRID)
PMID:24720748
suppressor gene
TNFHomo sapiens
suppressed gene
phenotypic suppression (sensu BioGRID)
PMID:24720748
Showing 1 - 3 of 3 rows
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