Version: 8.0.0
Date: Tue Jan 28 2025
Psmc2
Mus musculusMGI:109555
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Psmc2

Species
Mus musculus
Symbol
Psmc2
Name
proteasome (prosome, macropain) 26S subunit, ATPase 2
Synonyms
  • MSS1
Biotype
protein coding gene
Automated Description
Predicted to enable TBP-class protein binding activity and proteasome-activating activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in P-body. Part of proteasome accessory complex. Is expressed in several structures, including autopod; frontal process; genitourinary system; and limb bud. Orthologous to human PSMC2 (proteasome 26S subunit, ATPase 2).
MGI Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23073
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensPSMC210 of 10YesYes☑☑☑☑☑☑☑☑☑☑  
Rattus norvegicusPsmc29 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Xenopus tropicalispsmc25 of 9YesYes☑ ☐☐☑☑☐☑☑☐  
Danio reriopsmc210 of 10YesYes☑ ☑☑☑☑☑☑☑☑ ☑
Drosophila melanogasterRpt19 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Caenorhabditis elegansrpt-19 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Saccharomyces cerevisiaeRPT19 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Psmc5140264483 of 9☑☐☐☐☐☐☑☑☐ 
Psmc1243959403 of 9☑☐☐☐☐☐☑☑☐ 
Psmc3344356383 of 9☑☐☐☐☐☐☑☑☐ 
Psmc6440262433 of 9☑☐☐☐☐☐☑☑☐ 
Psmc4542056393 of 9☑☐☐☐☐☐☑☑☐ 

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abnormal gait
decreased circulating alkaline phosphatase level
decreased circulating total protein level
increased circulating bilirubin level
preweaning lethality, complete penetrance
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Disease Associations

Cases where the expected disease association was NOT found
all annotationsall disease by infectious agentbacterial infectious diseasefungal infectious diseaseparasitic infectious diseaseviral infectious diseaseall disease of anatomical entitycardiovascular system diseasecentral nervous system diseaseendocrine system diseasegastrointestinal system diseasehematopoietic system diseaseimmune system diseaseintegumentary system diseasemusculoskeletal system diseaseperipheral nervous system diseasereproductive system diseaserespiratory system diseasesensory system diseasethoracic diseaseurinary system diseaseall disease of cellular proliferationbenign neoplasmcancerpre-malignant neoplasmall genetic diseasechromosomal diseasemonogenic diseasepolygenic diseaseall other diseasedisease of mental healthdisease of metabolismphysical disordersyndrome
Psmc2 (Mmu)
Cell color indicative of annotation volume
No data available

Alleles and Variants

No mapped variant information available
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
Psmc2tm1b(EUCOMM)Hmguallele
Yes
Psmc2em1Gpt
  • Psmc2em1Cd8130
allele
Psmc2tm1a(EUCOMM)Hmguallele
NC_000071.7:g.21991553C>Tvariant
SNP
  • intron variant
NC_000071.7:g.21990407G>Avariant
SNP
  • 5 prime UTR variant
NC_000071.7:g.21990528A>Gvariant
SNP
  • intron variant
NC_000071.7:g.21996338G>Avariant
SNP
  • intron variant
NC_000071.7:g.21996606T>Cvariant
SNP
  • intron variant
NC_000071.7:g.21996617C>Tvariant
SNP
  • intron variant
NC_000071.7:g.21997857C>Tvariant
SNP
  • intron variant
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View detailed Alleles/Variants information
Download all Alleles/Variants for all genes of the species

Transgenic Alleles

No data available

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
Psmc2tm1b(EUCOMM)Hmgu/Psmc2+ [background:] C57BL/6N-Psmc2tm1b(EUCOMM)Hmgu/Ieg
  • abnormal gait
  • decreased circulating alkaline phosphatase level
MGI
Psmc2tm1b(EUCOMM)Hmgu/Psmc2tm1b(EUCOMM)Hmgu [background:] C57BL/6N-Psmc2tm1b(EUCOMM)Hmgu/Ieg
  • preweaning lethality, complete penetrance
MGI
Showing 1 - 2 of 2 rows
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Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
21.992M21.994M21.996M21.998M22.000M22.002M22.004M22.006M22.008MENSMUST00000030769 (Psmc2)ENSMUST00000239497 (Psmc2)NM_001368661.1 (Psmc2)NM_011188.4 (Psmc2)

Sequence Details

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Expression

Primary Sources
Other Sources
all annotationsall anatomical structuresalimentary part of gastrointestinal systemchemosensory systemcirculatory systemendocrine systemexocrine systemhemolymphoid systemhepatobiliary systemintegumental systemmechanosensory systemmusculoskeletal systemnervous systemrenal systemreproductive systemrespiratory systemsensory systemvestibulo-auditory systemvisual systemendodermectodermmesodermmesenchymeadipose tissueappendageentire extraembryonic componentimaginal precursorpharyngeal archotherall stagesembryo stagepost embryonic, pre-adultpost-juvenile adult stageall cellular componentsextracellular regionplasma membranesynapsecell junctioncell projectioncytoplasmic vesicleendosomevacuolegolgi apparatusendoplasmic reticulumcytosolmitochondrionnucleuschromosomecytoskeletonprotein-containing complexother locations
Psmc2 (Mmu)
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

72 interactor genes based on 74 annotations
Psmc2 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
ActbMus musculus
protein
  • biochemical
PMID:32325033
protein
Adrm1Mus musculus
protein
  • biochemical
PMID:32325033
protein
Ago2Mus musculus
protein
  • biochemical
PMID:32325033
protein
Atxn1Mus musculus
protein
  • affinity chromatography technology
PMID:30457570
protein
CCNFHomo sapiens
protein
  • affinity chromatography technology
PMID:36114006
protein
Ddx6Mus musculus
protein
  • biochemical
PMID:32325033
protein
Dhx9Mus musculus
protein
  • biochemical
PMID:32325033
protein
Dync1i1Mus musculus
protein
  • biochemical
PMID:32325033
protein
EedMus musculus
protein
  • affinity chromatography technology
PMID:24457600
protein
Eif4eMus musculus
protein
  • biochemical
PMID:32325033
Showing 1 - 10 of 74 rows
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Genetic Interactions

No data available